Pathogenesis of influenza and SARS-CoV-2 co-infection at the extremes of age: decipher the ominous tales of immune vulnerability

Advanced Biotechnology, Journal Year: 2025, Volume and Issue: 3(1)

Published: Jan. 21, 2025

The co-circulation of influenza and SARS-CoV-2 has led to co-infection events, primarily affecting children older adults, who are at higher risk for severe disease. Although prevalence is relatively low, it associated with worse outcomes compared mono-infections. Previous studies have shown that the depend on multiple factors, including viral interference, virus-host interaction host response. Children elderly exhibit distinct patterns antiviral response, which involve airway epithelium, mucociliary clearance, innate adaptive immune cells, inflammatory mediators. This review explores pathogeneses co-infection, focusing responses in elderly. By comparing immature immunity senescence we aim provide insights clinical management cases.

Language: Английский

---

A meta-meta-analysis of co-infection, secondary infections, and antimicrobial resistance in COVID-19 patients

Journal of Infection and Public Health, Journal Year: 2023, Volume and Issue: 16(10), P. 1562 - 1590

Published: July 18, 2023

The newly discovered coronavirus SARS-CoV-2 has sparked a worldwide pandemic of COVID-19, which caused havoc on medical infrastructures, economies, and cultures around the world. Determining whole scenario is essential since variants sub-variants keep appearing after vaccinations booster doses. objective this secondary meta-analysis to analysis co-infection, infections, antimicrobial resistance (AMR) in COVID-19 patients. This study used five significant databases conduct systematic review an overlap evaluate pooled estimates co-infections infections. summary showed overall co-infection effect 26.19% (95% confidence intervals CI: 21.39 31.01, I2=98.78, n = 14 meta-analysis) among patients with COVID-19. A coinfection 11.13% 9.7 12.56, I2=99.14, 11 for bacteria; 9.69% 1.21 7.90, I2 =98.33) fungal 3.48% 2.15 4.81, =95.84) viruses. infection 19.03% 9.53 28.54, =85.65) was from 2 meta-analyses (Ave: 82 primary studies). first that compiles results all previous three years into single source offers strong proof infections Early detection AMR crucial order effectively effective treatment.

Language: Английский

---

Prevalence and associated outcomes of coinfection between SARS-CoV-2 and influenza: a systematic review and meta-analysis

International Journal of Infectious Diseases, Journal Year: 2023, Volume and Issue: 136, P. 29 - 36

Published: Aug. 29, 2023

ObjectivesTo estimate the prevalence of influenza co-infection in COVID-19 patients and investigate its association with severe clinical outcomes.MethodsWe systematically searched Web Science, PubMed, Scopus, Embase, The Cochrane Library, CNKI for studies published between January 1, 2020 May 31, 2023. Meta-analysis was performed to pooled impact on outcomes. Systematic review registered PROSPERO (CRD42023423113).ResultsA total 95 involving 62,107 were included. virus 2.45% (95% CI: 1.67%-3.58%), a high proportion A. Compared mono-infected (COVID-19 only), odds ratio (OR) outcomes (including Intensive Care Unit admission (OR = 2.20, 95% 1.68-2.87, P < 0.001), mechanical ventilation support 2.73, 1.46-5.10, 0.002), mortality 2.92, 1.16-7.30, 0.022)) significantly higher among co-infected A.ConclusionAlthough is low, are at risk Enhanced identification both viruses, as well individualized treatment protocols co-infection, recommended reduce occurrence serious disease future.

Language: Английский

---

Seasonal Shifts in Influenza, Respiratory Syncytial Virus, and Other Respiratory Viruses After the COVID-19 Pandemic: An Eight-Year Retrospective Study in Jalisco, Mexico

Viruses, Journal Year: 2024, Volume and Issue: 16(12), P. 1892 - 1892

Published: Dec. 8, 2024

The coronavirus disease 2019 (COVID-19) pandemic profoundly disrupted the epidemiology of respiratory viruses, driven primarily by widespread non-pharmaceutical interventions (NPIs) such as social distancing and masking. This eight-year retrospective study examines seasonal patterns incidence influenza virus, syncytial virus (RSV), other viruses across pre-pandemic, pandemic, post-pandemic phases in Jalisco, Mexico. Weekly case counts were analyzed using an interrupted time series (ITS) model, segmenting timeline into these three distinct phases. Significant reductions circulation observed during followed atypical resurgences NPIs relaxed. Influenza displayed alternating subtype dominance, with A H3 prevailing 2022, B surging 2023, H1N1 increasing thereafter, reflecting potential immunity gaps. RSV activity was marked earlier onset higher intensity post-pandemic. Other including human rhinovirus/enterovirus (HRV/HEV) parainfluenza (HPIV), showed altered dynamics, some failing to return pre-pandemic seasonality. These findings underscore need for adaptive surveillance systems vaccination strategies address evolving viral patterns. Future research should investigate long-term public health implications, focusing on vaccination, clinical outcomes, healthcare preparedness.

