Importance of GC-MS for Analyzing Sars-Cov-2 Drugs in Biological Sample DOI

Mutawaqila Juveria Fatima,

C. Parthiban

Asian Journal of Research in Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 296 - 300

Published: Oct. 31, 2024

The advent way of the SARS-CoV-2 virus has put a lot pressure on actual developing drugs and diagnostics. Gas Chromatography-Mass Spectrometry (GC-MS) is rapidly becoming one most valuable techniques in detecting identifying related to COVID-19 biological samples. This method integrates separation capabilities gas chromatography with identification power mass spectrometry, enabling analysis volatile semi-volatile compounds. Through GC-MS, researchers can identify trace elements complex matrices, such as serum, urine, exhaled breath, which crucial for monitoring drug concentrations understanding pharmacokinetics. Notably, GC-MS been instrumental antiviral like chloroquine hydroxychloroquine, well biomarkers associated infection. application extends beyond analysis; it also plays significant role early diagnosis by analyzing breath samples specific metabolites linked SARS-CoV-2. paper discusses importance research, highlighting its applications detection, diagnosis, public health management.

Language: Английский

SARS-CoV-2 Evolution: Implications for Diagnosis, Treatment, Vaccine Effectiveness and Development DOI Creative Commons
Fabrizio Angius,

Silvia Puxeddu,

S Zaimi

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 13(1), P. 17 - 17

Published: Dec. 28, 2024

The COVID-19 pandemic, driven by the rapid evolution of SARS-CoV-2 virus, presents ongoing challenges to global public health. is characterized rapidly evolving mutations, especially in (but not limited to) spike protein, complicating predictions about its evolutionary trajectory. These mutations have significantly affected transmissibility, immune evasion, and vaccine efficacy, leading multiple pandemic waves with over half a billion cases seven million deaths globally. Despite several strategies, from development administration design availability antivirals, including monoclonal antibodies, already having been employed, persistent circulation virus emergence new variants continue result high case numbers fatalities. In past four years, immense research efforts contributed much our understanding viral pathogenesis mechanism, syndrome, host-microbe interactions, effective vaccines, diagnostic tools, treatments. focus this review provide comprehensive analysis functional impact on diagnosis, treatments, effectiveness. We further discuss safety pregnancy implications hybrid immunity long-term protection against infection, as well latest developments pan-coronavirus nasal formulations, emphasizing need for continued surveillance, research, adaptive health strategies response race.

Language: Английский

Citations

3
The potential of circulating microRNAs as novel diagnostic biomarkers of COVID-19: a systematic review and meta-analysis DOI Creative Commons
Melaku Ashagrie Belete, Denekew Tenaw Anley, Sintayehu Simie Tsega

et al.

BMC Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 19, 2024

Language: Английский

Citations

2
Parenteral vaccine delivery DOI
Keshava Jetha, Niva Rani Gogoi, Anup Kumar

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 167 - 205

Published: Jan. 1, 2024

Language: Английский

Citations

1
History of vaccination DOI
Vivek P. Chavda, Pankti C. Balar, Vasso Apostolopoulos

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 12

Published: Jan. 1, 2024

Language: Английский

Citations

1
Applications of Artificial Intelligence in Pharmaceutical Research: An Extensive Review DOI Open Access

G Nihalani

Bioequivalence & Bioavailability International Journal, Journal Year: 2024, Volume and Issue: 8(1), P. 1 - 7

Published: Feb. 15, 2024

Artificial Intelligence (AI) is transforming the pharmaceutical industry, revolutionizing drug discovery, development, and patient care. This comprehensive review explores diverse applications of AI in sector, discussing its advantages, challenges, future prospects. AI-driven techniques, including machine learning deep learning, have accelerated discovery processes by expediting target identification, virtual screening, repurposing. Predictive analytics optimize clinical trial design, while personalized medicine leverages patient-specific data for precise treatment plans. enhances formulation manufacturing, improves pharmacovigilance safety, supports pricing market access strategies. Despite potential, challenges such as ethical considerations privacy concerns must be addressed. The integration into existing workflows regulatory compliance remain areas focus. By overcoming these stands poised to reshape industry pave way a more efficient, personalized, impactful approach development healthcare.

Language: Английский

Citations

1
Comparative Analysis of QCM and Electrochemical Aptasensors for SARS-CoV-2 Detection DOI Creative Commons
Katarína Nemčeková,

Jana Korčeková,

Veronika Svitková

et al.

