Genomic insight into COVID-19 severity in MAFLD patients: a single-center prospective cohort study

Frontiers in Genetics, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 4, 2024

This study investigated the influence of single nucleotide polymorphisms (SNPs) in genes associated with interferon pathway (IFNAR2 rs2236757), antiviral response (OAS1 rs10774671, OAS3 rs10735079), and viral entry (ACE2 rs2074192) on COVID-19 severity their association nonalcoholic fatty liver disease (MAFLD). We did not observe a significant between SNPs severity. While IFNAR2 rs2236757 A allele was correlated higher creatinine levels upon admission G lower band neutrophils discharge, these findings require further investigation. The distribution OAS gene (rs10774671 rs10735079) differ MAFLD patients non-MAFLD patients. Our population's ACE2 rs2074192 genotypes alleles differed from that European reference population. Overall, our suggest specific may be major contributors to patient population, highlighting potential role other genetic factors environmental influences.

Language: Английский

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The influence of genetic polymorphisms on cytokine profiles in pediatric COVID-19: a pilot study

Frontiers in Pediatrics, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 24, 2025

Recent studies have underscored the importance of genetic factors in predicting COVID-19 susceptibility and severity. While cytokine storms are crucial disease severity, predisposition significantly influences immune responses. Our study examined genes related to SARS-CoV-2 invasion (ACE2 rs2074192) interferon-induced immunity (IFNAR2 rs2236757, TYK2 rs2304256, OAS1 rs10774671, OAS3 rs10735079). Additionally, we investigated linked Kawasaki (CD40 rs4813003, FCGR2A rs1801274, CASP3 rs113420705) that play roles immunogenesis. The pilot study, which involved 75 pediatric patients aged one month 17 years [43 with active COVID-19, children multisystem inflammatory syndrome (MIS-C), 15 healthy controls], was conducted Ternopil, Ukraine. Gene polymorphism studied for all patients. ELISA kits were used interleukin studies, including Human IL-1β (Interleukin 1 Beta), IL-6 6), IL-8 8), IL-12 12), IFN-α (Interferon Alpha), TNF-α (Tumor Necrosis Factor Alpha). Statistical analysis performed using IBM SPSS Statistics 21 GraphPad Prism 8.4.3. identified significant gene-cytokine associations ACE2 rs2074192 T allele correlated increased IL-1β, IL-6, IL-8, TNF-α. IFNAR2 rs2236757 A elevated levels low levels, while rs10774671 carriers also exhibited lower levels. prognostically determining infected SARS-CoV-2. gene rs10735079 associated changes precisely a high level. CD40 rs4813003 C had higher IL-12. results our revealed correlation between rs1801274 (A/G). rs113420705 led an increase IL-6. These findings enhance understanding may hold promise developing targeted interventions providing personalized medical approach each patient.

Language: Английский

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Genetic Predictors of Paxlovid Treatment Response: The Role of IFNAR2, OAS1, OAS3, and ACE2 in COVID-19 Clinical Course

Journal of Personalized Medicine, Journal Year: 2025, Volume and Issue: 15(4), P. 156 - 156

Published: April 17, 2025

Background: This study investigated the role of genetic polymorphisms in IFNAR2, OAS1, OAS3, and ACE2 as predictors Paxlovid treatment response, specifically examining their influence on clinical course laboratory parameters COVID-19 patients. Methods: We analyzed impact genes associated with interferon pathway (IFNAR2 rs2236757), antiviral response (OAS1 rs10774671, OAS3 rs10735079), viral entry (ACE2 rs2074192) individuals treated Paxlovid. Results: Our findings suggest that variations these may modulate immune coagulation pathways context during infection. Specifically, IFNAR2 rs2236757 G allele was alterations inflammatory markers, while OAS1 influenced parameters. Furthermore, specific genotypes were linked to changes such oxygen saturation, leukocyte count, liver function markers Paxlovid-treated Conclusions: These results highlight potential considering factors understanding individual responses informing future personalized approaches.

Language: Английский

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The Apoprotein E4 isotype does not affect the severity of COVID-19 infection and other flu-like syndromes

Journal of Medical Microbiology, Journal Year: 2025, Volume and Issue: 74(1)

Published: Jan. 22, 2025

Impact of e4 allele on flu-like syndromes The ɛ4 has no influence syndrome, including COVID-19. COVID-19 severity was associated with BMI, male sex, comorbidities and IL-4 levels.

Language: Английский

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Differences in the Clinical Manifestations and Host Immune Responses to SARS-CoV-2 Variants in Children Compared to Adults

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 13(1), P. 128 - 128

Published: Dec. 26, 2023

The COVID-19 pandemic challenged the medical field to rapidly identify and implement new approaches diagnosis, treatment prevention of SARS-CoV-2 infections. scientific community also needed initiate basic, translational, clinical epidemiological studies understand pathophysiology this family viruses, which continues evolve with emergence genetic variants. One earliest observations that provided a framework for research was finding that, in contrast most other respiratory children developed less severe acute post-acute disease compared adults. Although manifestations infection changed each wave pandemic, dominated by evolving viral variants, differences severity between adults persisted. Comparative immunologic have shown mount more vigorous local innate response characterized activation interferon pathways recruitment cells mucosa, may mitigate against hyperinflammatory adaptive systemic cytokine release likely contributed outcomes including distress syndrome In review, responses during different waves are discussed.

