Luteolin: A promising multifunctional natural flavonoid for human diseases

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(7), P. 3417 - 3443

Published: April 26, 2024

Abstract Natural products are closely associated with human health. Luteolin (LUT), a flavonoid polyphenolic compound, is widely found in fruits, vegetables, flowers, and herbs. It noteworthy that LUT exhibits variety of beneficial pharmacological properties holds significant potential for clinical applications, particularly antitumor, anti‐convulsion, diabetes control, anti‐inflammatory, neuroprotection, anti‐oxidation, anti‐cardiovascular, other aspects. The mechanism action has been partially elucidated, including the mediation NF‐κB, toll‐like receptor, MAPK, Wnt/β‐catenin, PI3K/Akt, AMPK/mTOR, Nrf‐2, among others. review aimed to comprehensively consolidate essential information on natural sources, effects, therapeutic preventive potential, as well mechanisms LUT. objective establish theoretical basis continued development application

Language: Английский

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Revisiting luteolin: An updated review on its anticancer potential

Heliyon, Journal Year: 2024, Volume and Issue: 10(5), P. e26701 - e26701

Published: Feb. 20, 2024

Numerous natural products found in our diet, such as polyphenols and flavonoids, can prevent the progression of cancer. Luteolin, a flavone, present significant amounts various fruits vegetables plays key role chemopreventive agent treating types By inducing apoptosis, initiating cell cycle arrest, decreasing angiogenesis, metastasis, proliferation, luteolin is used to treat Its anticancer properties are attributed its capability engage with multiple molecular targeted sites modify signaling pathways tumor cells. Luteolin has been shown slow spread cancer breast, colorectal, lung, prostate, liver, skin, pancreatic, oral, gastric models. It exhibits antioxidant be given patients receiving Doxorubicin (DOX) chemotherapy development unexpected adverse reactions lungs hematopoietic system subjected DOX. Furthermore, it could an excellent candidate for synergistic studies overcome drug resistance Accordingly, this review covers recent literature related use against different cancer, along mechanisms action. In addition, highlights complementary medicine preventing

Language: Английский

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Therapeutic Potential of Polyphenols and Other Micronutrients of Marine Origin

Marine Drugs, Journal Year: 2023, Volume and Issue: 21(6), P. 323 - 323

Published: May 26, 2023

Polyphenols are compounds found in various plants and foods, known for their antioxidant anti-inflammatory properties. Recently, researchers have been exploring the therapeutic potential of marine polyphenols other minor nutrients that algae, fish crustaceans. These unique chemical structures exhibit diverse biological properties, including anti-inflammatory, antioxidant, antimicrobial antitumor action. Due to these being investigated as possible agents treatment a wide variety conditions, such cardiovascular disease, diabetes, neurodegenerative diseases cancer. This review focuses on applications human health, also, phenolic classes, extraction methods, purification techniques future compounds.

Language: Английский

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Luteolin, a flavone ingredient: Anticancer mechanisms, combined medication strategy, pharmacokinetics, clinical trials, and pharmaceutical researches

Phytotherapy Research, Journal Year: 2023, Volume and Issue: 38(2), P. 880 - 911

Published: Dec. 13, 2023

Abstract Current pharmaceutical research is energetically excavating the pharmacotherapeutic role of herb‐derived ingredients in multiple malignancies’ targeting. Luteolin one major phytochemical components that exist various traditional Chinese medicine or medical herbs. Mounting evidence reveals this phytoconstituent endows prominent therapeutic actions on diverse malignancies, with underlying mechanisms, combined medication strategy, and pharmacokinetics elusive. Additionally, clinical trial investigation luteolin remain to be systematically delineated. The present review aimed comprehensively summarize updated information regard anticancer mechanism, strategies, pharmacokinetics, trials, researches luteolin. survey corroborates executes effects mainly by dampening proliferation invasion, spurring apoptosis, intercepting cell cycle, regulating autophagy immune, inhibiting inflammatory response, inducing ferroptosis, pyroptosis, as well epigenetic modification, so on. can applied combination numerous anticarcinogens natural synergistically enhance efficacy malignancies while reducing adverse reactions. For has an unfavorable oral bioavailability, it persists plasma glucuronides sulfate‐conjugates after being metabolized, regarded potent inhibitors OATP1B1 OATP2B1, which may messed pharmacokinetic interactions miscellaneous bioactive substances vivo. Besides, innovation leading‐edge drug delivery systems such host–guest complexes, nanoparticles, liposomes, nanoemulsion, microspheres, hydrogels are beneficial exploitation luteolin‐based products. Moreover, some registered trials carried out, yet should continuously promoted.