Language: Английский

---

Clinical Performance of the BD Respiratory Viral Panel for BD MAX™ System in Detecting SARS-CoV-2, Influenza A and B, and Respiratory Syncytial Virus

Diagnostic Microbiology and Infectious Disease, Journal Year: 2024, Volume and Issue: 110(3), P. 116482 - 116482

Published: Aug. 6, 2024

Using a nasopharyngeal (NP) or anterior nasal (NS) swab from prospectively collected retrospective specimens, we assessed the clinical performance of BD Respiratory Viral Panel (BD RVP) for MAX System against FDA-cleared authorized comparators. Across prospective and positive percent agreement (PPA) was ≥ 98.4% SARS-CoV-2, 96.7% influenza (flu) A, 91.7% respiratory syncytial virus (RSV), 100% flu B (retrospective only) while negative (NPA) 97.7% across all targets, leading to assay FDA clearance. A head-to-head comparison NS versus NP results with RVP also performed; PPA 90% NPA 98.2% RSV. These findings confirm that performs well detection differentiation three viruses in strong interrater agreements comparisons.

Language: Английский

---

Viral Etiologies of Pneumonia and Bronchiolitis in Hospitalized Children During the COVID-19 Pandemic

Archives of Pediatric Infectious Diseases, Journal Year: 2024, Volume and Issue: 12(3)

Published: Aug. 13, 2024

Background: Viral agents are the most common pathogens that can infect children between ages of two and five. Although previous studies worldwide have investigated viral causes lower respiratory infections before pandemic, researchers focused on coronavirus with increase in during pandemic. However, it became evident other viruses should also be monitored. Objectives: We aimed to detect cases pneumonia bronchiolitis over 2 months old COVID-19 emergency Mashhad. Methods: All hospitalized admitted Akbar Hospital, Mashhad, Iran, from January 2021 2022, a final evidence-based diagnosis or by an expert pediatrician were included. Convenient nasopharyngeal samples taken analyzed multiplex polymerase chain reaction (PCR). Moreover, patients’ on-admission presentations recorded. Data reported using descriptive statistics IBM SPSS software. Results: assessed 102 average age 3.80 ± 3.40 years who (N = 97) 5). syncytial virus (RSV) frequent patients, respectively. The symptom was cough, occurring 90% study population. Wheezing heard 4 out 5 cases, while crackles more patients (36.1%). pulse rates significantly higher than those (P < 0.05). Results showed monocyte counts different groups, patients. Conclusions: provided valuable insights into clinical laboratory characteristics children, including etiology, symptoms, signs, vital findings. These findings aid healthcare professionals diagnosing managing these children. Notably, accurate follow-up is suggested, especially for coinfections might cause morbidity mortality

Language: Английский

---

Seasonal Respiratory Virus Circulation in a Tertiary Care Hospital in Greece

European Journal of Biomedical Research, Journal Year: 2023, Volume and Issue: 2(3), P. 6 - 11

Published: July 2, 2023

Background: The COVID-19 pandemic caused by the novel SARS-CoV-2 virus affected health care systems and public worldwide dramatically. Several measures were applied in order to prevent or stop rapid transmission of subsequent disease, such as lockdowns, physical distancing, strictly hygiene, along with travel restrictions. Global population after vaccination programs against carried out, is facing a “tripledemic” situation threat, co-existance SARS-CoV-2, influenza RSV. aim present study was evaluate co-existence RSV, well correlation gender, age, Cts doses. Methods: A total 302 patients included study. All admitted emergency department General Hospital Nikea, Piraeus common upper respiratory tract symptoms suspected for between March July 2022. Patients’ doses, results from RT-PCR detection RSV Influenza viruses recorded. Results: 139 male 163 female, aged 18-94 years. Out study, 206 vaccinated 96 not vaccinated. Among 97 109 female. percentage 3.3% had received one dose, 16.9% two 47.7% three. Moreover, 88 presented infection symptoms; 81 positive test result. We detected 15 cases co-infection SaRS-CoV-2 only case, virus. Conclusions: majority GHNP clinical manifestations significantly lower rate having 2 compared 3 out doses up 1 dose. Ct values pathogens 10-17. Co-infection patient.

Language: Английский

---