Approaches to Enhance the Potency of Vaccines in Chickens DOI Creative Commons

Oenone Bodman-Harris,

Christine S. Rollier, Munir Iqbal

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(12), P. 1337 - 1337

Published: Nov. 27, 2024

Outbreaks of avian pathogens such as Newcastle disease virus, influenza and salmonella have a major impact on economies food security worldwide. Some also pose significant zoonotic potential, especially viruses. Vaccination plays key role in controlling many poultry diseases, there are vaccines licenced the United Kingdom for diseases caused by viruses, bacteria, parasites. However, these often do not provide complete protection can cause unwanted side effects. Several factors affect potency vaccines, including type vaccination used, mechanism delivery, use adjuvants. Advancements technology led to study development novel vaccine adjuvants poultry. These induce stronger immune responses compared with current potential protect against multiple diseases. This review aims discuss existing technology; effect delivery mechanisms efficacy; adjuvants; ability target antigens antigen-presenting cells; probiotics, multivalent nanotechnology enhance vaccines.

Language: Английский

Progress and Challenges in HIV-1 Vaccine Research: A Comprehensive Overview DOI Creative Commons
Alex Boomgarden, Chitra Upadhyay

Vaccines, Journal Year: 2025, Volume and Issue: 13(2), P. 148 - 148

Published: Jan. 31, 2025

The development of an effective HIV-1 vaccine remains a formidable challenge in biomedical research. Despite significant advancements our understanding HIV biology and pathogenesis, progress has been impeded by factors such as the virus's genetic diversity, high mutation rates, its ability to establish latent reservoirs. Recent innovative approaches, including mosaic vaccines mRNA technology induce broadly neutralizing antibodies, have shown promise. However, efficacy these modest, with best results achieving approximately 30% effectiveness. Ongoing research emphasizes necessity multifaceted strategy overcome obstacles achieve breakthrough development. This review summarizes current approaches utilized further understand create global vaccine. We discuss impact on for other diseases, COVID-19, influenza, Zika virus. Additionally, we highlight specific limitations faced each approach present methods researchers employ challenges. These techniques, which demonstrated preclinical clinical success, advanced field closer ultimate goal developing Leveraging will enable strides combating infectious ultimately improving health outcomes.

Language: Английский

Citations

2
Next-generation treatments: Immunotherapy and advanced therapies for COVID-19 DOI Creative Commons

Jenny Andrea Arévalo-Romero,

Sandra M. Chingaté-López,

Bernardo Camacho

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(5), P. e26423 - e26423

Published: Feb. 19, 2024

The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in 2019 following prior outbreaks of coronaviruses like SARS and MERS recent decades, underscoring their high potential infectivity humans. Insights from previous have played a significant role developing effective strategies to mitigate the global impact SARS-CoV-2. As January 7, 2024, there been 774,075,242 confirmed cases worldwide. To date, 13.59 billion vaccine doses administered, 7,012,986 documented fatalities (https://www.who.int/)Despite progress addressing rapid evolution SARS-CoV-2 challenges human defenses, presenting ongoing challenges. emergence new lineages, shaped mutation recombination processes, has led successive waves infections. This scenario reveals need for next-generation vaccines as crucial requirement ensuring protection against demand calls formulations that trigger robust adaptive immune response without leading inflammation linked with infection.Key mutations detected Spike protein, critical target neutralizing antibodies design —specifically within Receptor Binding Domain region Omicron variant lineages (B.1.1.529), currently dominant worldwide, intensified concerns due association immunity evasion vaccinations infections.As world deals this evolving threat, narrative extends realm emerging variants, each displaying implications remain largely misunderstood. Notably, JN.1 lineage is gaining prevalence, early findings suggest it stands among immune-evading characteristic attributed its L455S. Moreover, detrimental consequences novel bear particularly on immunocompromised individuals older adults. Immunocompromised face such suboptimal responses vaccines, rendering them more susceptible disease. Similarly, adults an increased risk disease presence comorbid conditions, find themselves at heightened vulnerability develop Thus, recognizing these intricate factors effectively tailoring public health protect vulnerable populations. In context, review aims describe, analyze, discuss current treatments encompassing immunotherapeutic approaches advanced therapies complements will offer solutions counter disadvantages existing options. Preliminary outcomes show virus address immunomodulatory associated COVID-19. Furthermore, capacity promote tissue repair demonstrated, which can be noteworthy who stand actors landscape possess broader potential, offering wide range variants enhancing ability constant virus. are projected treatment alternatives managing Chronic Post-COVID-19 syndromeand long-term complications.

