Polydimethylsiloxane Composites Characterization and Its Applications: A Review

Polymers, Journal Year: 2021, Volume and Issue: 13(23), P. 4258 - 4258

Published: Dec. 5, 2021

Polydimethylsiloxane (PDMS) is one of the most promising elastomers due its remarkable proprieties such as good thermal stability, biocompatibility, corrosion resistance, flexibility, low cost, ease use, chemically inertia, hyperplastic characteristics, and gas permeability. Thus, it can be used in areas microfluidic systems, biomedical devices, electronic components, membranes for filtering pervaporation, sensors, coatings. Although pure PDMS has mechanical properties, modulus elasticity strength, improved by mixing with other polymers adding particles or reinforcements. Fiber-reinforced proved to a alternative manufacturing flexible displays, batteries, wearable tactile energy harvesting systems. particulates are often separation liquids from wastewater means porosity followed hydrophobicity. Waxes beeswax paraffin have materials capable improving properties hydrophobic, corrosion-resistant, thermal, optical PDMS. Finally, when blended poly (vinyl chloride-co-vinyl acetate), becomes highly efficient membrane applications. However, best our knowledge there few works dedicated review comparison different composites. Hence, this will focused on composites, their respective applications, properties. Generally, combination elastomer fibers, particles, waxes, polymers, others discussed, aim producing that demonstrates wide applications material how tailored characteristics reached custom

Language: Английский

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Organ-On-A-Chip: A Survey of Technical Results and Problems

Frontiers in Bioengineering and Biotechnology, Journal Year: 2022, Volume and Issue: 10

Published: Feb. 10, 2022

Organ-on-a-chip (OoC), also known as micro physiological systems or "tissue chips" have attracted substantial interest in recent years due to their numerous applications, especially precision medicine, drug development and screening. devices can replicate key aspects of human physiology, providing insights into the studied organ function disease pathophysiology. Moreover, these accurately be used discovery for personalized medicine. These present useful substitutes traditional preclinical cell culture methods reduce use

Language: Английский

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3D-printed microrobots from design to translation

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Oct. 5, 2022

Microrobots have attracted the attention of scientists owing to their unique features accomplish tasks in hard-to-reach sites human body. can be precisely actuated and maneuvered individually or a swarm for cargo delivery, sampling, surgery, imaging applications. In addition, microrobots found applications environmental sector (e.g., water treatment). Besides, recent advancements three-dimensional (3D) printers enabled high-resolution fabrication with faster design-production turnaround time users limited micromanufacturing skills. Here, latest end 3D printed are reviewed (ranging from biomedical applications) along brief discussion over feasible actuation methods on- off-board), practical printing technologies microrobot fabrication. as future perspective, we discussed potential advantages integration smart materials, conceivable benefits implementation artificial intelligence (AI), well physical (PI). Moreover, order facilitate bench-to-bedside translation microrobots, current challenges impeding clinical elaborated, including entry obstacles immune system attacks) cumbersome standard test procedures ensure biocompatibility.

Language: Английский

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Progress of Microfluidic Hydrogel‐Based Scaffolds and Organ‐on‐Chips for the Cartilage Tissue Engineering

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(26)

Published: Jan. 12, 2023

Abstract Cartilage degeneration is among the fundamental reasons behind disability and pain across globe. Numerous approaches have been employed to treat cartilage diseases. Nevertheless, none shown acceptable outcomes in long run. In this regard, convergence of tissue engineering microfabrication principles can allow developing more advanced microfluidic technologies, thus offering attractive alternatives current treatments traditional constructs used applications. Herein, developments involving hydrogel‐based scaffolds, promising structures for regeneration, ranging from hydrogels with channels prepared by devices, that enable therapeutic delivery cells, drugs, growth factors, as well cartilage‐related organ‐on‐chips are reviewed. Thereafter, anatomy types damages, present treatment options briefly overviewed. Various introduced, advantages scaffolds over thoroughly discussed. Furthermore, available technologies fabricating chips presented. The preclinical clinical applications regeneration development time further explained. developments, recent key challenges, prospects should be considered so develop systems repair highlighted.

