Retinal Inflammation and Reactive Müller Cells: Neurotrophins’ Release and Neuroprotective Strategies DOI Creative Commons
Bijorn Omar Balzamino, Andrea Cacciamani, Lucia Dinice

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(12), P. 1030 - 1030

Published: Dec. 9, 2024

Millions of people worldwide suffer from retinal disorders. Retinal diseases require prompt attention to restore function or reduce progressive impairments. Genetics, epigenetics, life-styling/quality and external environmental factors may contribute developing diseases. In the physiological retina, some glial cell types sustain neuron activities by guaranteeing ion homeostasis allowing effective interaction in synaptic transmission. Upon insults, cells interact with neuronal other non-neuronal cells, at least part counteracting biomolecular changes that trigger complications vision loss. Several epigenetic oxidative stress mechanisms are quickly activated release concert growth, fibrogenic angiogenic can influence overall microenvironment cell-to-cell response. Reactive Müller participate secreting neurotrophic/growth/angiogenic factors, cytokines/chemokines, cytotoxic/stress molecules neurogenic inflammation peptides. Any attempt maintain/restore condition be interrupted perpetuating vascular dysfunction neurodegeneration. Herein, we critically revise current knowledge on cell-to-mediator interplay between astrocytes microglia, respect pro-con modulators neuroprotective/detrimental activities, as observed using experimental models analyzing ocular fluids, altogether contributing a new point view field research precision medicine.

Language: Английский

Biological significance and pathophysiological role of Matrix Metalloproteinases in the Central Nervous System DOI
Krishnendu Ganguly, Krishnendu Adhikary, Arup Acharjee

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 135967 - 135967

Published: Sept. 1, 2024

Language: Английский

Citations

6
Vitamin A and its influence on tumour extracellular matrix DOI Creative Commons
Guoqing Xie,

Shun Cao,

Guangchun Wang

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 7, 2025

Vitamin A is a crucial nutrient renowned for its role in visual health and cellular regulation. Its derivatives influence cell differentiation, proliferation, tissue homeostasis, making them significant cancer research due to their effects on both normal tumour cells. This review explores the intricate relationship between vitamin metabolism extracellular matrix (ECM) cancer. The ECM profoundly affects behaviour, including invasion, metastasis. Alterations can facilitate progression, have shown potential modulating these changes. Through transcriptional regulation, impacts components metalloproteinases, influencing dynamics. highlights of as adjunctive agents therapy. Despite promising laboratory findings, clinical application remains limited challenges translating into therapeutic outcomes. Future should focus modulation retinol within tumours development targeted therapies enhance treatment efficacy improve patient prognosis.

Language: Английский

Citations

0
Testing the inhibitory effects of different algal extracts on fish intestinal metalloproteases using in vitro assays DOI
Francisca P. Martínez-Antequera, Neda Gilannejad, Simon Menanteau‐Ledouble

et al.

Journal of Applied Phycology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 11, 2025

Language: Английский

Citations

0
INTEGRATING CANCER GENETICS WITH METASTATIC BIOMARKER DYNAMICS: MMP-2, AND MMP-9 IN BREAST CANCER PROGRESSION AND DISEASE MANAGEMENT DOI Creative Commons

M. Rizwan Sardar,

Moawia M. Mukhtar,

Ayesha Muddasser

et al.

