Recent advances in mRNA cancer vaccines: meeting challenges and embracing opportunities

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 6, 2023

Since the successful application of messenger RNA (mRNA) vaccines in preventing COVID-19, researchers have been striving to develop mRNA for clinical use, including those exploited anti-tumor therapy. cancer emerged as a promising novel approach immunotherapy, offering high specificity, better efficacy, and fewer side effects compared traditional treatments. Multiple therapeutic are being evaluated preclinical trials, with early-phase results. However, development these faces various challenges, such tumor heterogeneity, an immunosuppressive microenvironment, practical obstacles like vaccine administration methods evaluation systems application. To address we highlight recent advances from studies trials that provide insight into identifying associated discuss potential strategies overcome them. In future, it is crucial caution diligence while promoting innovation existing barriers. A delicate balance between opportunities challenges will help guide progress this field towards its full potential.

Language: Английский

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Lipid Nanoparticle (LNP) Delivery Carrier-Assisted Targeted Controlled Release mRNA Vaccines in Tumor Immunity

Vaccines, Journal Year: 2024, Volume and Issue: 12(2), P. 186 - 186

Published: Feb. 12, 2024

In recent years, lipid nanoparticles (LNPs) have attracted extensive attention in tumor immunotherapy. Targeting immune cells cancer therapy has become a strategy of great research interest. mRNA vaccines are potential choice for immunotherapy, due to their ability directly encode antigen proteins and stimulate strong response. However, the mode delivery lack stability key issues limiting its application. LNPs an excellent carrier, structural biocompatibility make them effective means delivering specific targets. This study summarizes progress LNP carrier-assisted targeted controlled release immunity. The role improving stability, immunogenicity, targeting is discussed. review aims systematically summarize latest immunity provide new ideas strategies as well more treatment plans patients.

Language: Английский

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A Journey of Challenges and Victories: A Bibliometric Worldview of Nanomedicine since the 21st Century

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(15)

Published: Jan. 17, 2024

Abstract Nanotechnology profoundly affects the advancement of medicine. Limitations in diagnosing and treating cancer chronic diseases promote growth nanomedicine. However, there are very few analytical descriptive studies regarding trajectory nanomedicine, key research powers, present landscape, focal investigative points, future outlooks. Herein, articles reviews published Science Citation Index Expanded Web Core Collection from first January 2000 to 18th July 2023 analyzed. a bibliometric visualization publication trends, countries/regions, institutions, journals, categories, themes, references, keywords is produced elaborated. Nanomedicine‐related academic output increasing since COVID‐19 pandemic, solidifying uneven global distribution performance. While China leads terms quantity has numerous highly productive USA advantages impact, commercialization, industrial value. Nanomedicine integrates with other disciplines, establishing interdisciplinary platforms, which drug delivery nanoparticles remain points. Current focuses on integrating nanomedicine cell ferroptosis induction immunotherapy. The keyword “burst testing” identifies promising directions, including immunogenic death, chemodynamic therapy, tumor microenvironment, immunotherapy, extracellular vesicles. prospects, major challenges, barriers addressing these directions discussed.

Language: Английский

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Metal–Drug Coordination Nanoparticles and Hydrogels for Enhanced Delivery

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(26)

Published: April 11, 2024

Drug delivery is a key component of nanomedicine, and conventional relies on the adsorption or encapsulation drug molecules to nanomaterial. Many vehicles contain metal ions, such as metal-organic frameworks, oxides, transition dichalcogenides, MXene, noble nanoparticles. These materials have high content pose potential long-term toxicity concerns leading difficulties for clinical approval. In this review, recent developments are summarized in use ligands coordination forming various nanomaterials soft materials. these cases, drug-to-metal ratio much higher than adsorption-based strategies. The divided into small-molecule drugs, nucleic acids, proteins. formed hybrid mainly include nanoparticles hydrogels, upon which targeting can be grafted improve efficacy further decrease toxicity. application addressing cancer, viral infection, bacterial infection inflammatory bowel disease, bone diseases reviewed. end, some future directions discussed from fundamental research, science, medicine.

Language: Английский

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Boosting CAR-T cell therapy through vaccine synergy

Trends in Pharmacological Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Chimeric antigen receptor (CAR)-T cell therapy has transformed the treatment landscape for hematological cancers. However, achieving comparable success in solid tumors remains challenging. Factors contributing to these limitations include scarcity of tumor-specific antigens (TSAs), insufficient CAR-T infiltration, and immunosuppressive tumor microenvironment (TME). Vaccine-based strategies are emerging as potential approaches address challenges, enhancing expansion, persistence, antitumor efficacy. In this review, we explore diverse vaccine modalities, including mRNA, peptide, viral vector, dendritic (DC)-based vaccines, their roles augmenting responses. Special focus is given recent clinical advancements combining mRNA-based vaccines with genitourinary addition, discuss crucial considerations optimizing dosing, scheduling, delivery maximize synergy, aiming refine combination strategy improve efficacy safety.

