The transmission pattern and clinical course of the first 417 patients with COVID-19 infection in Shenzhen, China DOI Creative Commons
Yi-Zi Zheng, Zhenhan Deng,

Feijuan Huang

et al.

Journal of International Medical Research, Journal Year: 2023, Volume and Issue: 51(5), P. 030006052311743 - 030006052311743

Published: May 1, 2023

To explore the transmission patterns and clinical course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that was first identified in Wuhan, China December 2019 as clustered non-clustered cases disease (COVID-19) emerged Shenzhen, China.This retrospective study included patients were confirmed by laboratory detection SARS-CoV-2 Shenzen between 19 January 2020 21 February 2020. Data on epidemiological characteristics analysed. The divided into groups. time course, intervals second COVID-19 other compared groups.The 417 (n = 235) groups 182). Compared with group, group had significantly more young (≤20 years) old (>60 patients. (nine 235; 3.83%) (three 182; 1.65%). Patients spent 4-5 days hospitalization than moderate mild disease.This analysed wave infection China.

Language: Английский

Helminth alleviates COVID-19-related cytokine storm in an IL-9-dependent way DOI Creative Commons

Zengguo Cao,

Jiaqi Wang, Xiaolei Liu

et al.

mBio, Journal Year: 2024, Volume and Issue: 15(6)

Published: May 10, 2024

ABSTRACT Hyperactivation of pro-inflammatory type 1 cytokines (e.g., tumor necrosis factor alpha [TNF-α] and interferon gamma [IFN-γ]) mirrors the inflammation coronavirus disease 2019. Helminths could alleviate excessive immune responses. Here, helminth Trichinella spiralis (Ts) infection was shown to protect against TNF-α- IFN-γ-induced shock. Mechanistically, Ts-induced protection interleukin-9 (IL-9) dependent but not IL-4Rα. Recombinant IL-9 treatment only improved survival wild-type mice with shock also that severe acute respiratory syndrome 2 (SARS-CoV-2)-infected K18-human angiotensin-converting enzyme (hACE2) mice, emphasizing significance in alleviating cytokine storm syndromes during SARS-CoV-2 infection. Interestingly, Ts excretory/secretory (TsES)-induced observed infection, indicating identifying anti-inflammatory molecules from TsES be a novel way mitigate adverse pathological pathogen IMPORTANCE Severe 2019 (COVID-19) is linked triggered by TNF-α IFN-γ syndromes, including COVID-19. , Ts) can potently activate response. we found dependent. Treatment recombinant (SARS-CoV-2) K18-hACE2 mice. Helminth (TsES) products ameliorated infection-related storm. In conclusion, our study emphasizes protecting associated Anti-inflammatory new source infections,

Language: Английский

Citations

5
SARS-CoV-2 Evolution: Implications for Diagnosis, Treatment, Vaccine Effectiveness and Development DOI Creative Commons
Fabrizio Angius,

Silvia Puxeddu,

S Zaimi

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 13(1), P. 17 - 17

Published: Dec. 28, 2024

The COVID-19 pandemic, driven by the rapid evolution of SARS-CoV-2 virus, presents ongoing challenges to global public health. is characterized rapidly evolving mutations, especially in (but not limited to) spike protein, complicating predictions about its evolutionary trajectory. These mutations have significantly affected transmissibility, immune evasion, and vaccine efficacy, leading multiple pandemic waves with over half a billion cases seven million deaths globally. Despite several strategies, from development administration design availability antivirals, including monoclonal antibodies, already having been employed, persistent circulation virus emergence new variants continue result high case numbers fatalities. In past four years, immense research efforts contributed much our understanding viral pathogenesis mechanism, syndrome, host-microbe interactions, effective vaccines, diagnostic tools, treatments. focus this review provide comprehensive analysis functional impact on diagnosis, treatments, effectiveness. We further discuss safety pregnancy implications hybrid immunity long-term protection against infection, as well latest developments pan-coronavirus nasal formulations, emphasizing need for continued surveillance, research, adaptive health strategies response race.

Language: Английский

Citations

4
Antibody responses in Omicron BF.7-infected patients vaccinated with inactivated SARS-CoV-2 DOI
Yabo Zhao, Weili Li, Liming Xu

et al.

