Antibiotic Resistance in the Elderly: Mechanisms, Risk Factors, and Solutions DOI Creative Commons
Nikolaos Theodorakis, Georgios Feretzakis, Christos Hitas

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(10), P. 1978 - 1978

Published: Sept. 30, 2024

Antibiotic resistance presents a critical challenge in healthcare, particularly among the elderly, where multidrug-resistant organisms (MDROs) contribute to increased morbidity, mortality, and healthcare costs. This review focuses on mechanisms underlying key bacterial pathogens highlights how aging-related factors like immunosenescence, frailty, multimorbidity increase burden of infections from MDROs this population. Novel strategies mitigate include development next-generation antibiotics teixobactin cefiderocol, innovative therapies such as bacteriophage therapy antivirulence treatments, implementation antimicrobial stewardship programs optimize antibiotic use. Furthermore, advanced molecular diagnostic techniques, including nucleic acid amplification tests sequencing, allow for faster more precise identification resistant pathogens. Vaccine development, through approaches multi-epitope vaccines nanoparticle-based platforms, holds promise preventing MDRO elderly. The role machine learning (ML) predicting patterns aiding vaccine is also explored, offering promising solutions personalized treatment prevention By integrating cutting-edge diagnostics, therapeutic innovations, ML-based approaches, underscores importance multidisciplinary efforts address global aging populations.

Language: Английский

Phage therapy: From biological mechanisms to future directions DOI Creative Commons
Steffanie A. Strathdee, Graham F. Hatfull, Vivek K. Mutalik

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(1), P. 17 - 31

Published: Jan. 1, 2023

Increasing antimicrobial resistance rates have revitalized bacteriophage (phage) research, the natural predators of bacteria discovered over 100 years ago. In order to use phages therapeutically, they should (1) preferably be lytic, (2) kill bacterial host efficiently, and (3) fully characterized exclude side effects. Developing therapeutic takes a coordinated effort multiple stakeholders. Herein, we review state art in phage therapy, covering biological mechanisms, clinical applications, remaining challenges, future directions involving naturally occurring genetically modified or synthetic phages.

Language: Английский

Citations

377
Considerations for the Use of Phage Therapy in Clinical Practice DOI Creative Commons
Gina A. Suh, Thomas P. Lodise, Pranita D. Tamma

et al.

Antimicrobial Agents and Chemotherapy, Journal Year: 2022, Volume and Issue: 66(3)

Published: Jan. 18, 2022

Increasing antimicrobial resistance and medical device-related infections have led to a renewed interest in phage therapy as an alternative or adjunct conventional antimicrobials. Expanded access compassionate use cases risen exponentially but varied widely approach, methodology, clinical situations which might be considered, dosing, route of administration, outcomes.

Language: Английский

Citations

268
Pseudomonas aeruginosa: Infections, Animal Modeling, and Therapeutics DOI Creative Commons
Stephen Wood, Timothy M. Kuzel, Sasha H. Shafikhani

et al.

Cells, Journal Year: 2023, Volume and Issue: 12(1), P. 199 - 199

Published: Jan. 3, 2023

is an important Gram-negative opportunistic pathogen which causes many severe acute and chronic infections with high morbidity, mortality rates as 40%. What makes

Language: Английский

Citations

134
Current Clinical Landscape and Global Potential of Bacteriophage Therapy DOI Creative Commons
Nicole Hitchcock, Danielle Devequi Gomes Nunes, Job Shiach

et al.

Viruses, Journal Year: 2023, Volume and Issue: 15(4), P. 1020 - 1020

Published: April 21, 2023

In response to the global spread of antimicrobial resistance, there is an increased demand for novel and innovative antimicrobials. Bacteriophages have been known their potential clinical utility in lysing bacteria almost a century. Social pressures concomitant introduction antibiotics mid-1900s hindered widespread adoption these naturally occurring bactericides. Recently, however, phage therapy has re-emerged as promising strategy combatting resistance. A unique mechanism action cost-effective production promotes phages ideal solution addressing antibiotic-resistant bacterial infections, particularly lower- middle-income countries. As number phage-related research labs worldwide continues grow, it will be increasingly important encourage expansion well-developed trials, standardization storage cocktails, advancement international collaboration. this review, we discuss history, benefits, limitations bacteriophage its current role setting resistance with specific focus on active trials case reports administration.

Language: Английский

Citations

93
Drug delivery strategies for antibiofilm therapy DOI
Victor Choi, Jennifer Rohn, Paul Stoodley

et al.

