Cumin (Cuminum cyminum L.) seeds accelerates wound healing in rats: Possible molecular mechanisms

Skin Research and Technology, Journal Year: 2024, Volume and Issue: 30(5)

Published: May 1, 2024

Abstract Wound healing is a complex, intricate, and dynamic process that requires effective therapeutic management. The current study evaluates the wound potentials of methanolic extract Cuminum cyminum L. seeds (CCS) in rats. Sprague Dawley (24) rats were distributed into four cages, wounds produced on back neck, received two daily topical treatments for 14 days: A, normal saline; B, wounded treated with intrasite gel; C D, 0.2 mL 250 500 mg/kg CCS, respectively. After that, area closure percentage evaluated, tissues dissected histopathological, immunohistochemical, biochemical examinations. Acute toxicity trials CCS showed absence any physiological changes or mortality application caused significant reduction size statistically elevated contraction than those vehicle treatment up‐regulation collagen fiber, fibroblasts, fewer inflammatory cells (inflammation) granulation tissues. TGF‐β1 (angiogenetic factor) was significantly more expressed CCS‐treated comparison to saline‐treated rats; therefore, fibroblasts transformed myofibroblasts (angiogenesis). remarkable antioxidant (higher SOD CAT enzymes) decreased MDA (lipid peroxidation) levels their tissue homogenates. Hydroxyproline amino acid (collagen) up‐regulated by treatment, which commonly related faster area. outcomes suggest as viable new source pharmaceuticals treatment.

Language: Английский

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Climatic variables are more effective on the spatial distribution of oak forests than land use change across their historical range

Environmental Monitoring and Assessment, Journal Year: 2024, Volume and Issue: 196(3)

Published: Feb. 21, 2024

Language: Английский

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Prediction of Historical, Current, and Future Configuration of Tibetan Medicinal Herb Gymnadenia orchidis Based on the Optimized MaxEnt in the Qinghai–Tibet Plateau

Plants, Journal Year: 2024, Volume and Issue: 13(5), P. 645 - 645

Published: Feb. 26, 2024

Climate change plays a pivotal role in shaping the shifting patterns of plant distribution, and gaining insights into how medicinal plants plateau region adapt to climate will be instrumental safeguarding rich biodiversity highlands. Gymnosia orchidis Lindl. (G. orchidis) is valuable Tibetan resource with significant medicinal, ecological, economic value. However, growth G. severely constrained by stringent natural conditions, leading drastic decline its resources. Therefore, it crucial study suitable habitat areas facilitate future artificial cultivation maintain ecological balance. In this study, we investigated zones based on 79 occurrence points Qinghai–Tibet Plateau (QTP) 23 major environmental variables, including climate, topography, soil type. We employed Maximum Entropy model (MaxEnt) simulate predict spatial distribution configuration changes during different time periods, last interglacial (LIG), Last Glacial (LGM), Mid-Holocene (MH), present, scenarios (2041–2060 2061–2080) under three (SSP126, SSP370, SSP585). Our results indicated that annual precipitation (Bio12, 613–2466 mm) mean temperature coldest quarter (Bio11, −5.8–8.5 °C) were primary factors influencing orchidis, cumulative contribution 78.5%. The driest season had most overall impact. Under current covered approximately 63.72 × 104/km2, encompassing Yunnan, Gansu, Sichuan, parts Xizang provinces, highest suitability observed Hengduan, Yunlin, Himalayan mountain regions. past, area experienced Mid-Holocene, variations total centroid migration direction. scenarios, projected expand significantly SSP370 (30.33–46.19%), followed SSP585 (1.41–22.3%), while contraction expected SSP126. Moreover, centroids exhibited multidirectional movement, extensive displacement (100.38 km2). This provides theoretical foundation for conservation endangered QTP.

Language: Английский

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Assessing spatial thermal comfort and adaptation measures for the Antalya basin under climate change scenarios

Climatic Change, Journal Year: 2024, Volume and Issue: 177(8)

Published: July 17, 2024

Abstract The concrete damages of climate change are intensifying, and adaptation efforts actors around the world increasing, especially in coastal regions. Recommending measures for specific regions sectors determining long-term strategies mitigating global is essential reducing vulnerability to change. This research aims estimate changes climatic parameters thermal comfort zones determine targets offer suggestions affected by possible changes. that will occur until 2100 Antalya basin, which located southernmost part Türkiye a significant hub agricultural production tourism, were monitored spatially using Discomfort Index (DI) Effective Temperature taking wind velocity (ET v ). Shared Socioeconomic Pathways (SSP): SSP 245 585 predict quite cool areas prevailing area, according ET , shrink 24% 46%, respectively, cold areas, DI, 45% 56%, respectively. By 2100, 5% 245, 25%, 585, turn into hot move away from level. fact critical with high vitality terms tourism shows need prioritize policies. These discoveries discussed context issues such as water scarcity food security, contributing policy-making effective management suggesting measures.