Language: Английский

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Innovations in RNA therapeutics: a review of recent advances and emerging technologies

Nucleosides Nucleotides & Nucleic Acids, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 25

Published: Jan. 13, 2025

The field of biomedical science has witnessed another milestone with the advent RNA-based therapeutics. This review explores three major RNA molecules, namely: messenger (mRNA), interference technology (RNAi), and Antisense Oligonucleotide (ASO), analyses U.S. Food Drug Administration drugs from 14 pharmaceutical companies in terms targeted genes, diseases types, clinical trials status, mode delivery, year production. Many such are clinically approved or pending approval by (FDA) alongside other leading agencies. Regarding diseases, this article emphasizes cancer therapy, genetic viral infections, two categories drug delivery systems include vectors nanoparticles. Despite tremendous progress made, key issues associated these stability, off-target activities payloads, efficiency cellular uptake, innovative need for engineering techniques modifications. transformative potential therapeutics role technologies addressing needs, paving way a new era precision medicine.

Language: Английский

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An Overview of the Use of Nanoparticles in Vaccine Development

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(12), P. 1828 - 1828

Published: June 9, 2023

Vaccines represent one of the most significant advancements in public health since they prevented morbidity and mortality millions people every year. Conventionally, vaccine technology focused on either live attenuated or inactivated vaccines. However, application nanotechnology to development revolutionized field. Nanoparticles emerged both academia pharmaceutical industry as promising vectors develop future Regardless striking nanoparticles vaccines research variety conceptually structurally different formulations proposed, only a few them advanced clinical investigation usage clinic so far. This review covered some important developments applied technologies last years, focusing successful race for preparation lipid employed anti-SARS-CoV-2

Language: Английский

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mRNA Delivery: Challenges and Advances through Polymeric Soft Nanoparticles

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1739 - 1739

Published: Feb. 1, 2024

Single-stranded messenger ribonucleic acid (mRNA) plays a pivotal role in transferring genetic information, and tremendous effort has been devoted over the years to utilize its transcription efficacy therapeutic interventions for variety of diseases with high morbidity mortality. Lipid nanocarriers have extensively investigated mRNA delivery enabled rapid successful development vaccines against SARS-CoV-2. Some constraints lipid encouraged alternative systems, such as polymer-based soft nanoparticles, which offer modular gene platform. Such macromolecule-based can be synthetically articulated tailored parameters including protection, loading efficacy, targeted release. In this review, we highlight recent advances polymeric architectures delivery, their limitations, challenges that still exist, aim expediting further research clinical translation formulations.

Language: Английский

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Nanoparticle-Based Drug Delivery Systems in Inhaled Therapy: Improving Respiratory Medicine

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(8), P. 1059 - 1059

Published: Aug. 12, 2024

Inhaled nanoparticle (NP) therapy poses intricate challenges in clinical and pharmacodynamic realms. Recent strides have revolutionized NP technology by enabling the incorporation of diverse molecules, thus circumventing systemic clearance mechanisms enhancing drug effectiveness while mitigating side effects. Despite established success delivery oncology other disciplines, exploration inhaled therapies remains relatively nascent. NPs loaded with bronchodilators or anti-inflammatory agents exhibit promising potential for precise distribution throughout bronchial tree, offering targeted treatment respiratory diseases. This article conducts a comprehensive review applications medicine, highlighting their merits, ranging from heightened stability to exacting lung-specific delivery. It also explores cutting-edge technologies optimizing NP-loaded aerosol systems, complemented insights gleaned trials. Furthermore, examines current future prospects NP-based therapies. By synthesizing data perspectives, underscores transformative promise NP-mediated addressing chronic conditions such as obstructive pulmonary disease, pressing global health concern ranked third mortality rates. overview illuminates evolving landscape inhalation therapies, presenting optimistic avenues advancing medicine improving patient outcomes.

Language: Английский

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Combinatorial Screening of Biscarbamate Ionizable Lipids Identifies a Low Reactogenicity Lipid for Lipid Nanoparticle mRNA Delivery

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(21)

Published: Feb. 1, 2024

Abstract Messenger RNA (mRNA) has emerged as a promising therapeutic modality for various diseases. However, efficient delivery of mRNA into target cells remains significant challenge. In this study, the combinatorial synthesis and characterization novel series ionizable biscarbamate lipids (IBLs) lipid nanoparticle (LNP) are reported. A simplified scalable method is developed, resulting in IBLs suitable formulating stable LNPs. Two generations synthesized evaluated their transfection capacity vitro, using eGFP reporter protein, leading to identification S‐Ac7‐DOG lead IBL. Upon intramuscular vaccination, LNPs instigated robust antigen‐specific CD8+ T cell responses against an encoded viral oncoprotein tumor neo‐antigen. comparison MC3 LNPs, which used benchmark, exhibit low reactogenicity, transfection, distinct biodistribution, with higher accumulation draining lymph nodes spleen. These findings highlight potential class vaccines beyond.

Language: Английский

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