2D-Bio-FETs for Sensitive Detection of Cardiovascular Diseases DOI

Piyush Choudhary,

Vijay K. Singh, Ambesh Dixit

et al.

Journal of Physics Condensed Matter, Journal Year: 2024, Volume and Issue: 36(41), P. 413004 - 413004

Published: July 18, 2024

Abstract The biosensing industry has seen exponential growth in the past decade. Impact of biosensors current scenario cannot be overlooked. Cardiovascular diseases (CvDs) have been recognized as one major causes for millions deaths globally. This mortality can minimized by early and accurate detection/diagnosis CvDs with help devices. also presents a global market opportunity development CvDs. A vast variety methods devices developed this problem. Most commercially available platforms CvD detection rely on optical (fluorometric colorimetric analysis) techniques using serum biomarkers since testing is gold standard medical diagnosis. Field effect transistors-based biosensors, termed Bio-FETs, are upcoming blood or analyte due to excellent sensitivity, low operational voltage, handheld device structure simple chip-based operation. Further, discovery two dimensional (2D) materials their integration conventional FETs improved overvoltage problem, sensitivity strict operating conditions compared FETs. Graphene-FETs based proven promising candidates attractive properties. Despite severe threat which further increased post-covid era, Bio-FET sensor studies literature still rare. In review, we aim provide comprehensive view all multidisciplinary concepts related 2D-BioFETs critical review different covered detailed discussions clear concept present status biosensors.

Language: Английский

DCRM 2.0: Multispecialty practice recommendations for the management of diabetes, cardiorenal, and metabolic diseases DOI Creative Commons
Yehuda Handelsman,

John E. Anderson,

George L. Bakris

et al.

Metabolism, Journal Year: 2024, Volume and Issue: 159, P. 155931 - 155931

Published: June 7, 2024

Language: Английский

Citations

20
Advances in heart failure monitoring: Biosensors targeting molecular markers in peripheral bio-fluids DOI
Tao Dong,

Wangang Zhu,

Zhaochu Yang

et al.

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 255, P. 116090 - 116090

Published: Feb. 5, 2024

Language: Английский

Citations

10
Animal Models for Studying Developmental Origins of Cardiovascular–Kidney–Metabolic Syndrome DOI Creative Commons
You‐Lin Tain, Ying-Jui Lin, Chien‐Ning Hsu

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 452 - 452

Published: Feb. 12, 2025

Cardiovascular-kidney-metabolic syndrome (CKMS) has become a significant global health challenge. Since CKMS often originates early in life, as outlined by the developmental origins of and disease (DOHaD) concept, prevention is more effective strategy than treatment. Various animal models, classified environmental exposures or mechanisms, are used to explore CKMS. However, no single model can fully replicate all aspects its clinical stages, limiting advancement preventive therapeutic strategies. This review aims assist researchers comparing strengths limitations common models programming studies highlighting key considerations for selecting suitable models.

Language: Английский

Citations

1
Examination of Cardiac Activity with ECG Monitoring Using Heart Rate Variability Methods DOI Creative Commons
Galya Georgieva-Tsaneva, Еvgeniya Gospodinova, Krasimir Cheshmedzhiev

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(9), P. 926 - 926

Published: April 29, 2024

The paper presents a system for analyzing cardiac activity with the possibility of continuous and remote monitoring. created sensor mobile device monitors heart by means convenient imperceptible registration signals. At same time, behavior human body is also monitored through accelerometer gyroscope built into device, thanks to which it possible signal in event loss consciousness or fall (in patients syncope). Conducting real-time cardio monitoring analysis recordings using various mathematical methods (linear, non-linear, graphical) enables research, accurate diagnosis, timely assistance, correct treatment cardiovascular diseases. examines diagnosed arrhythmia syncope recorded electrocardiography (ECG) sensors real conditions. obtained results are subjected statistical determine accuracy significance results. studies show significant deviations regarding values studied parameters rate variability (HRV) from accepted normal (for example, root mean square successive differences between heartbeats (RMSSD) healthy individuals 24.02 ms, while, (6.09 ms) (5.21 ms), much lower). quantitative graphic identify some abnormalities demonstrate disorders autonomic nervous system, directly related work heart.

Language: Английский

Citations

6
Pathogenic mechanisms of cardiovascular damage in COVID-19 DOI Creative Commons

Honghua Shao,

Rui‐Xing Yin

Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(1)

Published: June 19, 2024

Abstract Background COVID-19 is a new infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2). Since outbreak in December 2019, it has an unprecedented world pandemic, leading to global human health crisis. Although SARS CoV-2 mainly affects lungs, causing interstitial pneumonia and distress syndrome, number of patients often have extensive clinical manifestations, such as gastrointestinal symptoms, cardiovascular damage renal dysfunction. Purpose This review article discusses pathogenic mechanisms provides some useful suggestions for future diagnosis, treatment prevention. Methods An English-language literature search was conducted PubMed Web Science databases up 12th April, 2024 terms “COVID-19”, “SARS CoV-2”, “cardiovascular damage”, “myocardial injury”, “myocarditis”, “hypertension”, “arrhythmia”, “heart failure” “coronary heart disease”, especially update articles 2023 2024. Salient medical literatures regarding were selected, extracted synthesized. Results The most common myocarditis pericarditis, hypertension, arrhythmia, myocardial injury failure, coronary disease, stress cardiomyopathy, ischemic stroke, blood coagulation abnormalities, dyslipidemia. Two important may be direct viral cytotoxicity well indirect hyperimmune responses body infection. Conclusions Cardiovascular portends worse prognosis. underlying pathophysiological related are not completely clear, two SARSCoV-2 infection responses.

