Natural Product Research,
Journal Year:
2022,
Volume and Issue:
37(11), P. 1917 - 1934
Published: Sept. 12, 2022
Chronic
urticaria
(CU)
is
a
pathologic
condition
marked
by
the
emergence
of
wheals,
angioedema,
or
both
for
more
than
six
weeks.
The
improper
activation
and
degranulation
mast
cells
triggering
event,
which
results
in
production
various
mediators
such
as
histamine,
leukotrienes,
PAF,
chemokines,
cytokines.
Antihistamines
are
currently
most
common
pharmacological
treatment
urticaria,
but
corticosteroids
monoclonal
antibodies
can
also
be
employed.
Patients
who
have
been
taking
antihistamines
long
time
often
looking
alternatives.
Whole
plants,
portions
single
extracted
active
compounds
all
used
phytomedicine.
Plant
elements
frequently
combined
to
create
formulations
that
utilized
treat
variety
pathological
disorders.
Anti-inflammatory
and/or
anti-allergic
properties
found
several
herbs
regularly
herbal
formulations.
Antioxidant
present
some
constituents.
Exogenous
antioxidants
shown
improve
progression
autoimmune
disorders
numerous
studies.
aim
this
review
identify
chronic
characterize
their
efficacy,
mechanisms
action,
risk/benefit
ratio
comparison
western
treatment,
find
less
assess
therapeutic
safety
profile,
potential
wider
use.
Processes,
Journal Year:
2022,
Volume and Issue:
10(10), P. 1968 - 1968
Published: Sept. 29, 2022
Use
of
dyes
as
well
colorants
in
industrial
processes
has
extensively
increased.
Effluents
from
various
industries
such
textile,
paint,
food,
etc.
are
reported
to
have
a
diverse
range
colorants.
The
effluents
these
often
released
into
natural
water
bodies,
causing
serious
and
environmental
pollution,
which
humans
other
species
constantly
exposed.
Continued
changes
climate
also
affected
availability
for
people
around
the
world.
Thus,
advanced
treatments
removal
harmful
contaminants
municipal
wastewater
becoming
increasingly
important.
Removal
can
be
done
variety
ways,
including
physical,
chemical,
biological
treatments.
These
technologies,
however,
differ
terms
efficiency,
cost,
effect.
There
many
technological
economic
challenges
treatment
methods
currently
available.
search
most
suitable
strategy
successful
degradation
or
is
an
urgent
requirement.
Previously
published
research
suggests
that
use
enzymes
dye
more
effective
compared
traditional
techniques.
Nanoparticles,
with
their
exceptional
physicochemical
features,
potential
tackle
problem
purification
less
energy-intensive
way.
However,
extensive
standardization
would
necessity
different
nanoparticles.
Therefore,
intense
nanoparticle-based
technologies
may
provide
much
needed
solution
remediation
wastewater.
Biology,
Journal Year:
2022,
Volume and Issue:
11(9), P. 1366 - 1366
Published: Sept. 17, 2022
The
fish
intestine
operates
as
a
complicated
interface
between
the
organism
and
environment,
providing
biological
mechanical
protections
result
of
viscous
layer
mucus
released
by
goblet
cells,
which
serves
barrier
against
bacteria,
viruses,
other
pathogens,
contributes
to
functions
immune
system.
Therefore,
cells
have
role
in
preserving
health
body
secreting
acting
sentinels.
ancient
jawless
broadgilled
hagfish
(Eptatretus
cirrhatus,
Forster,
1801)
has
very
basic
digestive
system
because
it
lacks
stomach.
By
examining
presence,
localization,
co-localization
5-HT,
TLR2,
iNOS,
Piscidin1,
this
study
intends
provide
insight
into
potential
contributions
arranged
gut
hagfish.
Our
results
characterize
intestinal
hagfish,
for
first
time,
with
former
antibodies,
suggesting
hypothesis
conservation
roles
played
these
also
primitive
vertebrates.
Moreover,
deepens
knowledge
about
still
little-known
Zoological Letters,
Journal Year:
2023,
Volume and Issue:
9(1)
Published: March 4, 2023
Abstract
Metazoans
have
several
mechanisms
of
internal
defense
for
their
survival.
The
system
evolved
alongside
the
organisms.
Annelidae
circulating
coelomocytes
that
perform
functions
comparable
to
phagocytic
immune
cells
vertebrates.
Several
studies
shown
these
are
involved
in
phagocytosis,
opsonization,
and
pathogen
recognition
processes.
Like
vertebrate
macrophages,
permeate
organs
from
coelomic
cavity
capture
or
encapsulate
pathogens,
reactive
oxygen
species
(ROS),
nitric
oxide
(NO).
Furthermore,
they
produce
a
range
bioactive
proteins
response
detoxification
through
lysosomal
system.
Coelomocytes
can
also
participate
lithic
reactions
against
target
release
antimicrobial
peptides.
