The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 908, P. 168461 - 168461
Published: Nov. 13, 2023
Language: Английский
Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(12), P. 1638 - 1638
Published: Nov. 22, 2023
The increasing drug resistance of bacteria to commonly used antibiotics creates the need search for and develop alternative forms treatment. Phage therapy fits this trend perfectly. Phages that selectively infect kill are often only life-saving therapeutic option. Full legalization treatment method could help solve problem multidrug-resistant infectious diseases on a global scale. aim review is present prospects development phage therapy, ethical legal aspects form given current situation such benefits using products in persons whom available options have been exhausted or do not exist at all. In addition, challenges faced by fight against bacterial infections also described. More clinical studies needed expand knowledge about phages, their dosage, standardized delivery system. These activities necessary ensure phage-based does take an experiment but standard medical Bacterial viruses will probably become miracle cure—a panacea infections—but they chance find important place medicine.
Language: Английский
Citations
65
Microorganisms, Journal Year: 2023, Volume and Issue: 11(9), P. 2169 - 2169
Published: Aug. 28, 2023
Urinary tract infections (UTIs) are among the most common bacterial infections, especially women and older adults, leading to a significant global healthcare cost burden. Uropathogenic
Language: Английский
Citations
61
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: April 6, 2024
Abstract Bacteriophage therapy is a promising approach to address antimicrobial infections though questions remain regarding the impact of immune response on clinical effectiveness. Here, we develop mouse model assess phage treatment using cocktail five phages from Myoviridae and Siphoviridae families that target Vancomycin-Resistant Enterococcus gut colonization. Phage significantly reduces fecal bacterial loads Enterococcus. We also characterize responses elicited following administration cocktail. While minimal innate are observed after administration, two rounds induces phage-specific neutralizing antibodies accelerate clearance tissues. Interestingly, myophages in our induce more robust antibody than siphophages. This anti-phage immunity effectiveness murine model. Collectively, this study shows may be an important consideration development cocktails for therapeutic use.
Language: Английский
Citations
25
Microorganisms, Journal Year: 2024, Volume and Issue: 12(9), P. 1920 - 1920
Published: Sept. 21, 2024
Antimicrobial resistance (AMR), frequently considered a major global public health threat, requires comprehensive understanding of its emergence, mechanisms, advances, and implications. AMR’s epidemiological landscape is characterized by widespread prevalence constantly evolving patterns, with multidrug-resistant organisms (MDROs) creating new challenges every day. The most common mechanisms underlying AMR (i.e., genetic mutations, horizontal gene transfer, selective pressure) contribute to the emergence dissemination resistant strains. Therefore, mitigation strategies (e.g., antibiotic stewardship programs—ASPs—and infection prevention control strategies—IPCs) emphasize importance responsible antimicrobial use surveillance. A One Health approach interconnectedness human, animal, environmental health) highlights necessity for interdisciplinary collaboration holistic in combating AMR. Advancements novel therapeutics alternative agents vaccines) offer promising avenues addressing challenges. Policy interventions at international national levels also promote ASPs aiming regulate use. Despite all observed progress, remains pressing concern, demanding sustained efforts address emerging threats sustainability. Future research must prioritize innovative approaches complex socioecological dynamics This manuscript resource researchers, policymakers, healthcare professionals seeking navigate develop effective mitigation.
Language: Английский
Citations
22
Viruses, Journal Year: 2024, Volume and Issue: 16(3), P. 443 - 443
Published: March 12, 2024
Bacteriophage therapy is a promising approach to treating bacterial infections. Research and development of bacteriophage intensifying due the increase in antibiotic resistance faltering new antibiotics. uses bacteriophages (phages), i.e., prokaryotic viruses, specifically target kill pathogenic bacteria. The legal handling this type raises several questions. These include whether phage therapeutics belong specially regulated class medicinal products, which framework should be followed with regard various technical ways can manufactured administered. article shows products from wild phages genetically modified (designer) do or not belong. Furthermore, explains relevant for manufacture administration therapeutics, are advance uniform, patient-independent manner, tailor-made patient-specific therapeutics. For systematically coherent, successful translation therapy, considers pharmaceutical law related areas, such as genetic engineering law. Finally, how planned legislative revisions Directive 2001/83/EC Regulation (EC) No 726/2004 may affect future therapy.
