The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 2, 2024
A
convenient
and
practical
method
has
been
developed
for
synthesizing
various
N-aryl
pyrazoles
from
vinyl
sulfoxonium
ylides
diazonium
salts.
When
using
1,3-disubstituted
ylides,
the
reaction
selectively
yields
1,3,5-trisubstituted
pyrazoles.
On
other
hand,
employing
2,3-disubstituted
results
in
formation
of
1,3,4-trisubstituted
The
proceeds
through
novel
aryl
diazene-derived
ylide.
Furthermore,
this
efficiently
produces
aniline
derivatives
a
one-pot
transformation.
takes
place
under
transition
metal-free,
mild
conditions
easily
accessible
starting
materials,
making
it
approach
generating
pharmaceutical
chemistry.
Organics,
Journal Year:
2024,
Volume and Issue:
5(4), P. 450 - 471
Published: Oct. 24, 2024
The
triazole
scaffold
is
a
crucial
component
of
heterocyclic
chemistry,
serving
as
basic
building
block
in
organic
synthesis,
materials
science,
and
medicinal
chemistry.
Triazole
five-membered
ring
composed
three
nitrogen
atoms
two
carbon
atoms,
it
exists
isomeric
forms:
1,2,3-triazole
1,2,4-triazole.
Compounds
featuring
the
are
important
heterocycles
known
for
their
diverse
biological
activities,
including
antimicrobial,
antiproliferative,
antimalarial,
anticonvulsant,
anti-inflammatory,
antineoplastic,
antiviral,
analgesic,
anticancer
properties.
As
result,
derivatives
have
attracted
significant
attention
from
researchers.
This
review
aims
to
provide
thorough
overview
published
studies
on
synthesis
derivatives,
highlighting
various
methods
obtaining
moiety.
These
include
classical
approaches
well
microwave
ultrasound-assisted
techniques.
Inorganica Chimica Acta,
Journal Year:
2024,
Volume and Issue:
572, P. 122283 - 122283
Published: July 26, 2024
An
outline
of
the
in
situ
construction
a
coordination
polymer
by
reacting
mononuclear
cobalt(II)
complex,
functionalised
with
an
amine
substituent,
acetone
is
given.
The
methodology
involved
4-amino-3,5-diisopropyl-1-pyrazole
(denoted
as
L1pzHNH2)
precursor,
putative
linker
molecule.
Reaction
ligand
anhydrous
chloride,
yielded
four-coordinated
chlorido
[CoCl2(L1pzHNH2)2].
When
complex
was
reacted
acetone,
polymer,
[CoCl2{L1pzHN=C(CH3)2}]n,
imine
bond,
obtained.
complexes
were
characterised
various
spectroscopic
techniques.
X-ray
crystallography
shows
[CoCl2(L1pzHNH2)2]·2(thf)
to
comprise
tetrahedrally
coordinated
centre
donors
being
two
and
pyrazolyl-N
atoms.
Similarly,
[CoCl2{L1pzHN=C(CH3)2}]n
features
Cl2N2
donor
set
defining
approximately
tetrahedral
geometry
imine-N
derived
from
pyrazolyl
ring
symmetry
related
exocyclic
atom
result
that
one-dimensional
helical
topology
formed.
uncoordinated
precursor
molecule,
L1pzHNH2,
formation
confirmed
1H
NMR
measured
(CD3)2CO
solution.
However,
for
CDCl3
solution,
70:30
equilibrium
between
established.
It
concluded
nucleophilicity
group
enhanced
binding
pyrazole
nitrogen
[CoCl2(L1pzHNH2)2]·2(thf),
thereby
favouring
irreversible
formation.
facile
solid-state
also
correlates
reduced
solubility
structure
organic
solvents.
Beilstein Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
20, P. 2024 - 2077
Published: Aug. 16, 2024
Pyrazoles
are
rarely
found
in
nature
but
traditionally
used
the
agrochemical
and
pharmaceutical
industries,
while
other
areas
of
use
also
actively
developing.
However,
they
have
numerous
applications.
The
search
for
new
efficient
syntheses
these
heterocycles
is
therefore
highly
relevant.
modular
concept
multicomponent
reactions
(MCR)
has
paved
a
broad
alley
to
heteroaromatics.
advantages
over
traditional
methods
broader
scope
increased
efficiency
reactions.
In
particular,
multistep
pyrazoles
considerably
been
extended
by
MCR.
Progress
made
cyclocondensation
1,3-dielectrophiles
that
generated
situ.
Limitations
regioselectivity
with
1,3-dicarbonyls
were
overcome
addition-cyclocondensation
α,β-unsaturated
ketones.
Embedding
1,3-dipolar
cycloadditions
into
one-pot
process
additionally
developed
concise
pyrazoles.
MCR
strategy
allows
concatenating
classical
condensation-based
methodology
modern
cross-coupling
radical
chemistry,
as
well
providing
versatile
synthetic
approaches
This
overview
summarizes
most
important
based
on
ring-forming
sequences
flashlight
fashion.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 2, 2024
A
convenient
and
practical
method
has
been
developed
for
synthesizing
various
N-aryl
pyrazoles
from
vinyl
sulfoxonium
ylides
diazonium
salts.
When
using
1,3-disubstituted
ylides,
the
reaction
selectively
yields
1,3,5-trisubstituted
pyrazoles.
On
other
hand,
employing
2,3-disubstituted
results
in
formation
of
1,3,4-trisubstituted
The
proceeds
through
novel
aryl
diazene-derived
ylide.
Furthermore,
this
efficiently
produces
aniline
derivatives
a
one-pot
transformation.
takes
place
under
transition
metal-free,
mild
conditions
easily
accessible
starting
materials,
making
it
approach
generating
pharmaceutical
chemistry.
