Neurodevelopmental delay in children exposed to maternal SARS-CoV-2 in-utero

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 24, 2024

Abstract It is unclear if SARS CoV-2 infection during pregnancy associated with adverse neurodevelopmental repercussions to infants. We assessed pediatric outcomes in children born mothers laboratory-confirmed pregnancy. Neurodevelopmental of in-utero exposed were compared that pre-pandemic control Los Angeles (LA), CA, USA and Rio de Janeiro, Brazil. Bayley Scales Infant Toddler Development, 3rd edition (Bayley-III), the gold standard tool for evaluating neurodevelopment until 36 months age Ages Stages Questionnaires (ASQ-3), a frequently used screening instrument this same group assessment tools used. Developmental delay (DD) was defined as having score < − 2 SD below norm (< 70) at least one three Bayley-III domains, (cognitive, motor or language) cut-off (dark zone) five ASQ-3 domains (communication, gross motor, fine problem solving, personal-social). Exposed between April 2020 December 2022 while January 2016 2019. testing performed 300 total: 172 COVID-19 5–30 128 6–38 age. results demonstrated 12 (9.4%) had DD versus controls (1.6%), p = 0.0007. Eight 44 additional on testing. Fully, 20 (11.6%) 0.0006 DD. In Rio, 12% 2.6% controls, 0.02 LA, 5.7% 0 0.12 Severe/critical maternal predicted average cohort (OR 2.6, 95% CI 1.1–6.4). Children antenatal have tenfold higher frequency should be offered follow-up.

Language: Английский

Expression of the mucin-like glycoprotein CD24 and its ligand siglec-10 in placentas with acute and post SARS-CoV-2 infection

Journal of Reproductive Immunology, Journal Year: 2024, Volume and Issue: 167, P. 104400 - 104400

Published: Nov. 27, 2024

Language: Английский