Possible Spreading of SARS-CoV-2 from Humans to Captive Non-Human Primates in the Peruvian Amazon DOI Creative Commons
A. Gonzales, Jhonathan Bazalar-Gonzales, Thalía Silvestre Espejo

et al.

Animals, Journal Year: 2024, Volume and Issue: 14(5), P. 732 - 732

Published: Feb. 27, 2024

Human-to-animal transmission events of SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) have been reported in both domestic and wild species worldwide. Despite the high rates contagion mortality during COVID-19 (Coronavirus Diseases 2019) pandemic Peru, no instances natural virus infection documented animals, particularly Amazonian regions where human–wildlife interactions are prevalent. In this study, we conducted a surveillance investigation using viral RNA sequencing fecal samples collected from 76 captive semi-captive non-human primates (NHPs) Loreto, Ucayali, Madre de Dios between August 2022 February 2023. We detected segment RNA-dependent polymerase (RdRp) gene by metagenomic pooled sample white-fronted capuchins (Cebus unicolor) at rescue center Bello Horizonte, Ucayali. Phylogenetic analysis further confirmed that retrieved partial sequence RdRp matched genome. This study represents first instance molecular detection NHPs Peruvian Amazon, underscoring adverse impact anthropic activities on human–NHP interface emphasizing importance ongoing for early prediction future emergence new variants animals.

Language: Английский

Multiple spillovers from humans and onward transmission of SARS-CoV-2 in white-tailed deer DOI Creative Commons
Suresh V. Kuchipudi, Meera Surendran Nair, Rachel M. Ruden

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(6)

Published: Jan. 25, 2022

Significance The results provide strong evidence of extensive SARS-CoV-2 infection white-tailed deer, a free-living wild animal species with widespread distribution across North, Central, and South America. analysis shows deer resulted from multiple spillovers humans, followed by efficient deer-to-deer transmission. discovery indicates their establishment as potential reservoir hosts for SARS-CoV-2, finding important implications the ecology, long-term persistence, evolution virus, including spillback to humans.

Language: Английский

Citations

211
Transmission of SARS-CoV-2 in free-ranging white-tailed deer in the United States DOI Creative Commons
Aijing Feng, Sarah N. Bevins,

Jeff Chandler

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: July 10, 2023

Abstract SARS-CoV-2 is a zoonotic virus with documented bi-directional transmission between people and animals. Transmission of from humans to free-ranging white-tailed deer ( Odocoileus virginianus ) poses unique public health risk due the potential for reservoir establishment where variants may persist evolve. We collected 8,830 respiratory samples across Washington, D.C. 26 states in United States November 2021 April 2022. obtained 391 sequences identified 34 Pango lineages including Alpha, Gamma, Delta, Omicron variants. Evolutionary analyses showed these viruses originated at least 109 independent spillovers humans, which resulted 39 cases subsequent local deer-to-deer three spillover back humans. Viruses repeatedly adapted recurring amino acid substitutions spike other proteins. Overall, our findings suggest that multiple were introduced, became enzootic, co-circulated deer.

Language: Английский

Citations

51
Animal Models, Zoonotic Reservoirs, and Cross-Species Transmission of Emerging Human-Infecting Coronaviruses DOI Creative Commons
Yakhouba Kane,

Gary Wong,

George F. Gao

et al.

Annual Review of Animal Biosciences, Journal Year: 2023, Volume and Issue: 11(1), P. 1 - 31

Published: Feb. 15, 2023

Over the past three decades, coronavirus (CoV) diseases have impacted humans more than any other emerging infectious disease. The recent emergence of severe acute respiratory syndrome 2 (SARS-CoV-2), causative agent COVID-19 (coronavirus disease 2019), has resulted in huge economic disruptions and loss human lives. SARS-CoV-2 genome was found to mutate rapidly due sustained transmission potentially animals, resulting variants concern (VOCs) that threaten global health. However, primary difficulties are filling current knowledge gaps terms origin modalities for these viruses. Because many CoVs threatening health suspected a zoonotic origin, identifying animal hosts implicated spillover or spillback events would be beneficial pandemic management prevent future outbreaks. In this review, wesummarize models, reservoirs, cross-species CoVs. Finally, we comment on potential sources Omicron VOCs new recombinants currently under investigation.