Our
study
immunohistochemically
identify
Lumbricus
terrestris
scattered
epidermal
connective
layer
below,
both
longitudinal
smooth
muscle
layer,
immunoreactive
TLR2,
CD14
α-Tubulin
first
time.
TLR2
not
fully
colocalized
with
each
other,
suggesting
may
belong
two
distinct
families.
expression
molecules
on
confirms
crucial
role
Oligochaeta
protostomes,
phylogenetic
conservation
receptors.
These
data
could
provide
further
insights
into
understanding
Annelida
complex
Biology,
Journal Year:
2022,
Volume and Issue:
11(11), P. 1653 - 1653
Published: Nov. 11, 2022
The
immune
system
of
a
fish
has
cellular
and
molecular
defense
mechanisms
that
are
substantially
retained
throughout
the
evolution
vertebrates.
innate
provides
biological
processes,
such
as
phagocytosis
mechanical
barriers,
to
implement
an
efficient
defensive
response
after
exposure
chemical
or
contaminants,
pollutants,
contact
with
parasites,
germs,
pathogens.
Club
cells
(CCs)
widespread
in
skin
Ostariophysi.
After
predator
attack
toxins
these
can
produce
alarming
substances.
Given
their
effectiveness
against
viruses,
common
lesions,
recent
studies
have
suggested
CCs
component
system.
This
study
aims
immunohistochemically
characterize
for
first
time
zebrafish,
using
mitogen-activated
protein
kinase
(MAPK)
p38,
Toll-like
receptor
(TLR)2,
Piscidin1,
inducible
nitric
oxide
synthase
(iNOS)
peptides
involved
function
all
types
vertebrate
cells.
According
our
analysis,
intermediate
layer
epidermis
exhibited
rounded,
oval,
elongated
CCs,
central
acidophilic
cytoplasm
spherical
basophilic
nucleus,
positive
antibodies
tested.
Our
results
may
confirm
could
be
function,
increasing
knowledge
teleosts.
Toxics,
Journal Year:
2022,
Volume and Issue:
10(11), P. 675 - 675
Published: Nov. 8, 2022
The
aims
of
this
study
were
to
measure
the
concentrations
selected
toxic
and
essential
elements
in
muscle
tissue
five
common
freshwater
fish
species
((roach
(Rutilus
rutilus),
bream
(Abramis
brama),
prussian
carp
(Carassius
gibelio),
crucian
carassius)
(Cyprinus
carpio))
from
Lake
Burgas
Mandra
(Bulgaria).
In
all
samples
levels
Cd,
Cr,
Cu,
Mn,
Ni,
Pb,
Fe
Zn
under
maximum
allowed
for
safe
human
consumption
Bulgaria
ranged
as
follows:
Cd
0.02-0.05;
Cr
0.03-0.06;
Cu
0.11-0.20;
Mn
0.05-0.71;
Ni
0.06-0.11;
Pb
0.15-0.27,
1.68-5.86
1.94-9.06
mg/kg
wet
weight.
concentration
As
was
detection
limit.
An
assessment
risk
by
calculation
target
hazard
quotients
(THQ),
index
(HI)
(TR)
performed.
quotient
(THQ)
individual
HI
combined
metals
lower
than
1,
indicating
no
health
consumers
due
intake
either
or
metals.
iAs,
below
10-6,
carcinogenic
risk.
According
these
results,
is
health.
Biology,
Journal Year:
2025,
Volume and Issue:
14(1), P. 77 - 77
Published: Jan. 15, 2025
Anthropic
activities
have
significantly
elevated
cadmium
levels,
making
it
a
significant
stressor
in
aquatic
ecosystems.
Present
high
concentrations
across
water
bodies,
is
known
to
bioaccumulate
and
biomagnify
throughout
the
food
chain.
While
toxic
effects
of
on
organs
tissues
species
are
well-documented,
little
about
its
impact
sensory
systems
crucial
for
survival.
Consequently,
this
study
investigated
short-term
exposure
(96
h)
25
µM
chloride
olfactory
system
adult
zebrafish.
The
research
aimed
assess
structural
functional
changes
zebrafish's
lamellae,
providing
deeper
understanding
how
affects
sense
smell
species.
After
exposure,
cyto-anatomical
alterations
lamellae
were
analysed
using
light
microscopy
immunocytochemistry.
They
revealed
severe
lamellar
edema,
epithelial
thickening,
an
increased
number
apoptotic
crypt
cells.
Rodlet
goblet
cells
also
by
3.5-
2.5-fold,
respectively,
compared
control
collagen
density
lamina
propria
1.7-fold.
Cadmium
upregulated
metallothioneins
PCNA-positive
function
was
assessed
through
behavioural
odour
recognition
test,
followed
recovery
phase
which
zebrafish
exposed
placed
clean
six
days.
fish
performed
poorly,
failing
reach
five
consecutive
trials.
However,
damage
reduced
after
period,
their
performance
improved,
becoming
comparable
group.
These
results
suggest
that
disrupts
smell,
possible
exposure.
This
evidence
sheds
aspects
animal
survival
often
overlooked
when
assessing
environmental
pollution.