Published: Jan. 17, 2025

Background: Breast cancer is one of the leading causes cancer-related morbidity and mortality globally, with its metastatic nature contributing significantly to poor clinical outcomes. Identifying reliable plasma biomarkers associated angiogenesis metastasis crucial for improving early diagnosis, disease progression monitoring, therapeutic interventions. Matrix metalloproteinases, particularly MMP-2 MMP-9, play pivotal roles in tumor invasion metastasis, making them potential candidates biomarker development. Objective: This study aimed determine expression levels MMP-9 breast patients assess their association clinicopathological variables evaluate as advanced assessment. Methods: A total 116 24 healthy controls were included this cross-sectional study. Peripheral blood samples (5 ml) collected EDTA tubes, followed by RNA extraction using TRIzol reagent. High-quality was reverse transcribed into cDNA, gene quantified RT-qPCR. Expression analyzed relation grade, molecular subtypes, stages. Statistical analyses performed GraphPad Prism 9, significance set at p < 0.05. Results: elevated compared controls. highest grade 3 tumors (p = 0.0104) showed an increasing trend TNM stages 0.0345). III IV 0.0373) aggressive including HER2-enriched triple-negative cancer. Observed correlated strongly variables, subtype. Conclusion: The increased highlights role angiogenesis. These show use severity assessment targeting, offering prospects management.

Language: Английский

Citations

0
From Bench to Bedside: Transforming Cancer Therapy with Protease Inhibitors DOI Open Access
Alireza Shoari

Targets, Journal Year: 2025, Volume and Issue: 3(1), P. 8 - 8

Published: March 3, 2025

Proteases play a pivotal role in cancer progression, facilitating processes such as extracellular matrix degradation, angiogenesis, and metastasis. Consequently, protease inhibitors have emerged promising therapeutic agents oncology. This review provides comprehensive overview of the mechanisms by which modulate biology, categorizing their target classes, including metalloproteinases, cysteine proteases, serine proteases. We discuss potential both synthetic natural inhibitors, highlighting applications preclinical clinical settings. Furthermore, challenges specificity, toxicity, resistance are addressed, alongside strategies to overcome these limitations through innovative drug designs combination therapies. The future treatment lies precision medicine, leveraging proteomic profiling tailor therapies individual tumors. underscores importance ongoing research development novel approaches harness effectively for management.

Language: Английский

Citations

0
Matrix metalloproteinase-driven epithelial-mesenchymal transition: implications in health and disease DOI Creative Commons
Ghazaleh Khalili‐Tanha, Evette S. Radisky, Derek C. Radisky

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 11, 2025

Epithelial-mesenchymal transition (EMT) is a process in which epithelial cells, defined by apical-basal polarity and tight intercellular junctions, acquire migratory invasive properties characteristic of mesenchymal cells. Under normal conditions, EMT directs essential morphogenetic events embryogenesis supports tissue repair. When dysregulated, contributes to pathological processes such as organ fibrosis, chronic inflammation, cancer progression metastasis. Matrix metalloproteinases (MMPs)-a family zinc-dependent proteases that degrade structural components the extracellular matrix-sit at nexus this dismantling basement membranes, activating pro-EMT signaling pathways, cleaving adhesion molecules. normally regulated, MMPs promote balanced ECM turnover support cyclical remodeling necessary for proper development, wound healing, homeostasis. abnormally drive excessive turnover, thereby promoting EMT-related pathologies, including tumor fibrotic disease. This review provides an integrated overview molecular mechanisms both initiate sustain under physiological disease conditions. It discusses how can potentiate through TGF-β Wnt/β-catenin signaling, disrupt cell-cell junction proteins, action hypoxia-inducible factors microenvironment. these pathologic remodel tissues during fuel cell invasion, metastasis, resistance therapy. Finally, explores emerging therapeutic strategies selectively target EMT, ranging from CRISPR/Cas-mediated interventions engineered inhibitors (TIMPs), demonstrates approaches may suppress without compromising its indispensable roles biology.