Language: Английский

Citations

24
Widespread exposure to SARS-CoV-2 in wildlife communities DOI Creative Commons
Amanda R. Goldberg, Kate E. Langwig, Katherine L. Brown

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 29, 2024

Pervasive SARS-CoV-2 infections in humans have led to multiple transmission events animals. While has a potential broad wildlife host range, most documented been captive animals and single species, the white-tailed deer. The full extent of exposure among communities factors that influence risk remain unknown. We sampled 23 species for examined effects urbanization human use on seropositivity. Here, we document positive detections RNA six including deer mouse, Virginia opossum, raccoon, groundhog, Eastern cottontail, red bat between May 2022-September 2023 across Washington, D.C., USA. In addition, found sites with high activity had three times higher seroprevalence than low human-use areas. obtained genomic sequences from nine individuals which were assigned seven Pango lineages Omicron variant. close match variants circulating at time suggests least recent human-to-animal events. Our data support widespread areas may serve as points contact cross-species transmission.

Language: Английский

Citations

17
Evolution of SARS-CoV-2 in white-tailed deer in Pennsylvania 2021–2024 DOI Creative Commons
Andrew D. Marques,

Matthew Hogenauer,

Natalie Bauer

et al.

PLoS Pathogens, Journal Year: 2025, Volume and Issue: 21(1), P. e1012883 - e1012883

Published: Jan. 24, 2025

SARS-CoV-2 continues to transmit and evolve in humans animals. White-tailed deer ( Odocoileus virginianus ) have been previously identified as a zoonotic reservoir for with high rates of infection probable spillback into humans. Here we report sampling 1,127 white-tailed (WTD) Pennsylvania, genomic analysis viral dynamics spanning 1,017 days between April 2021 January 2024. To assess load genotypes, RNA was isolated from retropharyngeal lymph nodes analyzed using RT-qPCR whole genome sequencing. Samples showed 14.64% positivity rate by RT-qPCR. Analysis no association prevalence age, sex, or diagnosis Chronic Wasting Disease. From the 165 positive WTD, recovered 25 sequences an additional 17 spike-targeted amplicon sequences. The variants included Alpha, 11 Delta, 14 Omicron. Alpha largely stopped circulating around September 2021, but persisted WTD recently March 2023. Phylodynamic pooled data Pennsylvania documents at least 12 spillovers including recent series Omicron spillovers. Prevalence higher regions crop coverage rather than forest, suggesting proximity seasonality increased winter spring. Multiple examples recurrent mutations were associated transmissions, WTD-specific evolutionary pressures. These document ongoing infections deer, onward transmission remarkable new

Language: Английский

Citations

1
Detection of SARS-CoV-2 Omicron variant (B.1.1.529) infection of white-tailed deer DOI Creative Commons
Kurt J. Vandegrift,

Michele Yon,

Meera Surendran Nair

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: Feb. 7, 2022

White-tailed deer (

Language: Английский

Citations

32
Susceptibility of sheep to experimental co-infection with the ancestral lineage of SARS-CoV-2 and its alpha variant DOI Creative Commons
Natasha N. Gaudreault, Konner Cool, Jessie D. Trujillo

et al.

