Effectiveness of drug repurposing approach against Candida isolates DOI Creative Commons

Ayesha Ansari,

Mandeep Kaur Saini,

Darshan Kumar

et al.

Environment Conservation Journal, Journal Year: 2024, Volume and Issue: 25(4), P. 1030 - 1044

Published: Sept. 15, 2024

Over the past three decades, there has been an increase in severity of fungal infections, affecting several individuals and claiming lives more than 1.6 million people every year. Species Candida are one causatives invasive extensive use antifungals for their treatment led to emergence drug resistance these species, highlighting need exploration effective cost-effective therapeutics. Drug repurposing is important solution alternative There many studies where antifungal indications any existing have analyzed with aim establish new antimycotic therapeutics a short time lower budget. In this review, efforts made compile literature on repurposed drugs against clinical isolates pathogens better illustrate repurposing's role candidiasis.

Language: Английский

Cell Membrane‐Coated Nanoparticles: A New Frontier in Immunomodulation DOI Creative Commons
Nimeet Desai, Vishakha Tambe, Prasad Pofali

et al.

Advanced NanoBiomed Research, Journal Year: 2024, Volume and Issue: 4(8)

Published: May 31, 2024

Immune dysregulation is a pivotal factor in the onset and progression of various diseases. In cancer, immune system's inability to discern eliminate abnormal cells leads uncontrolled tumor growth. When faced with resilient pathogens or harmful toxins, system encounters challenges clearance neutralization. Achieving delicate balance pro‐inflammatory anti‐inflammatory signals essential managing range disorders Like other biomedical research domains, nanotechnology has provided innovative approaches for rebalancing host immunity. Among plethora nanotechnology‐based interventions, concept cell membrane‐coated nanoparticles holds significant potential immunomodulatory applications owing their biomimetic properties that allow precise interaction compromised system. This review thoroughly examines novel nanosystems modulation. The exploration covers crucial elements, including origins characteristics membranes, methods employed procurement coating, physicochemical/biological characterization techniques, enhancement therapeutic efficacy via functionalization. Subsequently, case studies‐based analysis utilizing these bioinspired tackling different conditions caused by disturbance been comprehensively discussed.

Language: Английский

Citations

10
Plant-Derived Exosomes in Therapeutic Nanomedicine, Paving the Path Toward Precision Medicine DOI
Min Zheng, Vivek P. Chavda, Dixa A. Vaghela

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156087 - 156087

Published: Sept. 26, 2024

Language: Английский

Citations

5
Fungal Pulmonary Coinfections in COVID-19: Microbiological Assessment, Inflammatory Profiles, and Clinical Outcomes DOI Creative Commons

Petrinela Daliu,

Iulia Bogdan, Ovidiu Roșca

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 864 - 864

Published: April 3, 2025

Background and Objectives: Secondary pulmonary fungal infections in coronavirus disease 2019 (COVID-19) remain underexplored despite emerging reports linking them to heightened morbidity. Comorbidities, steroid use, prolonged hospital stays can predispose patients opportunistic fungi. This study aimed evaluate the impact of coinfection on inflammatory markers, severity, antifungal resistance profiles, outcomes hospitalized COVID-19 patients. Methods: retrospective observational enrolled 280 adults (≥18 years) with real-time polymerase chain reaction (RT-PCR)-confirmed admitted a tertiary care center (January 2023–December 2024). Patients were divided into COVID-19-only group (n = 216) COVID–fungal 64) based bronchoalveolar lavage, sputum, and/or blood culture positivity for pathogens. Inflammatory markers (C-reactive protein (CRP), procalcitonin, neutrophil-to-lymphocyte ratio, systemic immune inflammation index) severity scores (Acute Physiology Chronic Health Evaluation II, CURB-65 score, National Early Warning Score) measured. We assessed susceptibilities recorded ICU admissions, ventilation, length stay, mortality. Results: Aspergillus fumigatus (31.3%), Candida albicans (28.1%), Cryptococcus neoformans (7.8%), Pneumocystis jirovecii (6.3%), Mucorales (6.3%) dominated; glabrata, tropicalis, mixed also noted. Multidrug-resistant (MDR) isolates or triazoles occurred 25.0% cultures. The COVID-19–fungal showed significantly higher CRP (85.7 vs. 71.6 mg/L, p < 0.001), procalcitonin (2.4 1.3 ng/mL, APACHE II (18.6 14.8, 0.001). intensive-care unit admissions (39.1% 19.9%, 0.004) mechanical ventilation (26.6% 10.2%, 0.01) more frequent coinfection. Mortality trended at rate (15.6% 7.4%, 0.06). Conclusions: Pulmonary coinfections intensify milieu, elevate scores, lead ICU-level interventions identification, guided by culture-based molecular diagnostics, alongside prompt therapy, could mitigate adverse outcomes. These findings underscore critical need proactive surveillance rigorous stewardship managing severe pneumonia.