Language: Английский

Citations

10
Nanomaterials in Immunology: Bridging Innovative Approaches in Immune Modulation, Diagnostics, and Therapy DOI Creative Commons

George-Alexandru Croitoru,

Diana-Cristina Pîrvulescu,

Adelina-Gabriela Niculescu

et al.

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(8), P. 225 - 225

Published: Aug. 14, 2024

The intersection of immunology and nanotechnology has provided significant advancements in biomedical research clinical applications over the years. Immunology aims to understand immune system’s defense mechanisms against pathogens. Nanotechnology demonstrated its potential manipulate responses, as nanomaterials’ properties can be modified for desired application. Research shown that nanomaterials applied diagnostics, therapy, vaccine development. In used biosensor development, accurately detecting biomarkers even at very low concentrations. Therapeutically, act efficient carriers delivering drugs, antigens, or genetic material directly targeted cells tissues. This delivery improves therapeutic efficacy reduces adverse effects on healthy nanoparticles improve durability extend responses by effectively adjuvants antigens cells. Despite these advancements, challenges regarding safety, biocompatibility, scalability are still present. review will cover fundamental interactions between system, their immunology, safety biocompatibility concerns.

Language: Английский

Citations

9
Nanostructured Drug Delivery Systems in Immunotherapy: An Updated Overview of Nanotechnology-Based Therapeutic Innovations DOI Creative Commons

George-Alexandru Croitoru,

Adelina-Gabriela Niculescu,

Dragoș Epistatu

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(19), P. 8948 - 8948

Published: Oct. 4, 2024

Using nanostructured drug delivery systems has attracted increasing interest in immunotherapeutic approaches. The intrinsic immunomodulatory properties and versatility of nanoparticles used as carriers were consistently reported to augment treatment efficiency nanoscaled materials increase accumulation at the desired site, enhance cell internalization, improve therapeutic outcomes. Thus, numerous studies have exploited potential use vehicles delivering different cargo a promising alternative for treating conditions like cancer, autoimmune diseases, infectious allergic immune disorders. In this context, paper presents solid basis innovations, highlighting their advantages improving strategies, reviewing clinical applications, discussing existing challenges ways overcome them.

Language: Английский

Citations

9
Nanomedicinas: una alternativa terapéutica en desarrollo para el control de las crisis epilépticas DOI Creative Commons
Argelia Rosillo-de la Torre, Laura E. Castellano, David Alcántara-González

et al.

eNeurobiología, Journal Year: 2025, Volume and Issue: 16(40)

Published: Jan. 16, 2025

La nanomedicina es el nombre que se asigna a las tecnologías nanométricas aplicadas al cuidado de la salud, cuales han permitido desarrollo estrategias innovadoras para tratamiento y diagnóstico diversas enfermedades, incluidas aquellas afectan sistema nervioso central. En particular, debido ventajas conferidas por sus características intrínsecas, nanomedicinas explorado como una posible alternativa terapéutica permita optimizar control crisis epilépticas epilepsia través diversos enfoques, pueden incluir mejorar farmacocinética los fármacos anticrisis, reducir efectos adversos, aumentar su eficacia y, en algunos casos, superar farmacorresistencia. Estas posicionan herramienta muy atractiva ayude desafíos imposibilitado óptimo ciertos casos particulares, Esta revisión aborda aspectos generales sobre epilepsia, proporcionando un contexto fisiopatología asociados con tratamientos esta enfermedad. Además, recopilan evidencias evaluado uso potencial diferentes modelos animales agudas, así responsiva refractaria tratamiento, desde enfoque ciencia básica. Estos estudios proporcionan evidencia fundamental, ámbito medicina traslacional, sienta bases futuras aplicaciones trasladarse eventualmente práctica clínica trastornos epilépticos.