Language: Английский

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A CMIP6 Multi-Model Analysis of the Impact of Climate Change on Severe Meteorological Droughts through Multiple Drought Indices—Case Study of Iran’s Metropolises

Water, Journal Year: 2024, Volume and Issue: 16(5), P. 711 - 711

Published: Feb. 28, 2024

This study extensively explores the impact of climate change on meteorological droughts within metropolises in Iran. Focused Tehran, Mashhad, Isfahan, Karaj, Shiraz, and Tabriz, this research employed CMIP6 models under varying scenarios (SSPs) to forecast severe spanning period from 2025 2100. The investigation utilized a diverse set drought indices (SPI, DI, PN, CZI, MCZI, RAI, ZSI) assess severity each city. is crucial as it addresses pressing concerns rapidly decreasing water levels Iran’s dams, serious declines underground aquifers, compounding issues land subsidence soil erosion due excessive groundwater withdrawal face droughts. culminated generation box plots heatmaps based results. These visual representations elucidated distribution values different provided depiction probability occurrences until end century for resulting findings serve invaluable tools, furnishing policymakers with informed insights proactively manage fortify metropolitan resilience against evolving challenges posed by changing climate.

Language: Английский

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Predicting the spatial distribution of three Ephedra species under climate change using the MaxEnt model

Heliyon, Journal Year: 2024, Volume and Issue: 10(12), P. e32696 - e32696

Published: June 1, 2024

In the context of global warming, habitats

Language: Английский

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Predicting the Spatial Distribution of Hyalomma ssp., Vector Ticks of Crimean–Congo Haemorrhagic Fever in Iraq

Sustainability, Journal Year: 2023, Volume and Issue: 15(18), P. 13669 - 13669

Published: Sept. 13, 2023

Crimean–Congo hemorrhagic fever (CCHF) typically spreads through ticks and is categorized as a viral fever. CCHF fatal endemic disease in Iraq, it has been reported sporadically since its first report 1979. Recent outbreaks during 2021–2023 their consequences captured the interest of this study. tick-borne that represents major challenge to public health, social, economic sectors. The geographical distribution closely linked with Hyalomma vector tick distribution. Therefore, predicting mapping spatial relation relevant environmental factors provides invaluable information for establishing an early warning system based on which preventive measures can be taken minimize spread and, hence, CCHF. To achieve this, study incorporates geospatial techniques maximum entropy modeling (Maxent) assess habitat suitability identify key drivers contributing Iraq. Utilizing area under ROC curve (AUC) performance metric, model evaluation yielded successful results AUC attained average score 0.885 regularization multiplier (β) set at 1. ticks’ suitable within covers fraction total land, approximately 51% (225,665 km2) entire 441,724 km2 region. Among these areas, 41.57% (183,631 were classified lowly suitable, 8.61% (38,039 moderately 0.9% (3994 highly suitable. Several have significantly influenced These include land cover (accounting 50.8%), elevation (contributing 30.4%), NDVI (5.7%), temperature seasonality (4.7%), precipitation (3.3%), sheep density (2.3%), goat (2.2%), mean diurnal range (0.5%). findings could significant implications strategic taking beforehand control haemorrhagic Iraq similar ecoregions Middle East. As primary precaution, recommends focusing areas southern part management actions.

Language: Английский

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Geographical Distribution, Habitat Suitability and Epidemiological Factors of Tef Head Smudge Disease in the Western Amhara Region, Ethiopia

Journal of Phytopathology, Journal Year: 2025, Volume and Issue: 173(1)

Published: Jan. 1, 2025

ABSTRACT Tef head smudge ( Curvularia miyakei ) is an economically important plant disease in the warm‐humid regions of Western Amhara Region, Ethiopia. Therefore, this study aimed to assess geographical distribution, habitat suitability and epidemiological factors influencing incidence severity disease. The result depicted that widely distributed across region at varying levels severity. Sowing date, soil type, altitude growth stage are key contributing variability Moreover, isothermally, temperature seasonality minimum coldest month bioclimatic variables significantly influenced dynamics. Our also predicted current using MaxEnt (maximum entropy) species distribution model. model was good predicting with AUC (area under Receiver Operating Curve) 0.85. According model, 31.18%, 44.46% 14.33% areas have highly suitable, moderately suitable low respectively, whereas 10.03% unsuitable This underscores a significant portion Region (75.64%) similar agro‐ecologies risk outbreaks. it implement targeted breeding programs management strategies ensure food security where tef primary source prevalent.

Language: Английский

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Evaluating the Impact of Climate Change on the Asia Habitat Suitability of Troides helena Using the MaxEnt Model

Insects, Journal Year: 2025, Volume and Issue: 16(1), P. 79 - 79

Published: Jan. 14, 2025

Butterflies are highly sensitive to climate change, and Troides helena, as an endangered butterfly species, is also affected by these changes. To enhance the conservation of T. helena effectively plan its protected areas, it crucial understand potential impacts change on distribution. This study utilized a MaxEnt model in combination with ArcGIS technology predict global suitable habitats under current future conditions, using species’ distribution data relevant environmental variables. The results indicated that provided good prediction accuracy for helena. Under scenario, species primarily distributed tropical regions, high suitability areas concentrated rainforest climates. In scenarios, habitat medium categories generally show expansion trend, which increases over time. Especially SSP5-8.5 2090s, area projected increase 42.85%. analysis key factors revealed precipitation wettest quarter (Bio16) was most significant factor affecting has demands temperature can adapt warming. valuable identifying optimal provides reference efforts.

Language: Английский

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Prediction of the shift of the distribution of Pinus brutia Ten. Under future climate model

New Forests, Journal Year: 2025, Volume and Issue: 56(2)

Published: Jan. 24, 2025

Language: Английский

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