Language: Английский

Citations

0
Targeting Invasion: The Role of MMP-2 and MMP-9 Inhibition in Colorectal Cancer Therapy DOI Creative Commons
Alireza Shoari,

Arghavan Ashja Ardalan,

Alexandra M. Dimesa

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 15(1), P. 35 - 35

Published: Dec. 30, 2024

Colorectal cancer (CRC) remains one of the most prevalent and lethal cancers worldwide, prompting ongoing research into innovative therapeutic strategies. This review aims to systematically evaluate role gelatinases, specifically MMP-2 MMP-9, as targets in CRC, providing a critical analysis their potential improve patient outcomes. Gelatinases, play roles processes tumor growth, invasion, metastasis. Their expression activity are significantly elevated correlating with poor prognosis lower survival rates. provides comprehensive overview pathophysiological gelatinases highlighting contribution microenvironment modulation, angiogenesis, metastatic cascade. We also critically recent advancements development gelatinase inhibitors, including small molecule natural compounds, novel approaches like gene silencing techniques. Challenges such nonspecificity, adverse side effects, resistance mechanisms discussed. explore inhibition combination therapies, particularly conventional chemotherapy emerging targeted treatments, enhance efficacy overcome resistance. The novelty this lies its integration findings on diverse strategies insights clinical relevance, offering roadmap for future research. By addressing limitations current proposing strategies, underscores inhibitors CRC prevention therapy, inspiring further exploration promising area oncological treatment.

Language: Английский

Citations

2
Shaping the Landscape of Lung Cancer: The Role and Therapeutic Potential of Matrix Metalloproteinases DOI Creative Commons

Arghavan Ashja Ardalan,

Ghazaleh Khalili‐Tanha, Alireza Shoari

et al.

International Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 4(4), P. 661 - 679

Published: Nov. 22, 2024

Lung cancer is a leading cause of cancer-related mortality worldwide, characterized by its aggressive nature and poor prognosis. Matrix metalloproteinases (MMPs), family zinc-dependent endopeptidases, play pivotal role in the progression lung cancer. They contribute to tumor invasion, metastasis, angiogenesis, modulation microenvironment degrading extracellular matrix components regulating various cellular signaling pathways. Elevated levels specific MMPs, such as MMP-2, MMP-9, MMP-14, have been associated with advanced disease stages reduced survival rates. As such, MMPs emerged valuable biomarkers for diagnosis, prognosis, prediction treatment responses This review aims provide comprehensive overview current understanding cancer, highlighting their diagnostic prognostic significance, well potential therapeutic targets. Despite initial setbacks developing broad-spectrum MMP inhibitors, recent advancements spurred interest more selective inhibitors that minimize off-target effects enhance efficacy. Furthermore, combining MMP-targeted therapies conventional treatments, chemotherapy immunotherapy, holds promise improving clinical outcomes. Future research directions include exploring novel regulatory mechanisms activity, integrating into personalized medicine approaches. field progresses, targeting may offer new avenues improve prognosis patients, making this promising area investigation.

Language: Английский

Citations

1
Retinal Inflammation and Reactive Müller Cells: Neurotrophins’ Release and Neuroprotective Strategies DOI Creative Commons
Bijorn Omar Balzamino, Andrea Cacciamani, Lucia Dinice

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(12), P. 1030 - 1030

Published: Dec. 9, 2024

Millions of people worldwide suffer from retinal disorders. Retinal diseases require prompt attention to restore function or reduce progressive impairments. Genetics, epigenetics, life-styling/quality and external environmental factors may contribute developing diseases. In the physiological retina, some glial cell types sustain neuron activities by guaranteeing ion homeostasis allowing effective interaction in synaptic transmission. Upon insults, cells interact with neuronal other non-neuronal cells, at least part counteracting biomolecular changes that trigger complications vision loss. Several epigenetic oxidative stress mechanisms are quickly activated release concert growth, fibrogenic angiogenic can influence overall microenvironment cell-to-cell response. Reactive Müller participate secreting neurotrophic/growth/angiogenic factors, cytokines/chemokines, cytotoxic/stress molecules neurogenic inflammation peptides. Any attempt maintain/restore condition be interrupted perpetuating vascular dysfunction neurodegeneration. Herein, we critically revise current knowledge on cell-to-mediator interplay between astrocytes microglia, respect pro-con modulators neuroprotective/detrimental activities, as observed using experimental models analyzing ocular fluids, altogether contributing a new point view field research precision medicine.

Language: Английский

Citations

1