Preliminary Study to Investigate Possible Cyto-Genotoxic and Oxidative Effects of Few-Layer Graphene in Human Bronchial Cells DOI Open Access

Anna Maria Fresegna,

Aureliano Ciervo,

Cinzia Lucia Ursini

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13515 - 13515

Published: Dec. 17, 2024

Graphene and its various derivatives, known as graphene-based nanomaterials (GBNs), hold tremendous potential across many fields due to their exceptional properties. As with any novel material, concerns about safety have emerged alongside widespread production use. Several studies shown that GBNs can diverse effects on cell lines organisms under different exposure conditions. This study intends evaluate the toxicity of few-layer graphene (FLG) in human bronchial BEAS-2B. Cells were exposed concentrations FLG for 24 h, cyto-genotoxic, oxidative, inflammatory evaluated. We found an increase cytotoxicity terms death, apoptosis, membrane damage at highest concentration. also detected a slight direct DNA percentage comets. Oxidative was observed did not induce notable cytokine release. Overall, this suggests cytotoxicity, BEAS-2B, particularly high concentrations. These findings contribute better understanding health highlight importance considering dose-dependent when assessing GBNs.

Language: Английский

Strategies, Challenges, and Prospects of Nanoparticles in Gynecological Malignancies DOI Creative Commons
Y X Zhang,

Jing Tian

ACS Omega, Journal Year: 2024, Volume and Issue: 9(36), P. 37459 - 37504

Published: Aug. 23, 2024

Gynecologic cancers are a significant health issue for women globally. Early detection and successful treatment of these tumors crucial the survival female patients. Conventional therapies often ineffective harsh, particularly in advanced stages, necessitating exploration new therapy options. Nanotechnology offers novel approach to biomedicine. A biosensor utilizing bionanotechnology can be employed early tumor identification due distinctive physical chemical characteristics nanoparticles. Nanoparticles have been rapidly applied field gynecologic malignancies, leading advancements recent years. This study highlights significance nanoparticles treating gynecological cancers. It focuses on using precise diagnosis continuous monitoring disease, innovative imaging, analytic methods, as well multifunctional drug delivery systems targeted therapies. review examines several nanocarrier systems, such dendrimers, liposomes, nanocapsules, nanomicelles, malignancies. The also enhanced therapeutic potential ligand-functionalized nanoformulations compared nonfunctionalized anoformulations. In conclusion, text discusses constraints future prospects chemotherapeutics. will offer methods diagnosing

Language: Английский

Citations

2

Unravelling the toxicity of carbon nanomaterials – From cellular interactions to mechanistic understanding DOI

Bveledzani P. Makhado,

Adewale O. Oladipo, Nozipho N. Gumbi

et al.

Toxicology in Vitro, Journal Year: 2024, Volume and Issue: 100, P. 105898 - 105898

Published: July 17, 2024

Language: Английский

Citations

1

Measurement of Aerosol Particles from Vibrated Lab Coats DOI Creative Commons
Byung Uk Lee

Toxics, Journal Year: 2024, Volume and Issue: 12(8), P. 565 - 565

Published: Aug. 2, 2024

A study was conducted to measure aerosol particles emitted from laboratory coats (lab coats) under vibration, comparing them with a suit and shirt. This focused on ranging 0.3 μm >10 μm. Experimental results showed that lab coat vibration increased >5 while reducing submicron particles. The (old used) exhibited greater particle concentration variations compared those using the new or Contrastingly, did not significantly affect concentrations. These findings highlight impact of concentrations in surrounding air, which is important for work environments.

Language: Английский

Citations

0

Preliminary Study to Investigate Possible Cyto-Genotoxic and Oxidative Effects of Few-Layer Graphene in Human Bronchial Cells DOI Open Access

Anna Maria Fresegna,

Aureliano Ciervo,

Cinzia Lucia Ursini

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13515 - 13515

Published: Dec. 17, 2024

Graphene and its various derivatives, known as graphene-based nanomaterials (GBNs), hold tremendous potential across many fields due to their exceptional properties. As with any novel material, concerns about safety have emerged alongside widespread production use. Several studies shown that GBNs can diverse effects on cell lines organisms under different exposure conditions. This study intends evaluate the toxicity of few-layer graphene (FLG) in human bronchial BEAS-2B. Cells were exposed concentrations FLG for 24 h, cyto-genotoxic, oxidative, inflammatory evaluated. We found an increase cytotoxicity terms death, apoptosis, membrane damage at highest concentration. also detected a slight direct DNA percentage comets. Oxidative was observed did not induce notable cytokine release. Overall, this suggests cytotoxicity, BEAS-2B, particularly high concentrations. These findings contribute better understanding health highlight importance considering dose-dependent when assessing GBNs.

Language: Английский

Citations

0