Recent Advances in Biosensors for Diagnosis of Autoimmune Diseases

Sensors, Journal Year: 2024, Volume and Issue: 24(5), P. 1510 - 1510

Published: Feb. 26, 2024

Over the last decade, autoimmune diseases (ADs) have undergone a significant increase because of genetic and/or environmental factors; therefore, their simple and fast diagnosis is high importance. The conventional diagnostic techniques for ADs require tedious sample preparation, sophisticated instruments, dedicated laboratory, qualified personnel. For these reasons, biosensors could represent useful alternative to methods. Biosensors are considered be promising tools that can used in clinical analysis an early due sensitivity, simplicity, low cost, possible miniaturization (POCT), potential ability real-time analysis. In this review, recently developed detection disease biomarkers discussed. first part, we focus on main AD current methods detection. Then, discuss principles different types biosensors. Finally, overview characteristics based bioreceptors reported literature.

Language: Английский

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Sensing of Quercetin With Cobalt-Doped Manganese Nanosystems by Electrochemical Method

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: March 21, 2024

Background: The pressing need for precise, quick, and affordable detection of diverse biomolecules has led to notable developments in the realm biosensors. Quercetin, a biomolecule rich flavonoids predominantly found our diet, is sensed by electrochemical method. properties show remarkable improvement when Mn2O3 (MO) doped with cobalt (Co). Aim: This study aimed investigate sensing quercetin using Co-doped MO Materials methods: nanospheres were prepared hydrothermal crystal structure synthesized material was evaluated X-ray diffraction analysis. sample morphology assessed field emission scanning electron microscopy (FE-SEM) techniques. cyclic voltammetry technique used biomolecules. Results: appeared be spherical FE-SEM. Energy-dispersive spectroscopy showed only presence Co, Mn, O, which confirmed purity sample. modified electrode higher current 7.35 µA than bare glassy carbon 6.1 µA. Conclusion: exhibited enhanced conductivity, reactivity, performance. tailored approach will help optimization toward specific applications.

Language: Английский

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Biosensors used for orthopedics

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 377 - 398

Published: Jan. 1, 2025

Language: Английский

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Biomarkers for early diagnosis of rheumatoid arthritis

Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 120288 - 120288

Published: April 1, 2025

Language: Английский

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Highly wrinkled reduced graphene oxide nanocomposite coating for a multiplexed electrochemical biosensor

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162541 - 162541

Published: April 1, 2025

Language: Английский

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Molybdenum-Based Electrochemical Sensors for Breast Cancer Biomarker Detection: Advances and Challenges

Critical Reviews in Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 21

Published: April 21, 2025

Breast cancer, which is considered the most common type of cancer among women worldwide, estimated to reach 4.4 million cases in 2070. Early diagnosis has become very important prevent this expected increase. Various traditional methods, such as mammography, biopsy, enzyme immunoassay (EI), liquid immunohistochemistry (IGH), fluorescence situ hybridization (FISH) are used diagnose breast but fact that these methods expensive, have low sensitivity, and cause mutations tissues due X-rays led researchers discover faster, more cost-effective, easily detectable methods. In particular, increased levels new blood-based biomarkers circulation can be detected sensitively selectively by electrochemical facilitate early disease screening rapid diagnosis. This comprehensive review focuses on prevalence pathology clinical sensors molybdenum-based compounds for detection various recent years. Electrochemical analysis studies carried out field years compiled aptamer-based, nucleotide-based, immunosensors. The chemical properties molybdenum discussed, modifications electrode surface discussed under 4 headings: drop casting, electrodeposition, atomic layer deposition, electrophoretic deposition.

Language: Английский

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The Power of Antibodies: Advancing Biomarker-Based Disease Detection and Surveillance

Immunological Investigations, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 25

Published: April 21, 2025

Antibodies have long served as fundamental tools in disease diagnosis and surveillance. Their utility biomarkers has expanded beyond infectious diseases to encompass a wide range of health conditions. This review aims explore recent advancements antibody biomarker discovery their applications diagnosing monitoring diverse It also examines the role surveillance public epidemiological studies. A comprehensive analysis literature was conducted, focusing on studies that identify characterize disease-specific antibodies. Particular attention given relevance autoimmune diseases, infections, cancers, neurological disorders. The highlights clinical significance. discusses challenges antibody-based assessing prevalence, tracking immunity trends, supporting One Health strategies. Recent demonstrate significant potential improving early diagnosis, personalized treatment, population-level management. Antibody continues play pivotal guiding responses understanding dynamics.