Language: Английский
Citations
19
Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: Sept. 26, 2024
Inflammatory periodontal diseases associated with the accumulation of dental biofilm, such as gingivitis and periodontitis, are very common pose clinical problems for clinicians patients. Gingivitis is a mild form gum disease when treated quickly properly completely reversible. Periodontitis an advanced irreversible periodontium periods exacerbations, progressions remission. chronic inflammatory condition that damages tissues supporting tooth in its socket, i.e., gums, ligaments, root cementum bone. Periodontal inflammation most commonly triggered by bacteria present excessive accumulations plaque (biofilm) on surfaces. This driven disproportionate host immune responses induced imbalance composition oral changes their metabolic activities. microbial dysbiosis favors establishment conditions ultimately results destruction tooth-supporting tissues. Apart shift response, environmental factors genetics also important etiology In addition to destruction, can result significant systemic complications. Conventional methods treatment (improving hygiene, biofilm control, mechanical removal, using local or antimicrobial agents) not fully effective. All this prompts search new therapy. Advanced periodontitis multiple abscesses often antibiotics, amoxicillin, tetracycline, doxycycline, minocycline, clindamycin, combined therapy amoxicillin metronidazole. However, due growing problem antibiotic resistance, does always achieve desired therapeutic effect. review summarizes pathogenesis, current approaches treatment, limitations state research possibility application bacteriophages predatory combat responsible periodontitis. We landscape potential applications alternative therapies based phages bacteria, highlight gaps existing knowledge need be addressed before trials utilizing these strategies seriously considered.
Language: Английский
Citations
16
PharmaNutrition, Journal Year: 2025, Volume and Issue: unknown, P. 100435 - 100435
Published: Feb. 1, 2025
Language: Английский
Citations
2
Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(10), P. 1467 - 1467
Published: Oct. 16, 2023
The rapid emergence of multidrug-resistant (MDR) bacteria in recent times has prompted the search for new and more potent antibiotics. Bacteriophages (commonly known as phages) are viruses that target infect their bacterial hosts. As such, they also a potential alternative to These phages can be broadly categorized into monovalent (with narrow host range spectrum specific single genus) polyvalent broad than two genera). However, there is still much ambiguity use these terms, with researchers often describing differently. There considerable research on both narrow- broad-host treatment infections diseases caused by MDR bacteria, including tuberculosis, cystic fibrosis, carbapenem-resistant Enterobacterales (CRE) infectious diseases. From this, it clear plays vital role determining effectiveness any phage therapy, this factor usually analyzed based advantages limitations different ranges. have been efforts expand ranges via cocktail development, engineering combination therapies, line current technological advancements. This literature review aims provide in-depth understanding treating MDR-bacterial diseases, exploring following: biology, importance treatment, its limitations, findings developments, finally, possible future directions wide phages.
Language: Английский
Citations
23
Cell, Journal Year: 2024, Volume and Issue: 187(19), P. 5195 - 5216
Published: Sept. 1, 2024
Language: Английский
Citations
15
Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: July 5, 2024
Amid the growing challenge of antibiotic resistance on a global scale, there has been notable resurgence in bacteriophage-based treatments, signaling shift our approach to managing infections. Bacteriophages (BPs), bacterial predators nature, present promising alternative for tackling infections caused by antibiotic-resistant pathogens. This review delves into intricate relationship between bacteriophages and resistant bacteria, exploring various treatment strategies. Drawing upon both preclinical clinical studies, highlights effectiveness bacteriophage therapy, particularly when integrated synergistically with conventional antibiotics. It discusses approaches systemic localized infections, demonstrating adaptability therapy across different scenarios. Furthermore, formulation delivery shed light methods used encapsulate administer them effectively. also acknowledges ongoing efforts overcome this hurdle. In addition, importance sensitivity profile (phagogram), which helps tailor regimens individual patients specific By surpassing limitations traditional antibiotics, therapies offer personalized potent solution against resistance, reshape future infectious disease management.
Language: Английский
Citations
11