Biosensors, Journal Year: 2024, Volume and Issue: 14(9), P. 431 - 431

Published: Sept. 6, 2024

The rapid and accurate detection of SARS-CoV-2, particularly its spike receptor-binding domain (S-RBD), was crucial for managing the COVID-19 pandemic. This study presents development optimization two types aptasensors: quartz crystal microbalance (QCM) electrochemical sensors, both employing thiol-modified DNA aptamers S-RBD detection. QCM aptasensor demonstrated exceptional sensitivity, achieved by optimizing aptamer concentration, buffer composition, pre-treatment conditions, with a limit (LOD) 0.07 pg/mL linear range from 1 to 0.1 µg/mL, significant frequency change observed upon target binding. aptasensor, designed efficient preparation, utilized one-step modification process that reduced preparation time 2 h while maintaining high sensitivity specificity. Electrochemical impedance spectroscopy (EIS) enabled concentrations as low 132 ng/mL. Both sensors exhibited specificity, negligible non-specific interactions in presence competing proteins. Additionally, aptasensor's functionality stability were verified biological fluids, indicating potential real-world applications. highlights comparative advantages aptasensors terms time, offering valuable insights rapid, sensitive, specific diagnostic tools SARS-CoV-2 other viruses.

Language: Английский

Citations

1
Advancing SARS‐CoV‐2 Variant Detection with High Affinity Monoclonal Antibodies and Plasmonic Nanostructure DOI Creative Commons

Jea Sung Ryu,

Soo Hyun Lee, Hye-Ran Kim

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 16, 2024

Abstract A nanoplasmonic biosensor for the precise detection of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) by leveraging advances in nanostructured sensing materials and highly selective monoclonal antibodies is presented. The sensor integrates plasmonic Au nanostructures optimized surface‐enhanced Raman scattering (SERS), enhancing sensitivity through unique light interactions at nanoscale. Coupled with exclusive that specifically target SARS‐CoV‐2 its evolving variants, this demonstrates remarkable selectivity versatility. Validated 270 clinical samples, it a 98.9% specificity 100%. More importantly, virus nasopharyngeal swab samples collected over 3 years, marking long‐term, large‐scale validation been successfully detected. Furthermore, integration face masks enables airborne SARS‐CoV‐2, highlighting potential routine management disease 2019 (COVID‐19).

Language: Английский

Citations

1
Oral Vaccine Delivery DOI
Pankti C. Balar,

Vidhi A. Modh,

Sanjay Chauhan

et al.

Published: Feb. 16, 2024

Vaccines are preparations of dead or weakened pathogens, such as bacteria viruses, that, when administered, induce the formation antibodies cellular protection against pathogen. Thanks to innovative biotechnology techniques used in both initial and final analyses these products, successful currently rapid advancement various vaccine types monoprophylaxis through mass vaccination have proven be a approach control viral infections. In contrast conventional medications, which may an overall negative effect on body, nanovaccines vaccinations made nanoparticles (NPs) rapidly developing entirely novel category vaccines that specifically target spot body where sickness infection began. Due same nanoscale sizes pathogens materials, body's immune system responds stimuli appropriately, resulting favorable humoral responses system. To address many challenges manufacturing, targeted dispersion NPs produces long-term release together with enhanced stability antibody response. get beyond physiological immunological barriers protect internal environment from outside substances, oral is necessary. This chapter's emphasis employed delivery.

Language: Английский

Citations

0
Nanotechnology and Vaccine Development DOI
Keshava Jetha, Praful D. Bharadia, Manish P. Patel

et al.

Published: Feb. 16, 2024

Nanotechnology-based vaccines are a promising area of research that offers numerous advantages over traditional vaccines. They have the potential to provide enhanced immunogenicity, reduced side effects, improved stability, and multifunctional capabilities. Nanoparticle can be administered through various routes, including intramuscular injection, subcutaneous intradermal oral delivery, nasal topical application. However, large-scale manufacturing uniformity in regulatory guidelines major challenges associated with nanoparticle-based needs addressed. Despite these challenges, development nanotechnology-based an exciting opportunity improve vaccine efficacy accessibility.

Language: Английский

Citations

0
Automation Techniques in Clinical Virology DOI

Shreya Yadav,

Meraj A. Khan,

Jyoti Bala

et al.

Published: Jan. 1, 2024

By providing quick and precise viral infection detection, diagnosis, characterization, automation has transformed the field of virology. Virologists have been able to automate a number laboratory activities, including sample collection, processing, analysis, result interpretation, using combination Biotechnology, Artificial Intelligence (AI), Omics technology. Real-time monitoring infections made possible by advance devices aptasensors, biosensors, microfluidics, lab-on-a-chip technologies. This provided important insights into pathogenesis epidemiology. Rapid detection classification new strains efficient accurate analysis enormous volumes genomic data AI algorithms. High-throughput examination genetic material omics technologies, such as genomics, transcriptomics, proteomics. contributed in discovery therapy targets development antiviral medicines. With advancement technologies like CRISPR-Cas9 gene editing machine learning algorithms for outbreak prediction, virology huge amount potential future. The these hasten creation virus-specific treatments vaccinations.

Language: Английский

Citations

0