Nature Reviews Microbiology, Journal Year: 2023, Volume and Issue: 21(9), P. 555 - 572

Published: May 31, 2023

Language: Английский

Citations

70
Translating phage therapy into the clinic: Recent accomplishments but continuing challenges DOI Creative Commons
Aleksandra Petrović Fabijan, Jonathan R. Iredell, Katarzyna Danis‐Wlodarczyk

et al.

PLoS Biology, Journal Year: 2023, Volume and Issue: 21(5), P. e3002119 - e3002119

Published: May 23, 2023

Phage therapy is a medical form of biological control bacterial infections, one that uses naturally occurring viruses, called bacteriophages or phages, as antibacterial agents. Pioneered over 100 years ago, phage nonetheless currently experiencing resurgence in interest, with growing numbers clinical case studies being published. This renewed enthusiasm due large part to holding promise for providing safe and effective cures infections traditional antibiotics acting alone have been unable clear. Essay introduces basic biology, provides an outline the long history therapy, highlights some advantages using phages agents, overview recent successes. Although has clear potential, it faces biological, regulatory, economic challenges its further implementation more mainstream acceptance.

Language: Английский

Citations

66
Developing Phage Therapy That Overcomes the Evolution of Bacterial Resistance DOI Creative Commons

Agnès Oromí-Bosch,

Jyot D. Antani, Paul E. Turner

et al.

Annual Review of Virology, Journal Year: 2023, Volume and Issue: 10(1), P. 503 - 524

Published: June 2, 2023

The global rise of antibiotic resistance in bacterial pathogens and the waning efficacy antibiotics urge consideration alternative antimicrobial strategies. Phage therapy is a classic approach where bacteriophages (bacteria-specific viruses) are used against infections, with many recent successes personalized medicine treatment intractable infections. However, perpetual challenge for developing generalized phage expectation that viruses will exert selection target bacteria to deploy defenses virus attack, causing evolution during patient treatment. Here we review two main complementary strategies mitigating therapy: minimizing ability populations evolve driving (steering) phage-resistant toward clinically favorable outcomes. We discuss future research directions might further address phage-resistance problem, foster widespread development deployment therapeutic outsmart evolved clinical settings.

Language: Английский

Citations

62
Expanding antibiotic, vaccine, and diagnostics development and access to tackle antimicrobial resistance DOI
Ramanan Laxminarayan, Isabella Impalli, Radha Rangarajan

et al.

The Lancet, Journal Year: 2024, Volume and Issue: 403(10443), P. 2534 - 2550

Published: May 23, 2024

Language: Английский

Citations

47
An effective antibiofilm strategy based on bacteriophages armed with silver nanoparticles DOI Creative Commons
Mateusz Szymczak, Jarosław A. Pankowski, Agnieszka Kwiatek

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: April 20, 2024

Abstract The emerging antibiotic resistance in pathogenic bacteria is a key problem modern medicine that has led to search for novel therapeutic strategies. A potential approach managing such involves the use of their natural killers, namely lytic bacteriophages. Another effective method metal nanoparticles with antimicrobial properties. However, phages armed as an strategy, particularly respect biofilms, remains unexplored. Here, we show T7 silver exhibit greater efficacy terms controlling bacterial biofilm, compared or alone. We initially identified nanoparticle-binding peptide, then constructed successfully displayed peptide on outer surface viral head. These recombinant, AgNP-binding could effectively eradicate even when used at low concentrations. Additionally, concentrations were not toxic eukaryotic cells. Our results combination phage-bound effective, synergistic and safe strategy treatment biofilms.

Language: Английский

Citations

18
Engineering therapeutic phages for enhanced antibacterial efficacy DOI Creative Commons
Susanne Meile, Jiemin Du, Matthew Dunne

et al.

Current Opinion in Virology, Journal Year: 2021, Volume and Issue: 52, P. 182 - 191

Published: Dec. 21, 2021

The alarming rise in antimicrobial resistance coupled with a lack of innovation antibiotics has renewed interest the development alternative therapies to combat bacterial infections. Despite phage therapy demonstrating success various individual cases, comprehensive and unequivocal demonstration therapeutic potential phages remains be shown. co-evolution their hosts resulted several inherent limitations for use natural as therapeutics such restricted host range, moderate antibacterial efficacy, frequent emergence phage-resistance. However, these constraints can overcome by leveraging recent advances synthetic biology genetic engineering provide additional capabilities, improved safety profiles, adaptable ranges. Here, we examine different ways engineered deliver heterologous payloads enhance efficacy discuss versatile applicability pathogens.

Language: Английский

Citations

64