Dietary Mycotoxins: An Overview on Toxicokinetics, Toxicodynamics, Toxicity, Epidemiology, Detection, and Their Mitigation with Special Emphasis on Aflatoxicosis in Humans and Animals DOI Creative Commons
James Karuku Kibugu, Leonard Munga, David Mburu

et al.

Toxins, Journal Year: 2024, Volume and Issue: 16(11), P. 483 - 483

Published: Nov. 8, 2024

Mycotoxins are secondary metabolites of filamentous fungi and ubiquitous dietary contaminants. Aflatoxins, a group mycotoxins with high prevalence toxicity, have raised level public health concern, the most prevalent toxic being aflatoxin B1 (AFB1). Many aspects appertaining to AFB1 poisoning not well understood. Yet this information is necessary devise appropriate surveillance mitigation strategies against human animal aflatoxicosis. This review provides an in-depth update work carried out on mycotoxin poisoning, particularly aflatoxicosis in humans animals, identify gaps knowledge. Hypotheses explaining functional significance fungal biology their epidemiological data presented briefly discussed. The toxicology aflatoxins challenges discussed depth. It was concluded that identification potential mycotoxin-hazard-prone food items quantification associated risk cancer ailments prime priority. There dearth reliable sampling methodologies for estimating feed. Data feed its implication production, strategies, elucidation factors hazard required. To reduce burden aflatoxins, employing predictive technology, biocontrol seem promising approaches.

Language: Английский

Preparation of Soybean Dreg-Based Biochar@TiO2 Composites and the Photocatalytic Degradation of Aflatoxin B1 Exposed to Simulated Sunlight Irradiation DOI Creative Commons
Jian Zhang,

Zhiwei Ying,

He Li

et al.

Toxins, Journal Year: 2024, Volume and Issue: 16(10), P. 429 - 429

Published: Oct. 5, 2024

Aflatoxin B

Language: Английский

Citations

4
A Comprehensive Review of Mycotoxins, Their Toxicity, and Innovative Detoxification Methods DOI Creative Commons
Ravikant Shekhar, Vinay B. Raghavendra,

P. Rachitha

et al.

Toxicology Reports, Journal Year: 2025, Volume and Issue: 14, P. 101952 - 101952

Published: Feb. 7, 2025

A comprehensive overview of food mycotoxins, their toxicity, and contemporary detoxification techniques is given in this article. Mycotoxins, which are harmful secondary metabolites generated by a variety fungi, including Fusarium, Aspergillus, Penicillium, provide serious health concerns to humans animals. These include hepatotoxicity, neurotoxicity, carcinogenicity. Mycotoxins commonly found basic products, as evidenced recent studies, raising worries about public safety. The article discusses detection such enzyme-linked immunosorbent assays (ELISA), quick strip tests. Moreover, the use various control systems associated with mycotoxinis highlighted. In addition, novel strategies nanotechnology, plant extracts, omics studies were also discussed. When taken whole, analysis helps clarify pressing need for efficient management monitoring prevent mycotoxin contamination chain.

Language: Английский

Citations

0
Assessment of total aflatoxin in selected crops using enzyme-linked immunosorbent assay (ELISA): A sustainable monitoring and control of aflatoxin in both rural and urban areas in Nigeria DOI
J. N. Akinniyi

Deleted Journal, Journal Year: 2025, Volume and Issue: 32(1), P. 65 - 76

Published: Feb. 1, 2025

Aflatoxins, toxic compounds from Aspergillus fungi, pose serious health and economic risks in Africa, mainly due to contamination staple foods. This study investigated aflatoxin maize, cowpeas, melon seeds, groundnuts, yam chips collected Lagos, Nigeria, examined the effectiveness of processing methods reduce levels. One hundred fifty samples were gathered three markets using coning quartering techniques. Samples processed by washing, aeration, drying below 50°C for six hours a multi-purpose dryer. Moisture total levels then measured. Each sample was extracted with 70% methanol analyzed Ridascreen® enzyme-linked immunosorbent assay (ELISA) kit (n=45). Method validation showed strong recovery known concentration, detection quantification limits at 1.87 μg/kg 3.41 μg/kg, respectively. Unprocessed ranging 3.10-10.20 while ranged 2.00-5.10 μg/kg; maize exceeded National Agency Food Drug Administration Control limit 10 raw Statistical analysis (one-way ANOVA Tukey’s post-hoc test) confirmed that significantly reduced (p<0.05). offers valuable data, supporting agricultural research informing Nigerian policies on food safety promote public stability.

Language: Английский

Citations

0
Dietary Mycotoxins: An Overview on Toxicokinetics, Toxicodynamics, Toxicity, Epidemiology, Detection, and Their Mitigation with Special Emphasis on Aflatoxicosis in Humans and Animals DOI Creative Commons
James Karuku Kibugu, Leonard Munga, David Mburu

et al.

Toxins, Journal Year: 2024, Volume and Issue: 16(11), P. 483 - 483

Published: Nov. 8, 2024

Mycotoxins are secondary metabolites of filamentous fungi and ubiquitous dietary contaminants. Aflatoxins, a group mycotoxins with high prevalence toxicity, have raised level public health concern, the most prevalent toxic being aflatoxin B1 (AFB1). Many aspects appertaining to AFB1 poisoning not well understood. Yet this information is necessary devise appropriate surveillance mitigation strategies against human animal aflatoxicosis. This review provides an in-depth update work carried out on mycotoxin poisoning, particularly aflatoxicosis in humans animals, identify gaps knowledge. Hypotheses explaining functional significance fungal biology their epidemiological data presented briefly discussed. The toxicology aflatoxins challenges discussed depth. It was concluded that identification potential mycotoxin-hazard-prone food items quantification associated risk cancer ailments prime priority. There dearth reliable sampling methodologies for estimating feed. Data feed its implication production, strategies, elucidation factors hazard required. To reduce burden aflatoxins, employing predictive technology, biocontrol seem promising approaches.

Language: Английский

Citations

1