The Science of The Total Environment,
Journal Year:
2024,
Volume and Issue:
947, P. 174766 - 174766
Published: July 14, 2024
In
the
real
environment,
some
chemical
functional
groups
are
unavoidably
combined
on
nanoplastic
surface.
Reportedly,
amino-modified
polystyrene
nanoparticles
(PS-A
NPs)
exposure
in
parents
can
induce
severe
transgenerational
toxicity,
but
underlying
molecular
mechanisms
remain
largely
unclear.
Using
Caenorhabditis
elegans
as
animal
model,
this
study
was
performed
to
investigate
role
of
germline
epidermal
growth
factor
(EGF)
signal
modulating
PS-A
NPs'
toxicity.
As
a
result,
1–10
μg/L
NPs
transgenerationally
enhanced
EGF
ligand/LIN-3
and
NSH-1
levels.
Germline
RNAi
lin-3
nsh-1
resistant
against
implying
involvement
ligand
activation
inducing
Furthermore,
LIN-3
overexpression
receptor/LET-23
expression
progeny,
let-23
F1-generation
notably
suppressed
toxicity
exposed
worms
overexpressing
at
P0
generation.
Finally,
LET-23
functioned
neurons
intestine
for
regulating
acted
upstream
DAF-16/FOXO
within
response
neurons,
DAF-7/DBL-1,
ligands
TGF-β
signals,
mediate
Briefly,
work
revealed
risk
which
regulated
through
activating
organisms.
Environmental Science & Technology,
Journal Year:
2023,
Volume and Issue:
57(48), P. 19295 - 19303
Published: Nov. 8, 2023
N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine
(6-PPD),
one
of
the
most
common
additives
used
in
rubber,
enters
environment
due
to
significant
emissions
tire
wear
particles.
6-PPD
quinone
(6-PPDQ)
is
an
important
derivative
after
ozonization.
With
concentrations
ranging
from
nanograms
per
liter
μg/L,
6-PPDQ
has
so
far
been
identified
a
series
water
samples.
Acute
lethality
coho
salmon
(LC50
<
1
μg/L)
was
lower
than
environmental
6-PPDQ,
highlighting
exposure
risks
6-PPDQ.
It
becoming
increasingly
necessary
investigate
potential
toxicity
at
concentrations.
Here,
we
examined
effect
on
lifespan
and
healthspan
underlying
mechanism
Caenorhabditis
elegans.
Exposure
(1
10
shortened
lifespan.
Meanwhile,
during
aging
process,
(0.1–10
could
decrease
both
pumping
rate
locomotion
behavior,
suggesting
healthspan.
For
molecular
mechanism,
dysregulation
insulin
signaling
pathway
linked
In
pathway,
DAF-2
restricted
function
DAF-16
activate
downstream
targets
(SOD-3
HSP-6),
which
turn
controlled
Additionally,
response
toxicity,
peptides
(INS-6,
INS-7,
DAF-28)
corresponding
receptor
DAF-2.
Therefore,
environmentally
relevant
potentially
causes
damage
by
activating
organisms.
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
272, P. 116056 - 116056
Published: Feb. 1, 2024
Using
Caenorhabditis
elegans
as
animal
model,
we
investigated
the
effect
of
exposure
to
polystyrene
nanoparticles
(PS-NPs)
in
range
μg/L
on
high
glucose
toxicity
induction.
With
lifespan
and
locomotion
behavior
endpoints,
observed
that
PS-NP
(10
100
μg/L)
enhanced
50
mM
treated
animals.
In
insulin
signaling
pathway,
expressions
genes
encoding
receptor
(daf-2),
kinases
(age-1
akt-1/2),
peptides
(ins-9,
ins-6,
daf-28)
were
increased,
daf-16
its
target
sod-3
decreased
nematodes
followed
by
exposure.
Toxicity
enhancement
was
inhibited
RNAi
daf-2,
age-1,
akt-2,
akt-1,
3
genes,
but
increased
sod-3.
The
resistance
animals
with
daf-2
could
be
suppressed
daf-16.
Moreover,
exposure,
expression
ins-9,
daf-28.
Our
data
demonstrated
risk
enhancing
toxicity.
More
importantly,
alteration
pathway
associated