Citations

1
Mast cell activators as adjuvants for intranasal mucosal vaccines DOI

Cheryl Murphy,

Eric M. Bachelder, Kristy M. Ainslie

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 672, P. 125300 - 125300

Published: Feb. 4, 2025

Language: Английский

Citations

1
Next-Generation Vaccine Development with Nanomaterials: Recent Advances, Possibilities, and Challenges DOI
Shamitha Shetty, Pablo Cordero Alvarado, Deleah Pettie

et al.

Annual Review of Biomedical Engineering, Journal Year: 2024, Volume and Issue: 26(1), P. 273 - 306

Published: July 3, 2024

Nanomaterials are becoming important tools for vaccine development owing to their tunable and adaptable nature. Unique properties of nanomaterials afford opportunities modulate trafficking through various tissues, complement or augment adjuvant activities, specify antigen valency display. This versatility has enabled recent work designing nanomaterial vaccines a broad range diseases, including cancer, inflammatory infectious diseases. Recent successes nanoparticle during the coronavirus disease 2019 (COVID-19) pandemic have fueled enthusiasm further. In this review, most developments in nanovaccines disease, allergic nanoadjuvants summarized. Additionally, challenges clinical translation unique class materials discussed.

Language: Английский

Citations

7
The Current Status and Development Forecasts of Vaccines for Aquaculture and its Effects on Bacterial and Viral Diseases DOI

Evodia Moses Mkulo,

Bei Wang, Kwaku Amoah

et al.

Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: unknown, P. 106971 - 106971

Published: Sept. 1, 2024

Language: Английский

Citations

5
Harnessing Nanovaccines for Effective Immunization─A Special Concern on COVID-19: Facts, Fidelity, and Future Prospective DOI
Amol D. Gholap, Juhi Gupta,

Pallavi Kamandar

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2023, Volume and Issue: 10(1), P. 271 - 297

Published: Dec. 14, 2023

Nanotechnology has emerged as a transformative pathway in vaccine research and delivery. Nanovaccines, encompassing lipid nonlipid formulations, exhibit considerable advantages over traditional techniques, including enhanced antigen stability, heightened immunogenicity, targeted distribution, the potential for codelivery with adjuvants or immune modulators. This review provides comprehensive overview of latest advancements applications non-lipid-based nanovaccines current vaccination strategies immunization. The commences by outlining fundamental concepts underlying nanovaccine design before delving into diverse components production processes employed their development. Subsequently, comparative analysis various nanocarriers is presented, elucidating distinct physicochemical characteristics impact on response, along preclinical clinical studies. discussion also highlights how nanotechnology enables possibility personalized combined facilitating creation tailored to meet individual patient needs. ethical aspects concerning use nanovaccines, well safety concerns public perception, are addressed. study underscores gaps challenges that must be overcome adopting practice. offers vital new insights status. It emphasizes significance continuous research, collaboration among interdisciplinary experts, regulatory measures fully unlock enhancing immunization ensuring healthier, more resilient society.

Language: Английский

Citations

13
Nanoparticles as Drug Delivery Carrier-synthesis, Functionalization and Application DOI

Drishya Sajeevan,

Ramakrishna Prasad Are,

Prabhudutta Hota

et al.

Current Pharmaceutical Design, Journal Year: 2024, Volume and Issue: 31(4), P. 244 - 260

Published: April 30, 2024

In recent years, advancements in chemistry have allowed the tailoring of materials at nanoscopic level as needed. There are mainly four main types nanomaterials used drug carriers:metal-based nanomaterials, organic inorganic and polymer nanomaterials. The a carrier showed advantages for decreased side effects with higher therapeutic index. stability compounds increased by encapsulation within nano-drug carriers, leading to systemic toxicity. Nano-drug carriers also controlled release system-made solubility characteristics nanoparticles surface coating surfactants. review focuses on different nanoparticle synthesis process, techniques purposes, applications prospects biomedical applications.

Language: Английский

Citations

4