Virology, Journal Year: 2025, Volume and Issue: 603, P. 110404 - 110404

Published: Jan. 11, 2025

Language: Английский

Citations

0
Viroporins: discovery, methods of study, and mechanisms of host-membrane permeabilization DOI
Antonio Alcaraz, José L. Nieva

Quarterly Reviews of Biophysics, Journal Year: 2025, Volume and Issue: 58

Published: Jan. 1, 2025

Abstract The ‘Viroporin’ family comprises a number of mostly small-sized, integral membrane proteins encoded by animal and plant viruses. Despite their sequence structural diversity, viroporins share common functional trend: capacity to assemble transmembrane channels during the replication cycle virus. Their selectivity spectrum ranges from low-pH-activated, unidirectional proton transporters, size-limited permeating pores allowing passive diffusion metabolites. Through mechanisms not fully understood, expression facilitates virion assembly/release infected cells, subverts cell physiology, contributing cytopathogenicity. Compounds that interact with interfere membrane-permeabilizing activity in vitro , are known inhibit virus production. Moreover, viroporin-defective viruses comprise source live attenuated vaccines prevent infection notorious human livestock pathogens. This review dives into origin evolution viroporin concept, summarizes some methodologies used characterize structure–function relationships these important virulence factors, attempts classify them on biophysical grounds attending ion/solute transport across membranes.

Language: Английский

Citations

0
The relationship between selenium and viral diseases DOI Creative Commons
Jiali Li,

Jia Lai,

Yucheng Zeng

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Abstract Selenium (Se) is a trace element that fulfills vital functions in the organism. Over past few years, numerous studies have revealed profound connection between and its therapeutic potential addressing various viral infectious diseases. can boost activity of immune cells counteract oxidative damage caused by free radicals to prevent replication viruses. Studies shown protects against wide range viruses such as DNA viruses, hepatitis B virus, RNA human immunodeficiency virus coxsackie virus. probably one research directions for antiviral drugs future. This review summarizes use therapy progress.

Language: Английский

Citations

0
Evaluation of the gene expression of CD27 and CD73, and the anti-SARS-CoV-2 Spike IgG level before and after receiving the inactivated SARS-COV-2 vaccine DOI

Ali Mostafaei,

Mojtaba Jafarinia, Mohammad Kargar

et al.

Gene Reports, Journal Year: 2025, Volume and Issue: unknown, P. 102196 - 102196

Published: March 1, 2025

Language: Английский

Citations

0
Persistent Nucleic Acids from Endemic Human Coronaviruses in Adenoids: Do They Enhance Children's Immune Response to SARS-CoV-2 Infection? DOI Creative Commons

Kai Winkler,

Lucia Otten,

Alina Abramian

et al.

Journal of Clinical Virology Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100208 - 100208

Published: March 1, 2025

Language: Английский

Citations

0
Morbidity of viral vaccine preventable diseases in the Mexican states bordering the U.S., 2014–2023 DOI

Eriko Padron-Regalado,

Nicole A. Escudero González,

Hilda Nereyda Del Carmen Selvera

et al.

Vaccine, Journal Year: 2025, Volume and Issue: 56, P. 127192 - 127192

Published: May 1, 2025

Language: Английский

Citations

0
Advances in COVID-19 Therapeutics: Exploring the Role of Lectins and Protease Inhibitors DOI

Lucas Gabriel Pita dos Santos,

Gabriel da Silva Coutinho,

Júlia Maria Rodrigues Guimarães

et al.

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107687 - 107687

Published: May 1, 2025

Language: Английский

Citations

0
Effectiveness of vaccination against SARS-CoV-2 and the need for alternative preventative approaches in immunocompromised individuals: a narrative review of systematic reviews DOI Creative Commons
Thuan Tong Tan,

Heng Joo Ng,

Barnaby Edward Young

et al.

Expert Review of Vaccines, Journal Year: 2023, Volume and Issue: 22(1), P. 341 - 365

Published: March 15, 2023

Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including administration of booster doses, continues to be the most effective method for controlling COVID-19-related complications progression illness and death. However, there is mounting evidence that more needs done protect individuals with compromised immune function.Here, we review effectiveness COVID-19 vaccination in immunocompromised patients, those primary immunodeficiencies, HIV, cancer (including hematological malignancies), solid organ transplant recipients, chronic kidney disease, as reported systematic reviews/meta-analyses published over a 12-month period PubMed. Given varied responses patients function, major goal this analysis was try identify specific risk-factors related vaccine failure.COVID-19 remains global problem, new variants concern emerging at regular intervals. There an ongoing need optimal strategies combat pandemic. In addition, alternative treatment approaches are needed who may not mount adequate response current vaccines. Identification high-risk introduction newer antiviral such monoclonal antibodies will offer physicians therapeutic options vulnerable individuals.

Language: Английский

Citations

6