Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 329 - 374
Published: Nov. 29, 2024
Military Medical Research, Journal Year: 2023, Volume and Issue: 10(1)
Published: April 27, 2023
Abstract A bio-inspired strategy has recently been developed for camouflaging nanocarriers with biomembranes, such as natural cell membranes or subcellular structure-derived membranes. This endows cloaked nanomaterials improved interfacial properties, superior targeting, immune evasion potential, and prolonged duration of systemic circulation. Here, we summarize recent advances in the production application exosomal membrane-coated nanomaterials. The structure, manner which exosomes communicate cells are first reviewed. is followed by a discussion types their fabrication methods. We then discuss applications biomimetic membrane-cloaked tissue engineering, regenerative medicine, imaging, treatment neurodegenerative diseases. Finally, appraise current challenges associated clinical translation membrane-surface-engineered nanovehicles evaluate future this technology.
Language: Английский
Citations
39
Deleted Journal, Journal Year: 2023, Volume and Issue: 1(4)
Published: Oct. 1, 2023
Abstract Diabetic wounds have imposed a significant burden on both patients and society with prolonged healing processes hindered by dysfunctional skin repair cells. Small extracellular vesicles (sEVs), as the important media for intercellular communications, show promising therapeutic potential in treating diabetic restoring cellular functions. However, low yields limited bio‐function of sEVs greatly challenge their large‐scale clinical use. Here, we briefly overview biogenesis uptake sEVs, emphasize current advances improving optimizing function engineering approaches, summarize applications engineered wound treatment. Furthermore, undissolved issues during transformation are also discussed. This critical review aims to provide meaningful guidance future management wounds.
Language: Английский
Citations
25
Molecular Aspects of Medicine, Journal Year: 2024, Volume and Issue: 99, P. 101302 - 101302
Published: Aug. 1, 2024
Modern methods of molecular diagnostics and therapy have revolutionized the field medicine in recent years by providing more precise effective tools for detecting treating diseases. This progress includes a growing exploration body's secreted vesicles, known as extracellular vesicles (EVs), both diagnostic therapeutic purposes. EVs are heterogeneous population lipid bilayer almost every cell type studied so far. They detected body fluids conditioned culture media from living cells. play crucial role communication between cells organs, locally over long distances. recognized their ability to transport endogenous RNA proteins cells, including messenger (mRNA), microRNA (miRNA), misfolded neurodegenerative proteins, several other biomolecules. review explores dual utilization EVs, serving not only purposes but also platform delivering molecules tissues. Through an composition, biogenesis, selective cargo packaging, we elucidate intricate mechanisms behind via highlighting potential use applications. Finally, it addresses challenges outlines prospective directions clinical EVs.
Language: Английский
Citations
9
Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown
Published: March 24, 2025
Language: Английский
Citations
1
Vaccines, Journal Year: 2024, Volume and Issue: 12(3), P. 280 - 280
Published: March 7, 2024
Exosomes are small subtypes of extracellular vesicles (EVs) naturally released by different types cells into their environment. Their physiological roles appear to be multiple, yet many aspects biological activities remain understood. These can transport and deliver a variety cargoes may serve as unconventional secretory vesicles. Thus, they play crucial role important vectors for intercellular communication the maintenance homeostasis. Exosome production content vary under several stresses or modifications in cell microenvironment, influencing cellular responses stimulating immunity. During infectious processes, exosomes described double-edged swords, displaying both beneficial detrimental effects. Owing tractability, analysis EVs from multiple biofluids has become booming tool monitoring various pathologies, cancerous origins. In this review, we present an overview exosome features discuss particular ambiguous functions contexts. We then focus on properties diagnostic therapeutic tools. regard, explore capacity vectorize immunogenic viral antigens function mounting adaptive immune responses. As provide interesting platforms antigen presentation, further review available data engineering, which enables peptides interest exposed at surface. light all these data, emerging promising avenues vaccine strategies.
Language: Английский
Citations
7
Membranes, Journal Year: 2022, Volume and Issue: 12(12), P. 1244 - 1244
Published: Dec. 8, 2022
Extracellular vesicles (EV) are membrane surrounded by a lipid bilayer and include microvesicles, apoptotic bodies, exosomes, exomeres. Exosome-encapsulated microRNAs (miRNAs) released from cancer cells involved in the proliferation metastasis of tumor via angiogenesis. On other hand, mesenchymal stem cell (MSC) therapy, which is being employed regenerative medicine owing to ability MSCs differentiate into various cells, due humoral factors, including messenger RNA (mRNA), miRNAs, proteins, lipids, encapsulated exosomes derived transplanted cells. New treatments that advocate cell-free therapy using MSC-derived will significantly improve clinical practice. Therefore, highly purified perform their original functions desirable. In this review, we summarized advances purification, modification, application EVs as novel strategies treat some diseases.
Language: Английский
Citations
19
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Jan. 29, 2025
The immunopeptidome, a diverse set of peptides presented by Major Histocompatibility Complex (MHC) molecules, is critical component immune recognition and response. This review article delves into the mechanisms peptide presentation MHC particularly emphasizing roles ncRNA-derived extracellular vesicles (EVs) in shaping immunopeptidome landscape. We explore established emerging insights molecule interactions with peptides, including dynamics loading, transport, influence cellular genetic variations. highlights novel research on non-coding RNA (ncRNA)-derived which challenge conventional views antigen processing role EVs transporting these thereby modulating responses at remote body sites. not only challenges but also opens up new avenues for understanding responses. Furthermore, we discuss implications developing therapeutic strategies, cancer immunotherapy. By conducting comprehensive analysis current literature advanced methodologies immunopeptidomics, this aims to deepen complex interplay between system, offering perspectives potential diagnostic applications. Additionally, provide mechanism enhanced surface highlight pathway their systemic distribution, potentially altering surveillance landscapes.
Language: Английский
Citations
0
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117566 - 117566
Published: Oct. 17, 2024
Language: Английский
Citations
3
The Journal of Physiology, Journal Year: 2023, Volume and Issue: 602(11), P. 2491 - 2501
Published: Oct. 17, 2023
Cells evolved some 4 billion years ago, and since then the integrity of structural functional continuity cellular life has been maintained via highly conserved ancient processes cell reproduction division. The plasma membrane as well all cytoplasmic structures are reproduced inherited uninterruptedly by each two daughter cells resulting from every Although our understanding evolutionary emergence very first is obscured extremely long timeline that revolutionary event, generally accepted position de novo formation not possible; present products other prior cells. This essential biological principle was discovered Robert Remak effectively coined Omnis Cellula e (every cell) Rudolf Virchow: currently living have direct connections to Based on previous theoretical analysis, endowed with individual sentient cognition guides their agency, behaviour evolution. There a vital consequence this new cognitive view cells: when assemble tissue ecologies organs within multicellular organisms, including plants, animals humans, these aggregates display derivative versions aggregate tissue- organ-specific sentience consciousness. innovative evolution physiology organisms supports singular principle: organismal based extends unicellular roots.
Language: Английский
Citations
8
HORMONES, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 17, 2024
Language: Английский
Citations
2