Development of learning objectives to support undergraduate virology curriculum guidelines DOI Creative Commons
David Kushner, Mya Breitbart, Kari Debbink

et al.

Journal of Microbiology and Biology Education, Journal Year: 2024, Volume and Issue: 25(3)

Published: Oct. 21, 2024

ABSTRACT It has become increasingly important for microbiology educators to help students learn critical concepts of the discipline. This is particularly true in virology, where current challenges include increasing rates vaccine hesitancy, misinformation about COVID-19 pandemic, and controversy surrounding research on pathogens with pandemic potential. Having virology can attract more people field increase number who engage meaningful discourse issues relating However, limited virologists teach undergraduates, combined fact that many institutions lack stand-alone courses, results often being taught as a lectures within an undergraduate course (if it covered at all), which may or not be by individual trained virologist. To provide framework students, team educators, support from American Society Virology (ASV), developed curriculum guidelines use section another (D. B. Kushner et al., J Virol 96:e01305-22, 2022, https://doi.org/10.1128/jvi.01305-22 ). These are available ASV website ( https://asv.org/curriculum-guidelines/ assist implementing these guidelines, we created examples measurable learning objectives. perspective provides details objectives accompanies Boury al. this issue Journal Microbiology & Biology Education (25:e00126-24, 2024, https://doi.org/10.1128/jmbe.00126-24 ) recent revision overseen Microbiology.

Language: Английский

Targeting the PI3K/AKT signaling pathway in anticancer research: a recent update on inhibitor design and clinical trials (2020–2023) DOI
Dima A. Sabbah, Rima Hajjo, Sanaa K. Bardaweel

et al.

Expert Opinion on Therapeutic Patents, Journal Year: 2024, Volume and Issue: 34(3), P. 141 - 158

Published: March 3, 2024

Introduction Recent years have witnessed great achievements in drug design and development targeting the phosphatidylinositol 3-kinase/protein kinase-B (PI3K/AKT) signaling pathway, a pathway central to cell growth proliferation. The nearest neighbor protein-protein interaction networks for PI3K AKT show interplays between these target proteins which can be harnessed discovery. In this review, we discuss clinical of inhibitors PI3K/AKT past three years. We review detail structures, selectivity, efficacy, combination therapy thirty-five proteins, classified based on proteins. Approaches overcoming resistance minimizing toxicities are discussed. Future research directions developing combinational PROTACs also

Language: Английский

Citations

7
Antiviral polymers: Broad spectrum antiviral activity, antiviral mechanisms, and optimization for the treatment of various infections DOI
Imran Hasan, Fahad A. Alharthi, Ashok Kumar Bishoyi

et al.

Journal of Industrial and Engineering Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

1
Advancing the understanding and management of Mpox: insights into epidemiology, disease pathways, prevention, and therapeutic strategies DOI Creative Commons
Rima Hajjo, Osama H. Abusara, Dima A. Sabbah

et al.

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 15, 2025

Language: Английский

Citations

1
Targeting Non-Eosinophilic Immunological Pathways in COPD and AECOPD: Current Insights and Therapeutic Strategies DOI Creative Commons

Dur E Maknoon Razia,

Chencheng Gao,

Chao Wang

et al.

International Journal of COPD, Journal Year: 2025, Volume and Issue: Volume 20, P. 511 - 532

Published: March 1, 2025

COPD is a multifactorial illness characterized by long-term restriction of airflow and an inflammatory reaction in the lungs. The associated emphysema leads to breakdown alveolar proteins abnormal expansion lung air spaces. Chronic bronchitis caused same disease can result increased deposition structural proteins, narrowing airways, excessive mucus secretion leading acute exacerbation (AECOPD). most commonly prescribed medications for it, such as glucocorticoids bronchodilators, provide important therapeutic benefits, but they also have negative side effects, including immunosuppression infection. Therefore, it necessary develop treatment that specifically target immune system molecular components. This review focuses on non-eosinophilic aspects immunological modulation management. Since, existing literature extensively covers eosinophilic inflammation, this aims fill gap examining alternative pathways their implications. findings suggest targeting specific responses may enhance efficacy while minimizing adverse effects with traditional therapies. In summary, emphasizes importance advancing research into mechanisms COPD, prescribing development novel therapies more effectively manage disease.

Language: Английский

Citations

0
Decoding potential host protein targets against Flaviviridae using protein-protein interaction network DOI

Jaya Vasavi Pamidimukkala,

Bharath Raj Parthasarathy,

Sanjib Senapati

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143217 - 143217

Published: April 1, 2025

Language: Английский

Citations

0
Design and characterization of BSA-mycophenolic acid nanocomplexes: Antiviral activity exploration DOI

Mayra Alejandra Castañeda Cataña,

Martín M. Dodes Traian,

Andrea P. Rivas Marquina

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 265, P. 131023 - 131023

Published: March 19, 2024

Language: Английский

Citations

2
Targeted degrader technologies as prospective SARS-CoV-2 therapies DOI
Rabia Khurshid, Joseph M. Schulz, Jiaming Hu

et al.

Drug Discovery Today, Journal Year: 2023, Volume and Issue: 29(1), P. 103847 - 103847

Published: Nov. 28, 2023

Language: Английский

Citations

3
Exploring 4,7-Disubstituted Pyrimido[4,5-d]pyrimidines as Antiviral and Anticancer Agents DOI Creative Commons

Eleftheria A. Georgiou,

Konstantinos Paraskevas, Christina Koutra

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(23), P. 5549 - 5549

Published: Nov. 25, 2024

Thirteen new 4,7-disubstituted pyrimido[4,5-

Language: Английский

Citations

0
Development of learning objectives to support undergraduate virology curriculum guidelines DOI Creative Commons
David Kushner, Mya Breitbart, Kari Debbink

et al.

Journal of Microbiology and Biology Education, Journal Year: 2024, Volume and Issue: 25(3)

Published: Oct. 21, 2024

ABSTRACT It has become increasingly important for microbiology educators to help students learn critical concepts of the discipline. This is particularly true in virology, where current challenges include increasing rates vaccine hesitancy, misinformation about COVID-19 pandemic, and controversy surrounding research on pathogens with pandemic potential. Having virology can attract more people field increase number who engage meaningful discourse issues relating However, limited virologists teach undergraduates, combined fact that many institutions lack stand-alone courses, results often being taught as a lectures within an undergraduate course (if it covered at all), which may or not be by individual trained virologist. To provide framework students, team educators, support from American Society Virology (ASV), developed curriculum guidelines use section another (D. B. Kushner et al., J Virol 96:e01305-22, 2022, https://doi.org/10.1128/jvi.01305-22 ). These are available ASV website ( https://asv.org/curriculum-guidelines/ assist implementing these guidelines, we created examples measurable learning objectives. perspective provides details objectives accompanies Boury al. this issue Journal Microbiology & Biology Education (25:e00126-24, 2024, https://doi.org/10.1128/jmbe.00126-24 ) recent revision overseen Microbiology.

Language: Английский

Citations

0