Comparison of antibody responses of heterologous and homologous Covid-19 booster vaccination: an observational study DOI Creative Commons
Nayab Batool Rizvi, Maryam Bibi, Majeed Rana

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 13, 2024

Objective Pakistan has been seriously affected by the COVID-19 pandemic, with numerous waves of infection. Using different vaccine and booster doses was a key component to control combat this pandemic. This study aims monitor heterologous homologous vaccination that generate immune responses in healthy adults after 9 months vaccination. Methods In cross-sectional, observational total 173 samples were collected. Participants from both genders (Male Female) between ages 18 25 years enrolled for study. who had shots Sinopharm BBIBP CorV Pfizer-BioNTech vaccines included only, use Roche Cobas-e601 analyzer, antibody titers blood serum quantified ECLIA method. IBM SPSS 22 utilized descriptive statistical analysis P< 0.05 considered significant. Results IgG levels measured against full length receptor binding domain (RBD) spike (S) protein. The mean titer Pfizer group 9764 ± 10976 U/mL 5762 4302 group. Mean Pfizer-vaccinated significantly higher than Sinopharm-vaccinated (P=0.000, each). Comparing dosage booster, BNT162b2demonstrated stronger response. However, there no immunological gender-specific significant differences. administration third BNT162b2 two Conclusion BBIBP-CorV is recommended boost humoral response general population while difference observed. More effectiveness can be attained administering additional due decay.

Language: Английский

COVID-19 Vaccine Acceptance and Hesitancy among Healthcare Workers in Lusaka, Zambia; Findings and Implications for the Future DOI Creative Commons
Steward Mudenda, Victor Daka, Scott Kaba Matafwali

et al.

Vaccines, Journal Year: 2023, Volume and Issue: 11(8), P. 1350 - 1350

Published: Aug. 9, 2023

The uptake of COVID-19 vaccines is critical to address the severe consequences disease. Previous studies have suggested that many healthcare workers (HCWs) are hesitant receive vaccine, further enhancing hesitancy rates within countries. vaccine acceptance and levels currently unknown among HCWs in Zambia, which a concern given burden infectious diseases country. Consequently, this study assessed Lusaka, Zambia. A cross-sectional was conducted 240 between August September 2022, using semi-structured questionnaire. Multivariable analysis used determine key factors associated with HCWs. Of who participated, 54.2% were females. total 72.1% would accept being vaccinated, while 27.9% hesitant. Moreover, 93.3% had positive attitudes towards vaccines, medical doctors having highest mean attitude score (82%). Encouragingly, reduced odds (AOR = 0.02, 95% CI: 0.01-0.11,

Language: Английский

Citations

13
XBB1.5-Adapted COVID-19 Vaccine Acceptance Among Dialysis and Kidney Transplant Patients: A Bi-National Survey Study DOI Creative Commons
Georg F. Beilhack, Rossella Monteforte, Florian Frommlet

et al.

Vaccines, Journal Year: 2025, Volume and Issue: 13(3), P. 213 - 213

Published: Feb. 21, 2025

Background: A decrease in governmental vaccination initiatives and diminishing public enthusiasm for vaccines could jeopardize vaccine uptake, potentially endangering those who are most at risk. In this survey study, we evaluated the current acceptance rates of newly developed monovalent XBB1.5-adapted COVID-19 among kidney transplant recipients dialysis patients Austria Israel identified factors influencing acceptance. Methods: The involved a total 656 aged 18 older was carried out from 20 November to 21 December 2023, Medical University Vienna, Rabin Center Petah Tikva, Israel. Logistic regression analysis used explore relationships between variables such as age, gender, country, past infection status severity, renal replacement therapy, education level, willingness receive annual flu vaccine. Results: showed that 54% 63% expressed modified main hesitancy due concerns about potential side effects, with 44% 53% expressing apprehension. influenza vaccine, age Austria, were key predictors greater Conclusions: This study more than 50% our willing adapted Yet, remained significant barrier even these high-risk groups, despite availability an updated targeting Omicron subvariant XBB1.5.

Language: Английский

Citations

0
Motivation and Hesitancies in Obtaining the COVID-19 Vaccine—A Cross-Sectional Study in Norway, USA, UK, and Australia DOI Creative Commons
Janni Leung, Daicia Price, Caitlin McClure‐Thomas

et al.

Vaccines, Journal Year: 2023, Volume and Issue: 11(6), P. 1086 - 1086

Published: June 10, 2023

Background: Vaccinations protect the public against serious diseases or death; however, some individuals are hesitant in obtaining them. We aim to contribute understanding of challenges vaccination roll-out by examining motivations, hesitancies, and their associated factors, COVID-19 vaccines two years into pandemic. Methods: Cross-sectional online surveys were conducted Norway, USA, UK, Australia (N = 1649). The participants self-reported whether they had obtained one vaccines. Those who a vaccine reported reason for motivation, those not hesitancies. Results: More than 80% total sample because health recommendations trusted that it was safe. Among one, most frequent concerns about side effects. Most believed science, but many distrust. vaccine, reports distrust policies science frequent. Concerns effects more common males with lower education, living rural remote areas. Conclusion: People endorsed reduces risk illness, protects others, trust scientific research. Conversely, hesitancy effects, followed healthcare science. These findings could inform strategies increase rates.