Language: Английский

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Application of Luteolin in Neoplasms and Nonneoplastic Diseases

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(21), P. 15995 - 15995

Published: Nov. 6, 2023

Researchers are amazed at the multitude of biological effects 3′,4′,5,7-tetrahydroxyflavone, more commonly known as luteolin, it simultaneously has antioxidant and pro-oxidant, well antimicrobial, anti-inflammatory, cancer-preventive, properties. The anticancer properties luteolin constitute a mosaic pathways due to which this flavonoid influences cancer cells. Not only is able induce apoptosis inhibit cell proliferation, but also suppresses angiogenesis metastasis. Moreover, succeeds in sensitization therapeutically induced cytotoxicity. Nevertheless, apart from its promising role chemoprevention, exhibits numerous potential utilizations patients with conditions other than neoplasms, include inflammatory skin diseases, diabetes mellitus, COVID-19. This review aims present multidimensionality luteolin’s impact on both neoplastic nonneoplastic diseases. When comes we intend describe complexity molecular mechanisms that underlay effectiveness, prove usefulness integrating therapy via analysis recent research breast, colon, lung cancer. Regarding emphasize importance researching areas such diabetology, virology, dermatology summarizes most important discoveries those fields regarding application.

Language: Английский

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Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116909 - 116909

Published: June 8, 2024

Lung cancer is a prevalent malignant tumor and leading cause of cancer-related fatalities globally. However, current treatments all have limitations. Therefore, there an urgent need to identify readily available therapeutic agent counteract lung development progression. Luteolin flavonoid derived from vegetables herbs that possesses preventive effects on various cancers. With the goal providing new directions for treatment cancer, we review here recent findings luteolin so as provide ideas anti-lung drugs. The search focused studies published between January 1995 2024 explored use in cancer. A comprehensive literature was conducted SCOPUS, Google Scholar, PubMed, Web Science databases using keywords "luteolin" "lung cancer." By collecting previous literature, found has multiple mechanisms effects, including promotion apoptosis cells; inhibition cell proliferation, invasion metastasis; modulation immune responses. In addition, it can be used adjuvant radio-chemotherapy helps ameliorate complications. This summarizes structure, natural sources, physicochemical properties pharmacokinetics luteolin, focuses mechanism

Language: Английский

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The Emerging Role of Natural Products in Cancer Treatment

Archives of Toxicology, Journal Year: 2024, Volume and Issue: 98(8), P. 2353 - 2391

Published: May 25, 2024

Language: Английский

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Luteolin: exploring its therapeutic potential and molecular mechanisms in pulmonary diseases

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 12, 2025

Luteolin is a flavonoid widely found in plants, including vegetables, botanical drugs, and fruits. Owing to its diverse pharmacological activities, such as anticancer, oxidative stress protection, anti-inflammatory, neuron-preserving effects, luteolin has attracted attention research medicine. exhibits therapeutic effects on various pulmonary disease models through multiple molecular mechanisms; these include inhibition of activation the PI3K/Akt-mediated Nuclear Factor kappa-B (NF-κB) MAPK signaling pathways, well promotion regulatory T cell (Treg) function enhancement alveolar epithelial sodium channel (ENaC) activity (alleviating inflammation responses). chronic obstructive (COPD), acute lung injury/acute respiratory distress syndrome (ALI/ARDS), fibrosis, allergic asthma, cancer. Luteolin, naturally occurring polyphenol, poorly water-soluble. The oral route may be ineffective because gut absorbs this type flavonoid. Therefore, although significant biological activity, clinical application limited by challenges associated with poor water solubility low bioavailability, which are critical factors for efficacy application. These can addressed modifying chemical structure enhancing pharmaceutical formulations. We summarized advancements improving bioavailability luteolin, diseases their related mechanisms, aim providing new ideas researchers.