Language: Английский

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Advancements of paper-based sensors for antibiotic-resistant bacterial species identification

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1)

Published: Dec. 13, 2024

Evolution of antimicrobial-resistant bacterial species is on a rise. This review aims to explore the diverse range paper-based platforms designed identify species. It highlights most important targets used for sensor development and examines applications nanosized particles in sensors. also discusses advantages, limitations, applicability various detection techniques sensing drug-resistant using platforms.

Language: Английский

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Metabolic Changes and Immunity Suppression Parameters as Biomarkers of Environmental Pollutants

Published: Jan. 1, 2024

Pollution occurring in our surroundings is one of the most consequential challenges to health modern world. Any foreign material that occupies space environment and produces a hazardous effect on human their activities, comes under category environmental pollutants. These pollutants are present through activities as well by nature which leads pollution. originate from soil, air, water, noise, radioactive material, thermal, agriculture, light, etc. having unfavorable effects immunity metabolic processes. Among all pollutants, air play vital role deficiency disorders. Air pollution causes range diseases, including nonalcoholic fatty liver disease, stroke, cardiovascular type-2 diabetes, chronic kidney peripheral artery skin neurological disorders, some types cancer, It also affects normal functioning regulation. metabolism-sensitive disorders usually result disruptions major molecular signaling pathways, can be caused hereditary lifestyle factors, exposure such endocrine-disrupting chemicals (EDCs). The metabolism acids, tryptophan, steroid hormone production, tyrosine triggered pollution, leading variety Cardiopulmonary diseases like CVD, COPD, Metsyn, characterized abdominal obesity, hypertriglyceridemia, low HDL, initiated directly increases levels cytokines IL-6, TNF-α indirectly activates NF-κB, AP-1 inflammatory pathways. Environmental have mutant responses evoke toxicity immune system. Immune triggered, mediated specific NLR- TLR-dependent mechanisms. interacting with receptor or producing secondary mediators DAMP PAMP alter activation TLR signaling, altered results modified profiles an increment proinflammatory responses. Various cells affected macrophages, neutrophils, dendritic give notification responses, lymphocytes enact them. Diseases autoimmune asthama, neural ailment, bronchitis, 2[SARS-CoV-2], connective tissue bowl cancer etc due suppression. In this chapter we aim summarize ambient system processes understanding how pathology could abrogated.

Language: Английский

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CUIDADOS INTEGRADOS PARA DOENÇAS AUTOIMUNES: REVISÃO INTEGRATIVA DE LITERATURA

Revista Foco, Journal Year: 2024, Volume and Issue: 17(11), P. e6553 - e6553

Published: Nov. 28, 2024

Os cuidados integrados para doenças autoimunes envolvem uma abordagem multidisciplinar que visa tratar o paciente de forma holística, tanto fisicamente quanto os aspectos emocionais e psicológicos. A detecção precoce é essencial melhorar as taxas sobrevivência a qualidade vida dos pacientes. No entanto, discussão dar-se-á pela procura eficácia em comparação com abordagens tradicionais no manejo autoimunes. Este trabalho busca revisar sintetizar principais evidências disponíveis na literatura sobre impacto das autoimunes, foco melhoria resultados clínicos pacientes, adotando como estudo revisão integrativa da literatura. As bases dados incumbidas esse processo foram Scielo, PubMed, Biblioteca Virtual Saúde (BVS), sendo consultadas utilizando descritores publicações últimos 5 anos, nos idiomas português inglês, estudos sistemática ensaios controlados possuam termo “Doença Autoimune" “Cuidados Integrados” seu título. Essa combinação terapias destaca importância um tratamento personalizado, por equipe contínua, ajustado às necessidades individuais do promovendo bem-estar geral paciente, minimizando sintomas prevenindo crises, garantindo mais equilibrada saudável. Portanto, diante crescente prevalência necessidade modelos assistenciais eficientes empáticos, vital.

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