Language: Английский

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Multimaterial 3D printing of self-assembling smart thermo-responsive polymers into 4D printed objects: A review

Additive manufacturing, Journal Year: 2023, Volume and Issue: 71, P. 103598 - 103598

Published: May 9, 2023

The three-dimensional (3D) printing and its extension four-dimensional (4D) technique show great promise for advanced additive manufacturing of functional architected materials with engineered micro- nanoscale features. actual usage to produce 3D/4D structures is primarily dependent on the improvement printable polymeric inks. Thermoresponsive polymers (TRPs) broad application prospects in since they enable changing physicochemical properties system at a specific temperature. Continuing progress understanding TRP phenomena design new feedstocks their compatibility fabrication processes. Therefore, increasing overlap between fields fundamental TRPs application-based research efforts can be important emerging technology. In this review, we provide an overview TRPs, different classes 3D printing, ranging from biosensors via self-assembly variety biofabrication, biomedical, biotechnology, food applications. Basic knowledge imperative processes like gelation mechanisms bio-based adsorption surfaces adhesion, strategies using also provided. For diverse synthesis basic physical chemical features are described mechanism behavior highlighted. Fabrication methods have been discussed describing several detail.

Language: Английский

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Applications, advancements, and challenges of 3D bioprinting in organ transplantation

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(6), P. 1425 - 1448

Published: Jan. 1, 2024

To date, organ transplantation remains an effective method for treating end-stage diseases of various organs.

Language: Английский

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From Soft Lithography to 3D Printing: Current Status and Future of Microfluidic Device Fabrication

Polymers, Journal Year: 2025, Volume and Issue: 17(4), P. 455 - 455

Published: Feb. 9, 2025

The advent of 3D printing has revolutionized the fabrication microfluidic devices, offering a compelling alternative to traditional soft lithography techniques. This review explores potential printing, particularly photopolymerization techniques, fused deposition modeling, and material jetting, in advancing microfluidics. We analyze advantages terms cost efficiency, geometric complexity, versatility while addressing key challenges such as transparency biocompatibility, which have represented limiting factors for its widespread adoption. Recent developments technologies materials are highlighted, underscoring progress overcoming these barriers. Finally, we discuss future trends opportunities, including advancements resolution speed, development new printable materials, process standardization, emergence bioprinting organ-on-a-chip applications. Sustainability regulatory frameworks also considered critical aspects shaping 3D-printed By bridging gap between emerging this aims illuminate transformative device manufacturing.

Language: Английский

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3D Printing Technologies in Biosensors Production: Recent Developments

Chemosensors, Journal Year: 2022, Volume and Issue: 10(2), P. 65 - 65

Published: Feb. 7, 2022

Recent advances in 3D printing technologies and materials have enabled rapid development of innovative sensors for applications different aspects human life. Various been adopted to fabricate biosensors or some their components thanks the advantages these methodologies over traditional ones, such as end-user customization prototyping. In this review, works published last two years on 3D-printed are considered grouped basis applied fields application, highlighting main analytical parameters. first part, methods discussed, after which principal achievements promising obtained with reported. An overview recent developments current topic is provided, established by multidisciplinary field. Finally, future challenges improvement innovation utilized production discussed.

Language: Английский

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3D organ-on-a-chip: The convergence of microphysiological systems and organoids

Frontiers in Cell and Developmental Biology, Journal Year: 2022, Volume and Issue: 10

Published: Nov. 21, 2022

Medicine today faces the combined challenge of an increasing number untreatable diseases and fewer drugs reaching clinic. While pharmaceutical companies have increased in early development entering phase I clinical trials, actually successfully pass III launch into market. In fact, only 1 out every 9 will launch.

Language: Английский

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Organ-on-a-Chip Platforms for Drug Screening and Delivery in Tumor Cells: A Systematic Review

Cancers, Journal Year: 2022, Volume and Issue: 14(4), P. 935 - 935

Published: Feb. 13, 2022

The development of cancer models that rectify the simplicity monolayer or static cell cultures physiologic microenvironment and, at same time, replicate human system more accurately than animal has been a challenge in biomedical research. Organ-on-a-chip (OoC) devices are solution explored over last decade. combination microfluidics and culture allows design dynamic suitable for evaluation treatments’ efficacy effects, closer to response observed patients. This systematic review sums studies from decade, where OoC with were used drug screening assays. selected three databases analyzed following research guidelines reviews proposed by PRISMA. In studies, several types cells evaluated, majority treatments tested standard chemotherapeutic drugs. Some reported higher resistance on 2D cultures, which indicates better resemblance vivo conditions former. Several also included replication microvasculature different cultures. presence vasculature can influence positively negatively since it contributes greater diffusion oxygen nutrients. Co-cultures liver contributed systemic toxicity some drugs metabolites. Nevertheless, few patient

Language: Английский

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