Language: Английский

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Exploiting Nanotechnology for Drug Delivery: Advancing the Anti-Cancer Effects of Autophagy-Modulating Compounds in Traditional Chinese Medicine

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 2507 - 2528

Published: March 1, 2024

Background: Cancer continues to be a prominent issue in the field of medicine, as demonstrated by recent studies emphasizing significant role autophagy development cancer. Traditional Chinese Medicine (TCM) provides variety anti-tumor agents capable regulating autophagy. However, clinical application autophagy-modulating compounds derived from TCM is impeded their restricted water solubility and bioavailability. To overcome this challenge, utilization nanotechnology has been suggested potential solution. Nonetheless, current body literature on nanoparticles delivering TCM-derived for cancer treatment limited, lacking comprehensive summaries detailed descriptions. Methods: Up November 2023, research study was conducted gather relevant data using databases, including PubMed, ScienceDirect, Springer Link, Web Science, CNKI. The keywords utilized investigation included "autophagy", "nanoparticles", "traditional medicine" "anticancer". Results: This review analysis overcoming delivery challenges enhancing anti-cancer properties TCM. evaluation based synthesis different classes TCM, mechanisms action treatment, benefits reported various scholarly sources. findings indicate that shows availability thereby opening up plethora therapeutic avenues. Conclusion: Nanotechnology enhance efficacy traditional through regulation Keywords: autophagy, nano-delivery, anti-cancer, medicine

Language: Английский

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Potential Strategies for Overcoming Drug Resistance Pathways Using Propolis and Its Polyphenolic/Flavonoid Compounds in Combination with Chemotherapy and Radiotherapy

Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3741 - 3741

Published: Oct. 31, 2024

Conventional cancer treatments include surgical resection, chemotherapy, hyperthermia, immunotherapy, hormone therapy, and locally targeted therapies such as radiation therapy. Standard often require the use of multiple agents, which can activate nuclear factor kappa B (NF-κB) in tumor cells, leading to reduced cell death increased drug resistance. Moreover, agents also contributes added toxicity, resulting poor treatment outcomes. Cancer cells gradually develop resistance almost all chemotherapeutics through various mechanisms, efflux, alterations metabolism transport, changes signal transduction pathways, enhanced DNA repair capacity, evasion apoptosis, mutations, reactivation targets, interaction with microenvironment, cell-stroma interactions, epithelial–mesenchymal transition (EMT)-mediated chemoresistance, epigenetic modifications, metabolic alterations, effect stem (CSCs). Developing new strategies improve chemotherapy sensitivity while minimizing side effects is essential for achieving better therapeutic outcomes enhancing patients’ quality life. One promising approach involves combining conventional propolis its flavonoids. These natural compounds may enhance response reducing toxicity. Propolis components sensitize chemotherapeutic likely by inhibiting NF-κB activation, reprogramming tumor-associated macrophages (TAMs; an M2-like phenotype), thereby release matrix metalloproteinase (MMP)-9, cytokines, chemokines, vascular endothelial growth (VEGF). By TAMs, overcome EMT-mediated disrupt crosstalk between CSCs, inhibit maintenance stemness, reverse acquired immunosuppression, thus promoting antitumor mediated cytotoxic T-cells. This review highlights potential flavonoids modulate responsiveness modalities. The evidence suggests that novel incorporating could be developed positive cytotoxicity peripheral blood leukocytes, liver, kidney cells. Therefore, polyphenolic/flavonoid hold combination clinical types cancers.

Language: Английский

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