Viruses,
Journal Year:
2023,
Volume and Issue:
15(2), P. 537 - 537
Published: Feb. 14, 2023
Influenza
infection
is
a
cause
of
exacerbations
in
patients
with
chronic
pulmonary
diseases.
The
aim
this
study
was
to
investigate
the
clinical
outcomes
and
identify
risk
factors
associated
hospitalization
mortality
following
influenza
adult
bronchiectasis.
Using
Chang
Gung
Research
Database,
we
identified
bronchiectasis
influenza-related
(ICD-9-CM
487
anti-viral
medicine)
between
2008
2017.
main
were
in-hospital
rate.
Eight
hundred
sixty-five
identified.
Five
thirty-six
(62%)
hospitalized
for
118
(22%)
had
respiratory
failure.
Compared
group
only
seen
clinic,
older,
more
male
patients,
lower
FEV1,
higher
aetiology
comorbidity
index
(BACI),
acute
previous
year.
Co-infections
evident
55.6%
mainly
caused
by
Pseudomonas
aeruginosa
(15%),
fungus
(7%),
Klebsiella
pneumoniae
(6%).
failure
developed
kidney
injury
(36%
vs.
16%;
p
<
0.001),
shock
(47%
6%;
0.001)
often
than
without
overall
rate
10.8%
exhibited
significantly
rates
(27.1%
6.2%;
0.001).
Age,
BACI,
independently
hospitalization.
presence
shock,
low
platelet
counts
increased
hospital
mortality.
virus
severe
exacerbation
bronchiectasis,
especially
those
who
older
high
BACI
scores
exacerbations.
A
observed
We
highlight
importance
preventing
or
treating
RSC Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
15(5), P. 1589 - 1600
Published: Jan. 1, 2024
Is
magic
trifluoromethyl
a
thing?
Replacing
4-CH
3
with
4-CF
in
bithiazoles,
allowed
to
identify
broad
antimicrobial
agents
active
against
multiple
viruses
and
also
Gram-positive/negative
bacteria.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(4), P. 761 - 761
Published: March 29, 2024
Community-acquired
pneumonia
is
reported
as
one
of
the
infectious
diseases
that
leads
to
development
acute
respiratory
distress
syndrome.
The
innate
immune
system
first
line
defence
against
microbial
invasion;
however,
its
dysregulation
during
infection,
resulting
in
an
increased
pathogen
load,
stimulates
over-secretion
chemokines
and
pro-inflammatory
cytokines.
This
phenomenon
causes
damage
epithelial–endothelial
barrier
pulmonary
alveoli
leakage
intravascular
protein
into
alveolar
lumen.
Fluoroquinolones
are
synthetic
antimicrobial
agents
with
immunomodulatory
properties
can
inhibit
bacterial
proliferation
well
exhibit
anti-inflammatory
activities.
It
has
been
demonstrated
structure
fluoroquinolones,
particularly
those
a
cyclopropyl
group,
exerts
effects.
Its
capability
phosphodiesterase
activity
accumulation
intracellular
cAMP,
which
subsequently
enhances
PKA
activity,
inhibition
transcriptional
factor
NF-κB
activation
CREB.
Another
mechanism
TLR
ERK
signalling
pathways.
Although
sequence
events
not
completely
understood,
significant
progress
made
comprehending
specific
mechanisms
underlying
effects
fluoroquinolones.
Here,
we
review
indirect
FQs
alternative
empirical
therapy
patients
diagnosed
community-acquired
pneumonia.
Journal of Applied Microbiology,
Journal Year:
2024,
Volume and Issue:
135(6)
Published: June 1, 2024
Understanding
disease
pathogenesis
caused
by
bacteria/virus,
from
the
perspective
of
individual
pathogen
has
provided
meaningful
insights.
However,
as
viral
and
bacterial
counterparts
might
inhabit
same
infection
site,
it
becomes
crucial
to
consider
their
interactions
contributions
in
onset
progression.
The
objective
review
is
highlight
importance
considering
both
agents
during
course
coinfection.
provides
a
unique
on
general
theme
virus-bacteria
interactions,
which
either
lead
colocalized
infections
that
are
restricted
one
anatomical
niche,
or
systemic
have
effect
human
host.
sequence,
nature,
underlying
mechanisms
certain
been
elaborated
with
relevant
examples
literature.
It
also
attempts
address
various
applied
aspects,
including
diagnostic
therapeutic
strategies
for
well
coinfections.
aims
aid
researchers
comprehending
intricate
interplay
between
virus
bacteria
progression,
thereby
enhancing
understanding
current
methodologies
empowering
development
novel
health
care
tackle
Viruses,
Journal Year:
2023,
Volume and Issue:
15(2), P. 537 - 537
Published: Feb. 14, 2023
Influenza
infection
is
a
cause
of
exacerbations
in
patients
with
chronic
pulmonary
diseases.
The
aim
this
study
was
to
investigate
the
clinical
outcomes
and
identify
risk
factors
associated
hospitalization
mortality
following
influenza
adult
bronchiectasis.
Using
Chang
Gung
Research
Database,
we
identified
bronchiectasis
influenza-related
(ICD-9-CM
487
anti-viral
medicine)
between
2008
2017.
main
were
in-hospital
rate.
Eight
hundred
sixty-five
identified.
Five
thirty-six
(62%)
hospitalized
for
118
(22%)
had
respiratory
failure.
Compared
group
only
seen
clinic,
older,
more
male
patients,
lower
FEV1,
higher
aetiology
comorbidity
index
(BACI),
acute
previous
year.
Co-infections
evident
55.6%
mainly
caused
by
Pseudomonas
aeruginosa
(15%),
fungus
(7%),
Klebsiella
pneumoniae
(6%).
failure
developed
kidney
injury
(36%
vs.
16%;
p
<
0.001),
shock
(47%
6%;
0.001)
often
than
without
overall
rate
10.8%
exhibited
significantly
rates
(27.1%
6.2%;
0.001).
Age,
BACI,
independently
hospitalization.
presence
shock,
low
platelet
counts
increased
hospital
mortality.
virus
severe
exacerbation
bronchiectasis,
especially
those
who
older
high
BACI
scores
exacerbations.
A
observed
We
highlight
importance
preventing
or
treating