Language: Английский

Citations

8
COVID-19 Vaccination Status as Well as Factors Associated with COVID-19 Vaccine Acceptance and Hesitancy among Prisoners and the Implications DOI Creative Commons

Alina Shabir,

Noorah A. Alkubaisi,

Amna Shafiq

et al.

Vaccines, Journal Year: 2023, Volume and Issue: 11(6), P. 1081 - 1081

Published: June 9, 2023

Prisoners form a population who are highly vulnerable to COVID-19 due overcrowding, limited movement, and poor living environment. Consequently, there is need ascertain the status of vaccination factors associated with hesitancy among prisoners. A cross-sectional questionnaire-based study was undertaken prisoners at three district jails in Punjab Province, Pakistan. total 381 participated none participants had received an influenza vaccine this year. In total, 53% least one dose vaccine, majority having two doses. The top reasons acceptance were "fear contracting SARS-CoV-2 infection" (56.9%), "desire return pre-pandemic routine as soon possible" (56.4%), "having no doubts on safety vaccines" (39.6%). There statistically significant difference (p > 0.05) any demographic variables between vaccinated unvaccinated except for age, which strongly association uptake (χ2(3) = 76.645, p < 0.001, Cramer's V 0.457). Among (N 179), only 16 subsequently showed willingness receive vaccine. were: not real problem/disease (60.1%), concerns (51.1%), conspiracy (50.3%). Efforts needed address their given population's risks high rates, especially younger

Language: Английский

Citations

5
Awareness and Practices towards Vaccinating Their Children against COVID-19: A Cross-Sectional Study among Pakistani Parents DOI Open Access

Zain Ul Harmain,

Noorah A. Alkubaisi,

Muhammad Hasnain

et al.

Healthcare, Journal Year: 2023, Volume and Issue: 11(17), P. 2378 - 2378

Published: Aug. 23, 2023

There are typically lower COVID-19 vaccination rates among developing versus higher-income countries, which is exacerbated by greater vaccine hesitancy. However, despite the increasing evidence of safety, parents still reluctant to vaccinate their children against COVID-19. This a concern in countries experiencing successive waves, such as Pakistan. Consequently, objective this study was gain better understanding and practice regarding vaccinating A cross-sectional conducted measure parents’ attitudes towards children. In total, 451 participated study, giving response rate 70.4%; 67.4% were female, 43.2% belonged 40–49 years age group, 47.7% had three children, with 73% fully immunized We found that 84.7% did not consider be very serious issue, 53.9% considered at high risk Overall, only quarter participants currently vaccinated 11.8% willing near future. Parents who knowledge COVID-19, secondary or higher education, chronic illness, those whose been infected more likely have vaccinated. The most common reasons for hesitancy “my child COVID-19” (61%) “I am afraid put/inject foreign object inside my child’s body” (52.2%). acceptance low Those illnesses, its vaccines, significantly (p < 0.001) inclined Effective campaigns well awareness sessions needed address misinformation reduce

Language: Английский

Citations

4
Comparison of antibody responses of heterologous and homologous Covid-19 booster vaccination: an observational study DOI Creative Commons
Nayab Batool Rizvi, Maryam Bibi, Majeed Rana

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 13, 2024

Objective Pakistan has been seriously affected by the COVID-19 pandemic, with numerous waves of infection. Using different vaccine and booster doses was a key component to control combat this pandemic. This study aims monitor heterologous homologous vaccination that generate immune responses in healthy adults after 9 months vaccination. Methods In cross-sectional, observational total 173 samples were collected. Participants from both genders (Male Female) between ages 18 25 years enrolled for study. who had shots Sinopharm BBIBP CorV Pfizer-BioNTech vaccines included only, use Roche Cobas-e601 analyzer, antibody titers blood serum quantified ECLIA method. IBM SPSS 22 utilized descriptive statistical analysis P&lt; 0.05 considered significant. Results IgG levels measured against full length receptor binding domain (RBD) spike (S) protein. The mean titer Pfizer group 9764 ± 10976 U/mL 5762 4302 group. Mean Pfizer-vaccinated significantly higher than Sinopharm-vaccinated (P=0.000, each). Comparing dosage booster, BNT162b2demonstrated stronger response. However, there no immunological gender-specific significant differences. administration third BNT162b2 two Conclusion BBIBP-CorV is recommended boost humoral response general population while difference observed. More effectiveness can be attained administering additional due decay.

Language: Английский

Citations

0