The Role of Interventional Radiology and Management of an Angiography Suite in the Treatment of COVID-19 Patients: Single-Center, 2-Year Experience DOI Creative Commons
Jong Joon Shim, Jae Myeong Lee

Medicina, Journal Year: 2023, Volume and Issue: 59(2), P. 188 - 188

Published: Jan. 17, 2023

Background and Objectives: Hospital angiography suites with negative-pressure ventilation facilities are challenging to equip. During the COVID-19 pandemic, we aimed introduce interventional radiology procedures performed on patients understand management of suite without a facility before after prevent spread infection. Materials Methods: Between December 2020 November 2022, 52 underwent in an suite, where no was installed. procedure, all staff members wore full personal protection equipment, procedure for COVID-19-positive patient completed, disinfected entry prohibited 1-3 h. In this non-COVID-19 were performed. Results: A total 61 COVID-19. Of patients, 21 under intubation mechanical ventilation. All according guidelines set by Infection Control Committee our hospital. No major or minor complications associated procedures. There cases infection among other related patients. Conclusions: Interventional can play important role solving problems caused patients' underlying diseases. addition, if accurate followed, both undergo room while preventing

Language: Английский

Emerging infectious diseases, focus on infection prevention, environmental survival and germicide susceptibility: SARS-CoV-2, Mpox, and Candida auris DOI Open Access
David J. Weber, William A. Rutala,

Emily Sickbert-Bennett

et al.

American Journal of Infection Control, Journal Year: 2023, Volume and Issue: 51(11), P. A22 - A34

Published: Oct. 25, 2023

Language: Английский

Citations

10
Enhanced biocidal efficacy of alcohol based disinfectants with salt additives DOI Creative Commons

Euna Oh,

Hyerin Shin, Sumin Han

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 31, 2025

Language: Английский

Citations

0
Antiviral Activity of Halogenated Compounds Derived from L-Tyrosine Against SARS-CoV-2 DOI Creative Commons

Paula A. Velásquez-Bedoya,

María I. Zapata-Cardona, Laura Milena Monsalve-Escudero

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(7), P. 1419 - 1419

Published: March 22, 2025

Introduction: Currently, there are no effective medications for treating all the clinical conditions of patients with COVID-19. We aimed to evaluate antiviral activity compounds derived from L-tyrosine against B.1 lineage SARS-CoV-2 in vitro and silico. Methodology: The cytotoxicities 15 halogenated were evaluated Vero-E6 cells by MTT assay. was using four strategies, viral quantification performed a plaque assay qRT-PCR. toxicity ADMET predictor software. affinity these or cellular proteins stability their conformations determined docking molecular dynamics, respectively. Results: TODC-3M, TODI-2M, YODC-3M reduced titer >40% inhibited replication RNA without significant cytotoxicity. In silico analyses revealed that presented low binding energies between −4.3 −5.2 Kcal/mol three (spike, Mpro, RdRp). TODC-3M most stable proteins. Conclusions: promising YODC-3M, which toxicity, potential through different favorable affinities targets. Therefore, they candidates vivo studies.

Language: Английский

Citations

0
Application of a Non-targeted Biomonitoring Method to Characterize Occupational Chemical Exposures of Women Nurses Relative to Office Workers DOI Creative Commons
Kristin Knox, Dimitri Abrahamsson, Jessica Trowbridge

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

We analyzed blood serum samples from two unique female occupational cohorts - 60 nurses and 40 office workers in San Francisco, CA using liquid chromatography high-resolution mass spectrometry (quadrupole time-of-flight). Applying a nontargeted analysis (NTA) approach, we sought to isolate occupationally related chemical exposures that were by flagging features different abundance (mean; 95th percentile) or detection frequency. Of 9828 negative electrospray ionization (ESI-) 6898 positive (ESI+) detected features, 1094 938, respectively, higher nurses, possibly due workplace exposures. deciphered the molecular structures of these applying data-dependent acquisition (DDA) targeted MS/MS approaches pooled each group, annotated them spectral databases MS-DIAL. Nurses had concentrations 14 chemicals identified at Schymanski Level 1 (N = 6) 2 8), as well 20 tentatively without spectra. Several may be relevant for including PFAS (6:2 fluorotelomer sulfonic acid), tridecanedioic acid, salicylic medications acetaminophen theophylline. To our knowledge, this study is first apply NTA elucidate novel nurses.

Language: Английский

Citations

0
Virucidal efficacy of hypochlorous acid water for aqueous phase and atomization against SARS-CoV-2 DOI Creative Commons
Makoto Kubo, Ryotaro Eda, Shotaro Maehana

et al.

Journal of Water and Health, Journal Year: 2024, Volume and Issue: 22(3), P. 601 - 611

Published: Feb. 14, 2024

Abstract Coronavirus disease 2019 (COVID-19) is an infectious viral caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerged at the end of 2019. SARS-CoV-2 can be transmitted through droplets, aerosols, and fomites. Disinfectants such as alcohol, quaternary ammonium salts, chlorine-releasing agents, including hypochlorous acid, are used to prevent spread infection. In present study, we investigated efficacy ionless acid water (HOCl) in suspension spraying inactivate SARS-CoV-2. The virucidal HOCl solution tests against was evaluated 50% tissue culture dose. Although presence organic compounds influenced efficacy, treatment for 20 s significantly effective Wuhan Delta strains test. atomization several hours reduced attached plastic plates. These results indicate with elimination containing NaCl other ions may have high This study provides important information about use solution.

Language: Английский

Citations

2
Chemical stability of active ingredients in diluted veterinary disinfectant solutions under simulated storage conditions DOI Creative Commons
Chae Hong Rhee, Hye‐Sook Lee,

H. M. Yun

et al.

