Biomimetic nanocarriers: integrating natural functions for advanced therapeutic applications DOI Creative Commons
Hugo Félix Perini, Beatriz Sodré Matos, Carlo José Freire Oliveira

et al.

Beilstein Journal of Nanotechnology, Journal Year: 2024, Volume and Issue: 15, P. 1619 - 1626

Published: Dec. 16, 2024

Biomimetic nanocarriers, engineered to mimic the characteristics of native cells, offer a revolutionary approach in treatment various complex human diseases. This strategy enhances drug delivery by leveraging innate properties cellular components, thereby improving biocompatibility and targeting specificity. nanocarriers demonstrate significant advancements systems against cancer therapy, Alzheimer's disease, autoimmune diseases, viral infections such as COVID-19. Here, we address therapeutic applications biomimetic their promising for personalized medicine.

Language: Английский

Protein Nanoparticles as Vaccine Platforms for Human and Zoonotic Viruses DOI Creative Commons
Kush Kumar Pandey, Bikash R. Sahoo, Asit K. Pattnaik

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(6), P. 936 - 936

Published: June 9, 2024

Vaccines are one of the most effective medical interventions, playing a pivotal role in treating infectious diseases. Although traditional vaccines comprise killed, inactivated, or live-attenuated pathogens that have resulted protective immune responses, negative consequences their administration been well appreciated. Modern evolved to contain purified antigenic subunits, epitopes, antigen-encoding mRNAs, rendering them relatively safe. However, reduced humoral and cellular responses pose major challenges these subunit vaccines. Protein nanoparticle (PNP)-based garnered substantial interest recent years for ability present repetitive array antigens improving immunogenicity enhancing responses. Discovery characterisation naturally occurring PNPs from various living organisms such as bacteria, archaea, viruses, insects, eukaryotes, computationally designed structures approaches link PNPs, paved way unprecedented advances field vaccine technology. In this review, we focus on some widely used optimally suitability promising platforms displaying native-like human viral Such hold great promise combating emerging re-emerging diseases efficacy safety.

Language: Английский

Citations

5
Functionally Designed Nanovaccines against SARS-CoV-2 and Its Variants DOI Creative Commons
Yue Xi, Rongrong Ma, Shuo Li

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(7), P. 764 - 764

Published: July 12, 2024

COVID-19, generated by SARS-CoV-2, has significantly affected healthcare systems worldwide. The epidemic highlighted the urgent need for vaccine development. Besides conventional vaccination models, which include live-attenuated, recombinant protein, and inactivated vaccines, nanovaccines present a distinct opportunity to progress research offer convenient alternatives. This review highlights many widely used nanoparticle vectors, outlines their benefits drawbacks, examines recent developments in vaccines prevent SARS-CoV-2. It also offers thorough overview of advantages including an enhanced host immune response, multivalent antigen delivery, efficient drug delivery. main objective is provide reference development innovative antiviral vaccines.

Language: Английский

Citations

2
Nature-inspired innovations: unlocking the potential of biomimicry in bionanotechnology and beyond DOI Creative Commons
Sergio A. Paniagua, Diego Batista Menezes, María Murillo

et al.

Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)

Published: Nov. 21, 2024

Bionanotechnology research has surged to the forefront of scientific innovation, propelling exploration cutting-edge technologies and interdisciplinary collaboration. Biomimicry, which harnesses nature's ingenuity, drives development novel research-based solutions in diverse fields such as vaccines, medicine, biomedical devices. Nature's role is becoming increasingly pivotal addressing complex challenges related environmental conservation, human health, pandemic preparedness, including those posed by SARS-CoV-2 other emerging pathogens. Progress this domain encompasses understanding nature´s mechanisms develop advanced materials inspired biological structures. Biomimetic innovations have potential revolutionize industries, reduce impacts, facilitate a more harmonious relationship between humans nature while considering bioethics, underlining necessity conducting responsible implementing biomimetic advancements conscientiously. As biomimicry continues grow, integrating ethical guidelines policies will ensure these nature-inspired technologies' sustainable application, ultimately contributing resilient adaptive society. This mini-review article broadly overviews bionanotechnology applications based on natural examples.

Language: Английский

Citations

1
Bacterial Membrane Vesicles as a Novel Vaccine Platform against SARS-CoV-2 DOI
Çiğdem Yılmaz Çolak

Current Microbiology, Journal Year: 2024, Volume and Issue: 81(10)

Published: Aug. 20, 2024

Language: Английский

Citations

1
Research Progress of Nanomaterials for Prevention, Diagnosis, and Treatment of SARS-CoV-2 DOI

Yachan Feng,

Haojie Zhang,

Jiangtao Shao

et al.

BioNanoScience, Journal Year: 2024, Volume and Issue: 14(2), P. 1961 - 1977

Published: Feb. 6, 2024

Language: Английский

Citations

0
Surface Modification Engineering of Graphene for Enhanced Trapping and Disruptive Interaction with Sars-Cov-2 3cl Mpro DOI
Jiawen Wang,

Yi Yu,

Huilong Dong

et al.

Published: Jan. 1, 2024

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI

Language: Английский

Citations

0
Molecular Epidemiology of SARS-CoV-2 and Correlation of its Clinical Severity with Different Biochemical Parameters: A Retrospective Study DOI Creative Commons
Maria Bibi, Braira Wahid,

Syed Sib tul Hassan Shah

et al.

BioScientific Review, Journal Year: 2024, Volume and Issue: 6(1), P. 70 - 80

Published: May 9, 2024

Background Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is an infectious disease that was first identified in December 2019 Wuhan, the capital of China's Hubei province. Since then, it has spread globally, resulting ongoing SARS-CoV-2 pandemic. In Pakistan, over 1.5 million cases have been reported since February 2020 (when case reported). Method This retrospective study conducted by classifying data 136 patients into three groups, namely asymptomatic (n = 84), mild 36), and severe 16). The analyzed using IBM SPSS (version 21). Results Age gender showed a non-significant relationship with SARS-CoV-2. Biochemical markers D-DIMER, FERRITIN, CRP, PT significant results p-values 0.001, 0.048, 0.009, respectively (p<0.05). On contrary, APTT (p= 0.146). Conclusion It concluded biochemical parameters seen as best prediction to gauge infection severity. Furthermore, this research established correlation severity also highlighted use these biomarkers diagnostic therapeutic biomarkers.

Language: Английский

Citations

0
Biomimetic nanocarriers: integrating natural functions for advanced therapeutic applications DOI Creative Commons
Hugo Félix Perini, Beatriz Sodré Matos, Carlo José Freire Oliveira

et al.

Beilstein Journal of Nanotechnology, Journal Year: 2024, Volume and Issue: 15, P. 1619 - 1626

Published: Dec. 16, 2024

Biomimetic nanocarriers, engineered to mimic the characteristics of native cells, offer a revolutionary approach in treatment various complex human diseases. This strategy enhances drug delivery by leveraging innate properties cellular components, thereby improving biocompatibility and targeting specificity. nanocarriers demonstrate significant advancements systems against cancer therapy, Alzheimer's disease, autoimmune diseases, viral infections such as COVID-19. Here, we address therapeutic applications biomimetic their promising for personalized medicine.

Language: Английский

Citations

0