Immersive Virtual Reality as Computer-Assisted Cognitive–Motor Dual-Task Training in Patients with Parkinson’s Disease

Medicina, Journal Year: 2025, Volume and Issue: 61(2), P. 248 - 248

Published: Feb. 1, 2025

Background and Objectives: The aim of this study was to determine the effect immersive virtual reality used as a short-term multifaceted activity with focus on motor cognitive function in patients Parkinson’s Disease. sub-objective focused quality life group patients. Materials Methods: Nineteen (64.2 ± 12.8 years) were included study. Inclusion criteria for study: adult Hoehn Yahr’s stage 1–3, cooperative, stable health status, independent mobile. IVR therapy performed twice week 20 min one month. Input output measurements taken within 14 days starting or ending therapy. 10 Meter Walk test examine assess both comfortable fast walking, Timed Up Go (TUG) + s dual task applied quickly highest possible level functional mobility. Berg Balance Scale (BBS) balance 14-item scale containing specific movement tasks. standardized Disease Questionnaire (PDQ-39) life. Data processed PAST program using nonparametric paired Wilcoxon test. significance set at α = 0.05. value r score evaluate size. Results: A significant reduction time walk 10MWT (p 0.006; 0.63) TUG < 0.001; 0.80) parameter found after Significant improvement BBS 0.016; 0.55). In PDQ-39 questionnaire, improvements domains mobility 0.027; 0.51) emotional well-being 0.011; 0.58). Conclusions: results indicate positive gait, which is also good terms reducing risk falls group. Therapy promoted

Language: Английский

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The Effect of Aerobic or Strength Training in Elderly with Cognitive Decline: The Fit4Alz Project

Journal of Sports Science and Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 172 - 186

Published: Feb. 24, 2025

This study aimed to examine the effects of aerobic and strength training methodologies, either combined with or without cognitive training, on mitigating decline. A total 154 subjects were recruited (72.8 ± 6.1 years, 69% females) divided into four groups: i) plus (STCT, n = 56); ii) (ST, 23); iii) (AT, 41); iv) (ATCT, 34). Subjects previously cognitively assessed showed decline (less than 26 points Montreal Cognitive Assessment, MoCA). For 12 weeks, all groups performed 3 times a week, for 60 minutes, program corresponding their attributed group. The MoCA test Senior Fitness applied at beginning end intervention. repeated-measures ANCOVA revealed significant time-by-group interactions physical performance measures, including 2-minute step-in-place (p 0.026), arm curl < 0.001), chair sit-and-reach back-scratch 8-foot up-and-go 6-minute walk tests 0.001). However, no improvements observed function (MoCA, p 0.242) lower body (chair stand, 0.411). AT group greater in upper compared STCT ST 0.001; d 0.698; 0.004; 0.598), while significantly improved flexibility ATCT 1.049). had greatest endurance 0.133; 0.350). It was demonstrated that overall elderly individuals. performance. Although these findings suggest both exercise, improve fitness, further research is needed determine its impact

Language: Английский

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Psychometric properties of outcome measures for freezing of gait in Parkinson’s disease: a systematic review and meta-analysis

Expert Review of Pharmacoeconomics & Outcomes Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

This systematic review and meta-analysis aimed to evaluate validated tools for assessing FOG in individuals with PD, focusing on their psychometric properties, linguistic adaptations, methodological quality. A search was conducted across MEDLINE, CINHAL, SCOPUS, Web of Science, following PRISMA-COSMIN guidelines. Studies validity, reliability, cross-cultural adaptation FOG-specific were included. Psychometric including internal consistency (Cronbach's alpha) test-retest reliability (Intraclass Correlation Coefficient, ICC), extracted. Methodological quality assessed using the COSMIN Risk Bias checklist, meta-analyses performed comparable studies. Six identified, FOG-Q NFOG-Q emerging as most robust. Meta-analysis revealed high (FOG-Q: α = 0.90; NFOG-Q: 0.87-0.89) (FOG-Q ICC 0.87), but heterogeneity (I2 71.1-86.4%) substantial. Emerging tools, CFOG-Q, Ziegler test, DYPAGS, addressed cognitive dual-tasking dimensions lacked sufficient validation. remain widely used assessment. However, recent findings suggest that may present limitations detecting small clinical changes, highlighting need cautious interpretation trials.Broader cultural adaptations are still requiredand hold promise addressing multidimensional aspects FOG. Future research should focus integrating subjective objective measures comprehensive globally applicable assessments. PROSPERO (CRD42020173873).

Language: Английский

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Computer Games Based Dual-Task Testing and Training of Gait Visuomotor and Executive Cognitive Functions in Parkinson's Disease: A feasibility study

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Introduction Parkinson's Disease (PD) often leads to worsened gait and cognitive performance under dual-task conditions, making it essential explore interventions that target both motor functions. A treadmill-based motor-cognitive system, enhanced with computer games, may provide a cost-effective solution improve spatiotemporal parameters executive functions in individuals PD. Objective The feasibility of design for evaluation games-based treadmill (CDT) intervention PD was assessed. Adherence acceptance the analysed. Method Five community-dwelling participants (age 52-76 years) were recruited. involved (DT) training, where engaged commercial games while walking on sessions 45 minutes held twice week over period 8 weeks. Inclusion criteria included successful completion 6-minute test 20-meter speed assessment. Cognitive function assessed using Montreal Assessment (MoCA). Spatiotemporal recorded from pre- post-intervention. Executive outcomes through computer-based tasks. Semi-structured qualitative interviews conducted after Results All adhered minimal absences. From post-intervention, improvements observed physical performance. Specifically, reductions walk time (median score 12.3s 10.6s), increased distance 418m 497m), parameters, including stride length step duration. function, as by MoCA, also improved 25 27). Notably, identified six key themes: motivation, perceived improvements, challenges faced during intervention, engagement method, aspects dual-tasking, future intentions. These themes show participants' value they encountered, their interest continuing similar therapy. Conclusion CDT feasible well-accepted. It resulted significant mobility Participants found valuable enhancing abilities

Language: Английский

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Impact of Physical Activity on Cellular Metabolism Across Both Neurodegenerative and General Neurological Conditions: A Narrative Review

Cells, Journal Year: 2024, Volume and Issue: 13(23), P. 1940 - 1940

Published: Nov. 22, 2024

Background: Regular physical activity plays a crucial role in modulating cellular metabolism and mitigating the progression of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Multiple Sclerosis. Objective: The objective this review is to evaluate molecular mechanisms by which exercise influences metabolism, with focus on its potential therapeutic intervention for neurological disorders. Methods: A comprehensive literature was conducted using peer-reviewed scientific articles, period between 2015 2024, analyze effects mitochondrial function, oxidative stress, metabolic health. Results: findings indicate that promotes biogenesis, enhances phosphorylation, reduces reactive oxygen species, contributing improved energy production resilience. These adaptations are associated delayed disease reduced symptoms patients conditions. Additionally, integrating nutritional strategies may further enhance outcomes addressing disturbances comprehensively. Conclusions: This concludes personalized protocols should be developed optimize benefits diseases, while future research biomarker development individualized treatment approaches. highlight importance non-pharmacological interventions managing diseases.

Language: Английский

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