Frontiers in Chemistry, Journal Year: 2023, Volume and Issue: 11

Published: June 16, 2023

Introduction: The product labels of veterinary disinfectants specify their expiration dates to prevent the use outdated products, as these may result in disinfection and biosecurity failures during outbreak situations. However, a clear standard for storage conditions diluted disinfectant solutions has not yet been established, effects have scarcely investigated. To fill this research gap, our study examined stability active ingredients based on change concentrations when stored at various temperatures time periods. Methods: Twenty effective against either foot-and-mouth disease or avian influenza viruses were selected. following manufacturer’s instructions. Using selective analytical techniques, samples that had varying intervals different (4, 20, 30, 45°C) determined. These included soaps detergents, acids, oxidizing agents, aldehydes, copper compounds. ingredient two determined freezing/thawing cycle, establish exposed simulated winter conditions. Results: Our results showed most 90% greater initial concentrations, indicating ≥90% over 21-day period under experimental there some exceptions. Glutaraldehyde, formaldehyde, malic acid are stable ≤ 30°C 21 days, but decreased below 45°C, decline 45°C days. potassium peroxymonosulfate peracetic rapidly declined with increasing temperature less than concentrations. Discussion: Based findings, we propose should preferably be prepared daily. if daily preparation solution is feasible, then can used reference, providing basic scientific data chemical commonly field, thus suitable

Language: Английский

Citations

6
The Effect of Water Hardness and pH on the Efficacy of Peracetic Acid and Sodium Hypochlorite against SARS-CoV-2 on Food-Contact Surfaces DOI Creative Commons

Julianna N. Morris,

Malak A. Esseili

Foods, Journal Year: 2023, Volume and Issue: 12(16), P. 2981 - 2981

Published: Aug. 8, 2023

Sodium hypochlorite (NaOCl) and peracetic acid (PAA) are commonly used disinfectants with a maximum recommended concentration of 200 ppm for food-contact surfaces. The objectives this study were to assess the effect pH water hardness on NaOCl PAA efficacy against SARS-CoV-2 stainless steel (SS). two prepared at in 150 or 300 final adjusted 5, 6, 7, 8. Disinfectants applied virus-contaminated SS one minute room temperature following ASTM E2197 standard assay. infectivity was quantified using TCID50 assay Vero-E6 cells. In general, increasingly hard decreased while increasing PAA. Hard significantly increased virus log reduction 8 by ~1.5 log. reductions observed 5 both (~1.2 log) (~2 water, respectively. conclusion, performed better than harder water. However, not effective (≤3 contaminated surfaces, which may facilitate role these surfaces transmission.

Language: Английский

Citations

5
Propylene glycol inactivates respiratory viruses and prevents airborne transmission DOI Creative Commons
Christine T. Styles, Jie Zhou, Katie E. Flight

et al.

EMBO Molecular Medicine, Journal Year: 2023, Volume and Issue: 15(12)

Published: Nov. 16, 2023

Abstract Viruses are vulnerable as they transmit between hosts, and we aimed to exploit this critical window. We found that the ubiquitous, safe, inexpensive biodegradable small molecule propylene glycol (PG) has robust virucidal activity. Propylene rapidly inactivates a broad range of viruses including influenza A, SARS‐CoV‐2 rotavirus reduces disease burden in mice when administered intranasally at concentrations commonly nasal sprays. Most critically, vaporised PG efficiently abolishes A virus infectivity within airborne droplets, potently preventing infection levels well below those tolerated by mammals. present vapour first‐in‐class non‐toxic virucide can prevent transmission existing emergent viral pathogens, with clear immediate implications for public health.

Language: Английский

Citations

5
B-cell ELISpot assay to analyze human memory B cell and plasmablast responses specific to SARS-CoV-2 receptor-binding domain DOI Creative Commons
Angéline Rouers, Matthew Zirui Tay, Lisa F. P. Ng

et al.

STAR Protocols, Journal Year: 2023, Volume and Issue: 4(1), P. 102130 - 102130

Published: Feb. 9, 2023

B-cell ELISpot is an extremely sensitive assay based on the secretion of antibodies by B cells that requires differentiation into antibody-secreting cells. Here, we describe procedure to analyze both plasmablast (PB) and memory cell (MBC) responses specific SARS-CoV-2 receptor-binding domain (RBD) in context acute infection vaccination. We detail steps for MBC stimulation, PB plating, detection, counting total IgG RBD-specific spots. For complete details use execution this protocol, please refer Tay et al. (2022).1.

Language: Английский

Citations

3
The effectiveness of chlorine dioxide gas in portable personal disinfectants to inhibit bacterial growth DOI Creative Commons
Firdaus Ali,

Dwi Lintang Lestari,

Marsya Dyasthi Putri

et al.

Journal of Water and Health, Journal Year: 2023, Volume and Issue: 21(5), P. 537 - 546

Published: April 6, 2023

Disinfectants, especially air disinfectants, are necessary to prevent the potential spread of pathogens (bacteria and viruses) in pandemic era minimize pathogens. Some commercial disinfectant products that often used generally contain chlorine dioxide (ClO2) gas. This study tested effectiveness two different a liquid stick powder disinfection card, carry out pathogenic bacteria environment. These disinfectants were as medium for releasing gas which has much stronger bactericidal effect. In form stick, ClO2 is more effective process rather than powder. The inhibiting growth influenced by temperature area open space covered. Considering release from both very small (0.002 ppmv/h), it takes ensure runs effectively.

Language: Английский

Citations

3