Language: Английский

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Genomic Insight into the COVID-19 Severity in MAFLD Patients: A Single-Center Prospective Cohort Study

Published: March 27, 2024

This study investigated the influence of single nucleotide polymorphisms (SNPs) in genes asso-ciated with interferon pathway (IFNAR2 rs2236757), antiviral response (OAS1 rs10774671, OAS3 rs10735079), and viral entry (ACE2 rs2074192) on COVID-19 severity their association non-alcoholic fatty liver disease (MAFLD). We did not observe a significant between SNPs severity. While IFNAR2 rs2236757 A allele correlated higher creatinine levels upon admission G lower band neu-trophils discharge, these findings require further investigation. The distribution OAS gene (rs10774671, rs10735079 differ MAFLD non-MAFLD patients. Our population's ACE2 rs2074192 genotypes alleles differed from European reference population. Overall, our suggest that specific may be major contributors to patient population, highlighting potential role other genetic factors environmental influences.

Language: Английский

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Association of OAS1 gene polymorphism with the severity of COVID‑19 infection

World Academy of Sciences Journal, Journal Year: 2024, Volume and Issue: 6(6)

Published: Oct. 9, 2024

The ongoing coronavirus disease 2019 (COVID‑19) pandemic has underscored the critical need to investigate host genetic factors that may influence susceptibility and severity. Among these, 2'‑5'‑oligoadenylate synthase 1 (OAS1) single nucleotide polymorphism (SNP) rs10774671 been implicated in antiviral response against coronaviruses clinical outcomes. aim of present retrospective study was association between OAS1 gene severity COVID‑19. A total 200 subjects were enrolled, including 75 healthy controls 125 patients with SNP assessed using PCR‑RFLP analysis. findings revealed an upward trend prevalence allele among individuals, who developed a severe course Specifically, 17.8% infection carried GG genotype, 52.8% had GA genotype 30.4% AA (P=0.0001). Notably, exclusively detected COVID‑19 (P<0.0001). Moreover, frequency markedly higher than G Multivariate analysis individuals 6.8‑fold greater likelihood progressing more (odds ratio, 6.86; 95% CI, 2.83‑16.63; P<0.0001). Thus, holds promise as potential marker could be valuable predicting progression outcome infection.

Language: Английский

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Rare host variants in ciliary expressed genes contribute to COVID-19 severity in Bulgarian patients

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 14, 2024

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), a pneumonia with extremely heterogeneous clinical presentation, ranging from asymptomatic to severely ill patients. Previous studies have reported links between the presence of host genetic variants and outcome COVID-19 infection. In our study, we used whole exome sequencing in cohort 444 SARS-CoV-2 patients, admitted hospital period October-2020-April-2022, search for associations rare pathogenic/potentially pathogenic progression. We gene prioritization-based analysis genes that been by studies. Although did not identify correlation outcome, critically patients detected known mutations number associated severe related cardiovascular disease, primary ciliary dyskinesia, cystic fibrosis, DNA damage repair response, coagulation, immune disorder, hemoglobin subunit β, others. Additionally, report 93 novel found infected who required intubation or died. A network showed main component, consisting 13 highly interconnected epithelial cilium. conclusion, may influenced Bulgarian

Language: Английский

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Changes in lipid profile parameters depending on the a1166c polymorphism of the angiotensin II type I receptor gene as a predictor of arterial hypertension

Wiadomości Lekarskie, Journal Year: 2024, Volume and Issue: 77(8), P. 1554 - 1561

Published: Jan. 1, 2024

Aim: To investigate lipid profile parameters depending the polymorphism of A1166C I type gene receptor angiotensin II as a predictor arterial hypertension.

Language: Английский

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Gene Variants of the OAS/RNase L Pathway and Their Association with Severity of Symptoms and Outcome of SARS-CoV-2 Infection

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(4), P. 426 - 426

Published: April 17, 2024

Introduction: The interferon pathway plays a critical role in triggering the immune response to SARS-CoV-2, and these gene variants may be involved severity of COVID-19. This study aimed analyze frequency three OAS RNASEL with occurrence COVID-19 symptoms disease outcome. Methods: cross-sectional included 104 patients SARS-CoV-2 infection, which 34 were asymptomatic COVID-19, 70 symptomatic cases. rs486907 (RNASEL), rs10774671 (OAS1), rs1293767 (OAS2), rs2285932 (OAS3) screened discriminated using predesigned 5′-nuclease assay TaqMan probes. Results: Patients allele C OAS2 (OR = 0.36, 95% CI: 0.15–0.83, p 0.014) T OAS3 0.39, 0.2–0.023, 0.023) have lower susceptibility developing genotype frequencies (G/G, G/C, C/C) for that comparison 64.7%, 29.4%, 5.9% group 95.2%, 4.8%, 0% severe (p < 0.05). Conclusions: Our data indicate individuals carrying are less likely develop suggesting genetic variations confer protective effect among Mexican population. Furthermore, observed differences between those emphasize potential as markers severity. These insights enhance our understanding factors influence course underscore screening identifying at increased risk outcomes.

Language: Английский

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