Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
164, P. 114955 - 114955
Published: June 1, 2023
Bioactive
natural
products
(BNPs)
are
the
marrow
of
medicinal
plants,
which
secondary
metabolites
organisms
and
have
been
most
famous
drug
discovery
database.
for
their
enormous
number
great
safety
in
medical
applications.
However,
BNPs
troubled
by
poor
druggability
compared
with
synthesis
drugs
challenged
as
medicine
(only
a
few
applied
clinical
settings).
In
order
to
find
reasonable
solution
improving
BNPs,
this
review
summarizes
bioactive
nature
based
on
pharmacological
research
tries
explain
reasons
BNPs.
And
then
focused
boosting
loaded
delivery
systems,
further
concludes
advantages
systems
improvement
from
perspective
nature,
discusses
why
need
predicts
next
direction.
Frontiers in Oncology,
Journal Year:
2021,
Volume and Issue:
11
Published: Nov. 15, 2021
Background
Cancer
stem
cells
(CSCs)
are
able
to
survive
after
cancer
therapies,
resulting
in
tumor
progression
and
recurrence,
as
is
seen
colorectal
cancer.
Therapies
targeting
CSCs
regarded
novel
promising
strategies
for
efficiently
eradicating
tumors.
Berberine,
an
isoquinoline
alkaloid
extracted
from
the
Chinese
herbal
medicine
Coptis
chinensis,
was
found
have
antitumor
activities
against
cancer,
without
knowing
whether
it
exerts
inhibitory
effects
on
potential
mechanisms.
Methods
In
this
study,
we
examined
roles
of
Berberine
derived
HCT116
HT29
by
culturing
serum-free
medium.
We
also
m
6
A
methylation
via
regulating
fat
mass
obesity-associated
protein
(FTO),
downregulating
β-catenin.
Results
tumorigenicity,
growth,
stemness
stem-like
cells.
The
regulatory
effect
N6-methyladenosine
(m
A),
abundant
mRNA
modification,
examined.
treatment
decreased
cell
proliferation
decreasing
cyclin
D1
increasing
p27
p21
subsequently
induced
cycle
arrest
at
G
1
/G
0
phase.
colony
formation
apoptosis.
transcriptionally
increased
FTO
thus
methylation,
which
reversed
both
knockdown
addition
inhibitor
FB23-2.
FTO-related
decreases
CSCs.
chemosensitivity
promoted
chemotherapy
agent-induced
Moreover,
that
β-catenin,
a
negative
regulator
FTO.
Conclusions
Our
observation
effectively
β-catenin
suggests
role
modulating
malignant
behaviors
Chemical Biology & Drug Design,
Journal Year:
2023,
Volume and Issue:
102(1), P. 177 - 200
Published: March 11, 2023
Abstract
Berberine
(BBR)
is
a
potential
plant
metabolite
and
has
remarkable
anticancer
properties.
Many
kinds
of
research
are
being
focused
on
the
cytotoxic
activity
berberine
in
vitro
vivo
studies.
A
variety
molecular
targets
which
lead
to
effect
ranges
from
p‐53
activation,
Cyclin
B
expression
for
arresting
cell
cycles;
protein
kinase
(AKT),
MAP
IKB
antiproliferative
activity;
beclin‐1
involved
autophagy;
reduced
MMP‐9
MMP‐2
inhibition
invasion
metastasis
etc.
also
interferes
with
transcription
factor‐1
(AP‐1)
responsible
oncogenes
neoplastic
transformation
cell.
It
leads
various
enzymes
directly
or
indirectly
carcinogenesis
like
N
acetyl
transferase,
Cyclo‐oxygenase‐2,
Telomerase
Topoisomerase.
In
addition
these
actions,
plays
role
in,
regulation
reactive
oxygen
species
inflammatory
cytokines
preventing
cancer
formation.
properties
demonstrated
due
interaction
micro‐RNA.
The
summarized
information
presented
this
review
article
may
help
researchers,
scientists/industry
persons
use
as
promising
candidate
against
cancer.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
164, P. 114955 - 114955
Published: June 1, 2023
Bioactive
natural
products
(BNPs)
are
the
marrow
of
medicinal
plants,
which
secondary
metabolites
organisms
and
have
been
most
famous
drug
discovery
database.
for
their
enormous
number
great
safety
in
medical
applications.
However,
BNPs
troubled
by
poor
druggability
compared
with
synthesis
drugs
challenged
as
medicine
(only
a
few
applied
clinical
settings).
In
order
to
find
reasonable
solution
improving
BNPs,
this
review
summarizes
bioactive
nature
based
on
pharmacological
research
tries
explain
reasons
BNPs.
And
then
focused
boosting
loaded
delivery
systems,
further
concludes
advantages
systems
improvement
from
perspective
nature,
discusses
why
need
predicts
next
direction.
