Efficacy and clinical potential of phage therapy in treating methicillin-resistant Staphylococcus aureus (MRSA) infections: A review

European Journal of Microbiology and Immunology, Journal Year: 2024, Volume and Issue: 14(1), P. 13 - 25

Published: Feb. 2, 2024

Staphylococcus aureus infections have already presented a substantial public health challenge, encompassing different clinical manifestations, ranging from bacteremia to sepsis and multi-organ failures. Among these infections, methicillin-resistant S. (MRSA) is particularly alarming due its well-documented resistance multiple classes of antibiotics, contributing significantly global mortality rates. Consequently, the urgent need for effective treatment options has prompted growing interest in exploring phage therapy as potential non-antibiotic against MRSA infections. Phages represent class highly specific bacterial viruses known their ability infect certain strains. This review paper explores phages low toxicity auto-dosing capabilities. The also discusses synergistic effect phage-antibiotic combination (PAC) promising results vitro animal model studies, which could lead extensive human trials. However, clinicians establish adhere standard protocols governing administration implementation. Prominent trials are needed develop advance intervention, meeting regulatory guidelines, logistical requirements, ethical considerations, potentially revolutionizing

Language: Английский

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Lytic bacteriophages induce the secretion of antiviral and proinflammatory cytokines from human respiratory epithelial cells

PLoS Biology, Journal Year: 2024, Volume and Issue: 22(4), P. e3002566 - e3002566

Published: April 23, 2024

Phage therapy is a therapeutic approach to treat multidrug-resistant (MDR) infections that employs lytic bacteriophages (phages) eliminate bacteria. Despite the abundant evidence for its success as an antimicrobial in Eastern Europe, there scarce data regarding effects on human host. Here, we aimed understand how phages interact with cells of airway epithelium, tissue site colonized by bacterial biofilms numerous chronic respiratory disorders. Using panel Pseudomonas aeruginosa and epithelial (AECs) derived from person cystic fibrosis (CF), determined interactions between depend specific phage properties well physiochemical features microenvironment. Although poor at internalizing phages, epithelium responds exposure changing transcriptional profile secreting antiviral proinflammatory cytokines correlate families. Overall, our findings indicate mammalian responses are heterogenous could potentially alter way local defenses aid clearance during therapy. Thus, besides receptor specificity particular isolate, criteria select should be expanded include cell responses.

Language: Английский

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Does Phage Therapy Need a Pan-Phage?

Pathogens, Journal Year: 2024, Volume and Issue: 13(6), P. 522 - 522

Published: June 20, 2024

The emergence of multidrug-resistant bacteria is undoubtedly one the most serious global health threats. One response to this threat that has been gaining momentum over past decade 'phage therapy'. According this, lytic bacteriophages are used for treatment bacterial infections, either alone or in combination with antimicrobial agents. However, ensure efficacy and broad applicability phage therapy, several challenges must be overcome. These encompass development methods strategies host range manipulation bypass resistance mechanisms developed by pathogenic bacteria, as case since advent antibiotics. As our knowledge understanding interactions between phages their hosts evolves, key issue define each application. In article, we discuss factors affect how determines classification into different categories action. For group, recent representative examples provided, together suggestions on groups can combat certain types infections. available methodologies expansion, through sequential adaptation a new pathogen genetic engineering techniques, also reviewed.

Language: Английский

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Bacteriophage Bioengineering: A Transformative Approach for Targeted Drug Discovery and Beyond

Pathogens, Journal Year: 2023, Volume and Issue: 12(9), P. 1179 - 1179

Published: Sept. 20, 2023

Bacteriophages, the viruses that infect and replicate within bacteria, have long been recognized as potential therapeutic agents against bacterial infections [...].

Language: Английский

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Bacteriophages: Status quo and emerging trends toward one health approach

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 908, P. 168461 - 168461

Published: Nov. 13, 2023

Language: Английский

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