Epigenomes,
Journal Year:
2022,
Volume and Issue:
6(3), P. 27 - 27
Published: Aug. 26, 2022
Cannabis
is
one
of
the
most
commonly
used
and
abused
illicit
drugs
in
world
today.
The
United
States
(US)
currently
has
highest
annual
prevalence
rate
cannabis
consumption
world,
17.9%
individuals
aged
12
or
older,
it
on
rise.
With
increasing
use
comes
potential
for
an
increase
abuse,
according
to
Substance
Abuse
Mental
Health
Services
Administration
(SAMHSA),
approximately
5.1%
Americans
had
Use
Disorder
(CUD)
2020.
Research
shown
that
genetics
epigenetics
play
a
significant
role
CUD.
In
fact,
50–70%
liability
CUD
40–48%
initiation
have
been
found
be
result
genetic
factors.
usage
also
linked
increased
risk
psychiatric
disorders
Reward
Deficiency
Syndrome
(RDS)
subsets
like
schizophrenia,
depression,
anxiety,
substance
disorder.
Comprehension
epigenetic
aspects
cannabinoids
necessary
future
research,
treatment
plans,
production
pure
cannabinoid
compounds,
which
will
essential
FDA
approval.
conclusion,
having
better
understanding
underpinnings
use,
CUD,
endocannabinoid
system
as
whole
aid
development
effective
FDA-approved
therapies
advancement
personalized
medicine.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(16), P. 8576 - 8576
Published: Aug. 9, 2021
Cannabis
use
during
pregnancy
has
continued
to
rise,
particularly
in
developed
countries,
as
a
result
of
the
trend
towards
legalization
and
lack
consistent,
evidence-based
knowledge
on
matter.
While
there
is
conflicting
data
regarding
whether
cannabis
leads
adverse
outcomes
such
stillbirth,
preterm
birth,
low
birthweight,
or
increased
admission
neonatal
intensive
care
units,
investigations
into
long-term
effects
offspring's
health
are
limited.
Historically,
studies
have
focused
neurobehavioral
prenatal
exposure
offspring.
The
other
physiological
aspects
developing
fetus
received
less
attention.
Importantly,
our
about
cannabinoid
signaling
placenta
also
endocannabinoid
system
(ECS)
present
at
early
stages
development
represents
potential
target
for
exogenous
cannabinoids
utero.
ECS
expressed
broad
range
tissues
influences
spectrum
cellular
functions.
aim
this
review
explore
current
evidence
surrounding
role
fetus.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(5), P. 2672 - 2672
Published: Feb. 28, 2022
Receptors
are
macromolecules
that
transmit
information
regulating
cell
proliferation,
differentiation,
migration
and
apoptosis,
play
key
roles
in
oncogenic
processes
correlate
with
the
prognoses
of
cancer
patients.
Thus,
targeting
receptors
to
constrain
development
progression
has
gained
widespread
interest.
Small
molecule
compounds
natural
origin
have
been
widely
used
as
drugs
or
adjuvant
chemotherapeutic
agents
therapies
due
their
activities
selectively
killing
cells,
alleviating
drug
resistance
mitigating
side
effects.
Meanwhile,
many
compounds,
including
those
receptors,
still
under
laboratory
investigation
for
anti-cancer
mechanisms.
In
this
review,
we
classify
by
structures
functions,
illustrate
these
discuss
mechanisms
activities.
We
aim
provide
primary
knowledge
mechanistic
regulation
clinical
applications
through
deregulated
receptors.
Comprehensive Reviews in Food Science and Food Safety,
Journal Year:
2024,
Volume and Issue:
23(5)
Published: Sept. 1, 2024
Abstract
Cannabis‐infused
foods
are
currently
on
the
rise
in
markets
all
around
world.
Meanwhile,
there
concerns
over
health
implications
for
consumers.
Studies
have
explored
therapeutic
potential
and
nutritional
economic
benefits
of
cannabis
usage.
Yet,
phytonutrients,
processing
methods,
cannabis‐infused
not
been
well
explored.
This
review
evaluates
existing
evidence
nutritional,
processing,
safety,
phytonutrient
composition
food
products
their
medicinal
functional
prospects.
Cannabis
seeds
contain
highest
amount
dietary
nutrients,
while
flowers
bioactive
constituents.
Oils,
butter,
seeds,
flowers,
leaf
extracts
plant
forms
incorporated
into
such
as
beverages,
baked
products,
cooking
ingredients,
foods,
nutraceuticals,
nootropics.
found
to
offer
pain
management,
brain
function,
gut
health,
certain
cancers.
Findings
also
show
significant
constraints
associated
with
regarding
dosage
guidelines,
limited
research,
efficacy,
long‐term
effects
is
further
worsened
by
lack
policies
that
regulate
industry.
To
realize
full
use
industries
regulatory
guidelines
needed
control
dosages
improve
its
efficient
these
industries.
will
go
a
long
way
ensure
safety
users
enhance
responsible
production,
marketing,
distribution.
Epigenomes,
Journal Year:
2022,
Volume and Issue:
6(3), P. 27 - 27
Published: Aug. 26, 2022
Cannabis
is
one
of
the
most
commonly
used
and
abused
illicit
drugs
in
world
today.
The
United
States
(US)
currently
has
highest
annual
prevalence
rate
cannabis
consumption
world,
17.9%
individuals
aged
12
or
older,
it
on
rise.
With
increasing
use
comes
potential
for
an
increase
abuse,
according
to
Substance
Abuse
Mental
Health
Services
Administration
(SAMHSA),
approximately
5.1%
Americans
had
Use
Disorder
(CUD)
2020.
Research
shown
that
genetics
epigenetics
play
a
significant
role
CUD.
In
fact,
50–70%
liability
CUD
40–48%
initiation
have
been
found
be
result
genetic
factors.
usage
also
linked
increased
risk
psychiatric
disorders
Reward
Deficiency
Syndrome
(RDS)
subsets
like
schizophrenia,
depression,
anxiety,
substance
disorder.
Comprehension
epigenetic
aspects
cannabinoids
necessary
future
research,
treatment
plans,
production
pure
cannabinoid
compounds,
which
will
essential
FDA
approval.
conclusion,
having
better
understanding
underpinnings
use,
CUD,
endocannabinoid
system
as
whole
aid
development
effective
FDA-approved
therapies
advancement
personalized
medicine.