Emerging Microbes & Infections, Journal Year: 2022, Volume and Issue: 11(1), P. 662 - 675

Published: Feb. 2, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for a global pandemic that has had significant impacts on human health and economies worldwide. SARS-CoV-2 highly transmissible the cause of disease 2019 in humans. A wide range animal species have also been shown to be susceptible by experimental and/or natural infections. Sheep are commonly farmed domestic ruminant not thoroughly investigated their susceptibility SARS-CoV-2. Therefore, we performed vitro vivo studies which consisted infection ruminant-derived cells challenge sheep investigate Our results showed sheep-derived kidney support replication. Furthermore, demonstrated limited with viral RNA shed nasal oral swabs at 1 3-days post (DPC); was detected tract lymphoid tissues 4 8 DPC. Sero-reactivity observed some principal infected but contact sentinels, indicating transmission co-mingled naïve efficient; however, sentinel animals 21 used inoculum consisting mixture two isolates, representatives ancestral lineage B.1.1.7-like alpha variant concern, study competition virus strains. indicate show low outcompeted strain.

Language: Английский

Citations

31
SARS‐CoV‐2 and natural infection in animals DOI

Xinyu Qiu,

Yi Liu, Ailong Sha

et al.

Journal of Medical Virology, Journal Year: 2022, Volume and Issue: 95(1)

Published: Sept. 19, 2022

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of novel coronavirus disease (COVID-19) pandemic, which has caused serious challenges for public health systems worldwide. Due to close relationship between animals and humans, confirmed transmission from humans numerous animal species been reported. Understanding cross-species SARS-CoV-2 infection dynamics in different crucial control COVID-19 protect health. In this review, possible origins naturally susceptible are discussed. Furthermore, review categorizes by families, so as better understand animals.

Language: Английский

Citations

31
SARS-CoV-2 Omicron (B.1.1.529) Infection of Wild White-Tailed Deer in New York City DOI Creative Commons
Kurt J. Vandegrift,

Michele Yon,

Meera Surendran Nair

et al.

Viruses, Journal Year: 2022, Volume and Issue: 14(12), P. 2770 - 2770

Published: Dec. 12, 2022

There is mounting evidence of SARS-CoV-2 spillover from humans into many domestic, companion, and wild animal species. Research indicates that have infected white-tailed deer, deer-to-deer transmission has occurred, indicating deer could be a wildlife reservoir source novel variants. We examined the hypothesis Omicron variant actively asymptomatically infecting free-ranging New York City. Between December 2021 February 2022, 155 on Staten Island, York, were anesthetized for gross abnormalities illnesses. Paired nasopharyngeal swabs blood samples collected analyzed presence RNA antibodies. Of 135 serum samples, 19 (14.1%) indicated exposure, 11 reacted most strongly to wild-type B.1 lineage. 71 swabs, 8 positive (4 4 Delta). Two animals had active infections robust neutralizing antibodies, revealing reinfection or early seroconversion in deer. Variants concern continue circulate among may reinfect US populations, establish enzootic cycles wild: this warrants coordinated One Health response, proactively surveil, identify, curtail variants before they can spill back humans.

Language: Английский

Citations

31
Olfactory immune response to SARS-CoV-2 DOI Creative Commons
Sebastian A. Wellford, E. Ashley Moseman

Cellular and Molecular Immunology, Journal Year: 2023, Volume and Issue: 21(2), P. 134 - 143

Published: Dec. 25, 2023

Abstract Numerous pathogens can infect the olfactory tract, yet pandemic caused by SARS-CoV-2 has strongly emphasized importance of mucosa as an immune barrier. Situated in nasal passages, is directly exposed to environment sense airborne odorants; however, this also means it serve a direct route entry from outside world into brain. As result, olfactotropic infections have serious consequences, including dysfunction system, CNS invasion, dissemination lower respiratory and transmission between individuals. Recent research shown that distinctive response needed protect neuronal mucosal tissue. A better understanding innate, adaptive, structural barriers develop effective therapeutics vaccines against microbes such SARS-CoV-2. Here, we summarize ramifications infection mucosa, review subsequent response, discuss important areas future for immunity infectious disease.

Language: Английский

Citations

16