Mycotoxin Research, Journal Year: 2024, Volume and Issue: 40(4), P. 651 - 658
Published: Aug. 20, 2024
Language: Английский
Toxins, Journal Year: 2024, Volume and Issue: 16(1), P. 31 - 31
Published: Jan. 8, 2024
The term "Fusarium Head Blight" (FHB) resistance supposedly covers common resistances to different
Language: Английский
Citations
19
Poultry Science, Journal Year: 2024, Volume and Issue: 103(3), P. 103471 - 103471
Published: Jan. 17, 2024
Contamination of feed with mycotoxins has become a severe issue worldwide. Among the most prevalent trichothecene mycotoxins, T-2 toxin is particular importance for livestock production, including poultry posing significant threat to animal health and productivity. This review article aims comprehensively analyze pathological consequences, metabolism, toxic effects in poultry. Trichothecene primarily produced by Fusarium species, are notorious their potent toxicity. exhibits broad spectrum negative on leading substantial economic losses as well concerns about welfare food safety modern agriculture. exposure easily results consequences gastrointestinal tract, parenchymal tissues like liver (as key organ its metabolism), kidneys, or reproductive organs. In addition, it also intensely damages immune system-related such spleen, bursa Fabricius, thymus causing immunosuppression increasing susceptibility animals infectious diseases, making immunization programs less effective. The cellular processes transcriptional translational levels induces apoptosis through activation numerous signaling cascades. Furthermore, according recent studies, besides direct abovementioned processes, production reactive molecules free radicals resulting oxidative distress concomitantly occurring damage. conclusion, this provides complex detailed overview mechanism action immunomodulatory stress-related toxin. Understanding these crucial developing strategies mitigate impact avian future.
Language: Английский
Citations
17
Toxins, Journal Year: 2024, Volume and Issue: 16(6), P. 249 - 249
Published: May 27, 2024
Mycotoxins, secondary metabolites synthesized by various filamentous fungi genera such as Aspergillus, Penicillium, Fusarium, Claviceps, and Alternaria, are potent toxic compounds. Their production is contingent upon specific environmental conditions during fungal growth. Arising byproducts of metabolic processes, mycotoxins exhibit significant toxicity, posing risks acute or chronic health complications. Recognized highly hazardous food contaminants, present a pervasive threat throughout the agricultural processing continuum, from plant cultivation to post-harvest stages. The imperative adhere principles good industrial practice underscored mitigate risk mycotoxin contamination in production. In domain safety, rapid efficient detection holds paramount significance. This paper delineates conventional commercial methodologies for ensuring encompassing techniques like liquid chromatography, immunoassays, test strips, with emphasis on role electrochemiluminescence (ECL) biosensors, which known their high sensitivity specificity. These categorized into antibody-, aptamer-based, well molecular imprinting methods. examines latest advancements biosensors testing, particular focus amplification strategies operating mechanisms.
Language: Английский
Citations
10
Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 27, 2025
T-2 toxin is a highly toxic fungal that threatens humans and animals' health. As major detoxifying metabolic organ, the kidney also target of toxin. This article reviews nephrotoxicity research progress, covering renal structure function damage, mechanisms, detoxification methods to future directions. damages structure, causing dysfunction. The mechanism involves multiple factors including oxidative stress, endoplasmic reticulum mitophagy, inflammatory responses, apoptosis, which are intertwined interdependent. Current strategies mainly involve reducing in feedstuff using antioxidant substances, but both have limits. Future should focus on cells sensitivity toxin, exploring key molecules toxin's nephrotoxicity, injury's impact other organs, better methods. review aims guide underpin toxin-induced prevention treatment.
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 25(1), P. 553 - 553
Published: Dec. 31, 2023
Zearalenone (ZEA) is present worldwide as a serious contaminant of food and feed causes male reproductive toxicity. The implication paraptosis, which nonclassical paradigm cell death, unclear in ZEA-induced disorders. In this study, the toxic effects ZEA on blood-testis barrier (BTB) related mechanisms paraptosis were detected goats. exposure, vivo, caused significant decrease spermatozoon quality, destruction seminiferous tubules, damage to BTB integrity. Furthermore, exposure Sertoli cells (SCs) vitro showed similar dysfunction structure function. Importantly, formation massive cytoplasmic vacuoles ZEA-treated SCs corresponded highly swollen dilative endoplasmic reticulum (ER), inhibition significantly alleviated SC death vacuolization, indicated important contribution damage. Meanwhile, expression ER stress marker proteins was increased after treatment but decreased under paraptosis. vacuole induced by ZEA, remarkably blocked inhibition. conclusion, these results facilitate exploration involved
Language: Английский
Citations
16
Heliyon, Journal Year: 2023, Volume and Issue: 9(11), P. e22388 - e22388
Published: Nov. 1, 2023
Aflatoxin B1 (AFB1) contamination seriously threatens nutritional safety and common health. Bacterial CotA-laccases have great potential to degrade AFB1 without redox mediators. However, are limited because of the low catalytic activity as spore-bound nature. The degradation ability CotA-laccase from Bacillus licheniformis ANSB821 has been reported by a previous study in our laboratory. In this study, Q441A mutant was constructed enhance AFB1. After site-directed mutation, showed 1.73-fold higher efficiency (kcat/Km) towards than wild-type did. rate that pH range 5.0 9.0. addition, thermostability improved after mutation. Based on structure analysis CotA-laccase, for may be due smaller steric hindrance Ala441 Gln441. This is first research with mutagenesis. summary, will suitable candidate highly effective detoxification future.
Language: Английский
Citations
9
Published: Jan. 1, 2024
Citations
1
Mycotoxin Research, Journal Year: 2024, Volume and Issue: 40(4), P. 651 - 658
Published: Aug. 20, 2024
Language: Английский
Citations
0