Language: Английский

Citations

0
Regulatory Guidelines for Vaccine Adjuvants DOI
Suneetha Vuppu, Vivek P. Chavda, Toshika Mishra

et al.

Published: April 21, 2025

Citations

0
Use of Hand Sanitizers in COVID-19 Prevention: A Comprehensive Overview DOI Creative Commons
Suneetha Vuppu, Toshika Mishra,

Arjun Chinamgari

et al.

Pharmacoepidemiology, Journal Year: 2023, Volume and Issue: 2(3), P. 257 - 271

Published: Aug. 1, 2023

The pandemic outbreak of Coronavirus disease 2019 (COVID-19) has drastically changed the picture global healthcare. With rapid emergence novel variants severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that rendered currently available therapeutic and diagnostic approaches inefficient in containing transmission infection, it becomes important to focus on strategies break chain. major approach contain spread infection is promotion adequate hand hygiene practices public as hands are an source pathogenic microbes. Hand part everyday life for maintaining a healthy disease-free lifestyle. pandemic, people now understanding importance practices. market sanitizers experienced growth high demand. This review aims discuss use during period COVID-19 their role controlling infection. It also focuses trends, advancements development sanitizer formulations, limitations commercial sanitizers. Therefore, formulation effective disinfectant crucial preventing future outbreaks.

Language: Английский

Citations

7
Identification and characterization of a novel antifungal compound tubeimoside I targeting cell wall DOI Creative Commons

Qiannan Liu,

Zhiqi Zhong,

Shunxin Zheng

et al.

Microbiology Spectrum, Journal Year: 2024, Volume and Issue: 12(6)

Published: April 23, 2024

Due to fungal diseases that threaten immunocompromised patients, along with the limited availability of antifungal agents, there is an urgent need for new compounds treat infections. Here, we aimed identify potential drugs from natural products using fission yeast

Language: Английский

Citations

2
Increased Fungal Infection Mortality Induced by Concurrent Viral Cellular Manipulations DOI
Kevin Roe

Lung, Journal Year: 2023, Volume and Issue: 201(5), P. 467 - 476

Published: Sept. 5, 2023

Language: Английский

Citations

6
Synergy and Mechanism of Leflunomide Plus Fluconazole Against Resistant Candida albicans: An in vitro Study DOI Creative Commons
Xiuyun Li, Ning Zhang, Liuping Zhang

et al.

Infection and Drug Resistance, Journal Year: 2023, Volume and Issue: Volume 16, P. 4147 - 4158

Published: June 1, 2023

The global rise in the resistance of Candida albicans to conventional antifungals makes infections harder treat. main objective this study was investigate antifungal effects and underlying mechanisms leflunomide combination with triazoles against resistant albicans.In study, microdilution method used determine three on planktonic cells vitro. morphological transition from yeast hyphae observed under a microscope. ROS, metacaspase, efflux pumps, intracellular calcium concentration were investigated, respectively.Our findings suggested that + showed synergistic effect Further concluded resulted multiple factors, including inhibited triazoles, inhibition yeast-to-hyphae transition, ROS increasing, metacaspase activation, [Ca2+]i disturbance.Leflunomide appears be potential enhancer current agents for treating candidiasis caused by albicans. This can also serve as an example inspire exploration new approaches

Language: Английский

Citations

4
History of vaccination DOI
Vivek P. Chavda, Pankti C. Balar, Vasso Apostolopoulos

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 12

Published: Jan. 1, 2024

Language: Английский

Citations

1
Insights on Covid‐19 with superimposed pulmonary histoplasmosis: The possible nexus DOI Creative Commons
Yahya A. Almutawif, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Immunity Inflammation and Disease, Journal Year: 2023, Volume and Issue: 11(9)

Published: Sept. 1, 2023

Abstract A novel coronavirus (CoV) known as severe acute respiratory syndrome CoV type 2 is the causative agent for development of disease 2019 (Covid‐19). Covid‐19 may increase risk developing pulmonary histoplasmosis due to immune dysregulation. In addition, enhance propagation lung injury and inflammation, using corticosteroids in severely affected patients reactivate latent histoplasmosis. Likewise, activation inflammatory signaling pathways during H. capsulatum infection severity vice versa. Furthermore, lymphopenia progress besides Therefore, this critical review aimed find potential link between pneumonia concerning immunological response.

Language: Английский

Citations

2