Language: Английский

Citations

5
Cardiac SARS-CoV-2 Infection, Involvement of Cytokines in Postmortem Immunohistochemical Study DOI Creative Commons
Letizia Alfieri, Lorenzo Franceschetti, Paolo Frisoni

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(8), P. 787 - 787

Published: April 9, 2024

In the context of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, significant attention was given to pulmonary manifestations. However, cardiac involvement is increasingly recognized as a critical factor influencing prognosis, leading myocardial damage, heart failure, coronary syndromes, potentially lethal arrhythmic events, and sudden death. Despite these findings, there lack studies detailing necroscopic, macroscopic, microscopic changes associated with SARS-CoV-2. This study aimed investigate presence SARS-CoV-2 viral proteins in tissue using immunohistochemical techniques assess tropism. The analysis samples from deceased subjects, different stages conservation, confirmed be positive for via reverse transcriptase-polymerase chain reaction (RT-PCR), showed immunopositivity SARS-CoV-2-NP antigen 33% cases. Notably, leukocyte infiltrates sufficient diagnosing lymphocytic myocarditis not observed. central proinflammatory cytokines involved pathogenetic mechanism disease 19 (COVID-19) were researched method. A increase cytokine expression detected, indicating dysfunction during infection. These findings suggest that detection antigens inflammatory could crucial proper forensic assessment cause death, even

Language: Английский

Citations

4
The impact of COVID-19 infection on thyroid function DOI Creative Commons

Esraah Alharris,

Dina Saleh,

Thair Wali Ali

et al.

Cellular and Molecular Biology, Journal Year: 2025, Volume and Issue: 70(12), P. 142 - 146

Published: Jan. 12, 2025

Language: Английский

Citations

0
Assessing platelet-derived extracellular vesicles for potential as therapeutic targets in cardiovascular diseases DOI Creative Commons
Xin Xin, Rory R. Koenen

Expert Opinion on Therapeutic Targets, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: Jan. 16, 2025

Introduction Cardiovascular disease (CVD) is the leading cause of death worldwide. Platelet-derived extracellular vesicles (PEV) have attracted extensive attention in cardiovascular research recent years because their cargo involved a variety pathophysiological processes, such as thrombosis, immune response, promotion or inhibition inflammatory angiogenesis well cell proliferation and migration.

Language: Английский

Citations

0
Once‐weekly glucagon‐like peptide receptor agonist polyethylene glycol loxenatide protects against major adverse cardiovascular events in patients with type 2 diabetes: a multicenter ambispective cohort study (FLYING trial) DOI Creative Commons
Jilin Li, Yu Tian, Liping Li

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(2)

Published: Feb. 1, 2025

Abstract This study aimed to determine the effects of polyethylene glycol loxenatide (PEG‐Loxe), a glucagon‐like peptide‐1 receptor agonist, on three‐point major adverse cardiovascular event (3P‐MACE) in patients with type 2 diabetes mellitus (T2DM). The was conducted six tertiary hospitals three cities China. Large language models were used retrospectively screen and include 12,341 T2DM who had either disease or risk factors. divided into PEG‐Loxe cohort (treated PEG‐Loxe, n = 1282) control incretin glucose‐lowering agents, 11,059). After median follow‐up 4.0 years, 3P‐MACE occurred 51 (4.0%) 1263 (11.4%) cohorts, respectively (hazard ratio [HR] 0.68, 95% confidence interval [CI] 0.49–0.94; p 0.019). In versus 21 (1.6%) 476 (4.3%) experienced nonfatal stroke (HR 0.63; 0.041), whereas 22 (1.7%) 545 (4.9%) myocardial infarction 0.66; 0.058), incidence death 8 (0.6%) 240 (2.2%), 0.56; 0.118). We found significantly lower first infarction, stroke, deaths than cohort.

Language: Английский

Citations

0
Genetic and Epigenetic Intersections in COVID-19-Associated Cardiovascular Disease: Emerging Insights and Future Directions DOI Creative Commons
Hussein Sabit, Borros Arneth, Afaf Altrawy

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 485 - 485

Published: Feb. 16, 2025

The intersection of COVID-19 and cardiovascular disease (CVD) has emerged as a significant area research, particularly in understanding the impact antiplatelet therapies like ticagrelor clopidogrel. been associated with acute complications, including myocardial infarction, thrombosis, heart failure, exacerbated by virus's ability to trigger widespread inflammation endothelial dysfunction. MicroRNAs (miRNAs) play critical role regulating these processes modulating gene expressions involved platelet function, inflammation, vascular homeostasis. This study explores potential miRNAs such miR-223 miR-126 biomarkers for predicting resistance or responsiveness patients disease. Identifying miRNA signatures linked drug efficacy could optimize treatment strategies at high risk thrombotic events during infection. Moreover, miRNA-mediated pathways offers new insights into how SARS-CoV-2 exacerbates CVD, through mechanisms cytokine storms damage. findings this research lead personalized therapeutic approaches, improving patient outcomes reducing mortality COVID-19-associated events. With global implications, addresses urgent need effective management CVD context COVID-19, focusing on integration molecular enhance precision therapy.

Language: Английский

Citations

0