The effects of amino acid substitution of spike protein and genomic recombination on the evolution of SARS-CoV-2

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: July 25, 2023

Over three years’ pandemic of 2019 novel coronavirus disease (COVID-19), multiple variants and subvariants have emerged successively, outcompeted earlier become predominant. The sequential emergence reflects the evolutionary process mutation-selection-adaption severe acute respiratory syndrome 2 (SARS-CoV-2). Amino acid substitution/insertion/deletion in spike protein causes altered viral antigenicity, transmissibility, pathogenicity SARS-CoV-2. Early pandemic, D614G mutation conferred virus with advantages over previous increased it also laid a conservative background for subsequent substantial mutations. role genomic recombination evolution SARS-CoV-2 raised increasing concern occurrence recombinants such as Deltacron, XBB.1.5, XBB.1.9.1, XBB.1.16 late phase pandemic. Co-circulation different co-infection immunocompromised patients accelerate recombinants. Surveillance variations, particularly recombination, is essential to identify ongoing changes genome antigenic epitopes thus leads development new vaccine strategies interventions.

Language: Английский

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Characterisation of the antibody-mediated selective pressure driving intra-host evolution of SARS-CoV-2 in prolonged infection

PLoS Pathogens, Journal Year: 2024, Volume and Issue: 20(10), P. e1012624 - e1012624

Published: Oct. 15, 2024

Neutralising antibodies against the SARS-CoV-2 spike (S) protein are major determinants of protective immunity, though insufficient antibody responses may cause emergence escape mutants. We studied humoral immune response causing intra-host evolution in a B-cell depleted, haemato-oncologic patient experiencing clinically severe, prolonged infection with virus lineage B.1.177.81. Following bamlanivimab treatment at an early stage infection, developed bamlanivimab-resistant mutation, S:S494P. After five weeks apparent genetic stability, additional substitutions and deletions within N-terminal domain (NTD) receptor binding (RBD) S was observed. Notably, composition frequency mutations changed short period unprecedented dynamic. The triple mutant S:Delta141-4 E484K S494P became dominant until elimination. Routine serology revealed no evidence patient. A detailed analysis variant-specific by pseudotyped neutralisation test, surrogate immunoglobulin-capture enzyme immunoassay showed that onset IgM-dominated coincided appearance mutations. formation neutralising correlated One year later, experienced mild re-infection Omicron BA.1.18, which treated sotrovimab resulted increase Omicron-reactive antibodies. In conclusion, endogenous immunocompromised NTD RBD virus. Although elimination ultimately achieved, this escaped detection routine diagnosis created situation temporarily favouring rapid various mutants known epidemiological relevance.

Language: Английский

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The Lambda Variant in Argentina: Analyzing the Evolution and Spread of SARS-CoV-2 Lineage C.37

Viruses, Journal Year: 2023, Volume and Issue: 15(6), P. 1382 - 1382

Published: June 16, 2023

The second wave of COVID-19 occurred in South America early 2021 and was mainly driven by Gamma Lambda variants. In this study, we aimed to describe the emergence local genomic diversity SARS-CoV-2 variant Argentina, from its initial entry into country until detection ceased. Molecular surveillance conducted on 9356 samples Argentina between October 2020 April 2022, sequencing, phylogenetic, phylogeographic analyses were performed. Our findings revealed that first detected January steadily increased frequency it peaked 2021, with continued throughout year. Phylodynamic showed at least 18 introductions occurred, nine them having evidence onward transmission. spatial–-temporal reconstruction Argentine clades associated sequences Latin suggested an diversification Metropolitan Area Buenos Aires before spreading other regions Argentina. Genetic genome allowed us mutational patterns detect rare mutations immunocompromised patient. study highlights importance identifying introduction geographical distribution variant, as well monitoring could be involved evolutionary leaps characterize variants concern.

Language: Английский

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Combating HTLV-1 infections with Taxus baccata phytoconstituents: Molecular mechanisms potential anti-ATLL agents

Pharmacological Research - Natural Products, Journal Year: 2024, Volume and Issue: 4, P. 100036 - 100036

Published: April 16, 2024

Language: Английский

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Current Progress in Genomic and Genetic Research on Human Viral Diseases

Frontiers research topics, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

it is a pioneering approach to the world of academia, radically improving way scholarly research managed.The grand vision Frontiers where all people have an equal opportunity seek, share and generate knowledge.Frontiers provides immediate permanent online open access its publications, but this alone not enough realize our goals. journal seriesThe series multi-tier interdisciplinary set openaccess, journals, promising paradigm shift from current review, selection dissemination processes in academic publishing.All journals are driven by researchers for researchers; therefore, they constitute service community.At same time, operates on revolutionary invention, tiered publishing system, initially addressing specific communities scholars, gradually climbing up broader public understanding, thus serving interests lay society, too. Dedication qualityEach article landmark highest quality, thanks genuinely collaborative interactions between authors review editors, who include some world's best academicians.Research must be certified peers before entering stream knowledge that may eventually reach -and shape society; only applies most rigorous unbiased reviews.Frontiers revolutionizes freely delivering outstanding research, evaluated with no bias both social point view.By applying advanced information technologies, catapulting into new generation.

Language: Английский

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