Post COVID-19 vaccination binding and neutralizing antibody with or without previous infection: An 18-month longitudinal study in Indonesia DOI Creative Commons
Tonang Dwi Ardyanto,

Khariri Khariri,

Telly Purnamasari Agus

et al.

Narra J, Journal Year: 2024, Volume and Issue: 4(2), P. e1071 - e1071

Published: Aug. 31, 2024

Due to the persisting development of SARS-CoV-2 variants, studies on kinetics, duration, and function antibodies are essential for vaccine long-term immunity prediction. This longitudinal study examined post-vaccination antibody responses in people after receiving CoronaVac or ChAdOx1 vaccines with without a history infection. Conducted Indonesia between August 2021 May 2023, this involved 121 participants divided into two groups based received types monitored 18 months post-second dose vaccination by assessing binding (BAb) level neutralizing (NAb) inhibition rate at six time points. The also documented participants’ age, gender, body mass index (BMI). Before first vaccination, 85 (70.25%) were reactive BAb (defined ≥50 AU/mL) indicating In group, only 53.1% BAb. However, 100% positive NAb ≥30%), which indicates past infection low initial rapidly decreasing levels. 81,9% reactive, while 54.2% NAb, suggesting recent high but relatively rate. During levels fluctuated. NAb. No significant difference response was among history. Also, no impact presented factors sex, BMI. findings highlight crucial public health how strategies could be optimized effectively during post-pandemic.

Language: Английский

Harnessing Epigenetics: Innovative Approaches in Diagnosing and Combating Viral Acute Respiratory Infections DOI Creative Commons
Ankita Saha, Anirban Ganguly, Anoop Kumar

et al.

Pathogens, Journal Year: 2025, Volume and Issue: 14(2), P. 129 - 129

Published: Feb. 1, 2025

Acute respiratory infections (ARIs) caused by viruses such as SARS-CoV-2, influenza viruses, and syncytial virus (RSV), pose significant global health challenges, particularly for the elderly immunocompromised individuals. Substantial evidence indicates that acute viral can manipulate host's epigenome through mechanisms like DNA methylation histone modifications part of immune response. These epigenetic alterations persist beyond phase, influencing long-term immunity susceptibility to subsequent infections. Post-infection modulation host may help distinguish infected from uninfected individuals predict disease severity. Understanding these interactions is crucial developing effective treatments preventive strategies ARIs. This review highlights critical role following ARIs in regulating innate defense mechanisms. We discuss implications diagnosing, preventing, treating infections, contributing advancement precision medicine. Recent studies have identified specific changes, hypermethylation interferon-stimulated genes severe COVID-19 cases, which could serve biomarkers early detection progression. Additionally, therapies, including inhibitors methyltransferases deacetylases, show promise modulating response improving patient outcomes. Overall, this provides valuable insights into landscape ARIs, extending traditional genetic perspectives. are essential advancing diagnostic techniques innovative address growing threat emerging causing globally.

Language: Английский

Citations

0
The comprehensive insights into the B-cells-mediated immune response against COVID-19 infection amid the ongoing evolution of SARS-CoV-2 DOI
Manish Dhawan, Nanamika Thakur, Manish Sharma

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 185, P. 117936 - 117936

Published: March 8, 2025

Language: Английский

Citations

0
Immunogenicity, Pathogenesis, and Host’s Immuno-Responses to Marburg Virus Infection DOI Creative Commons
Emmanuel Edwar Siddig, Nicaise Ndembi, Ayman Ahmed

et al.

Pathogens, Journal Year: 2025, Volume and Issue: 14(4), P. 323 - 323

Published: March 27, 2025

Due to the sudden emergence and burnout nature of Marburg virus (MARV) outbreaks, little is known about MARV’s pathogenicity immunogenicity. These gaps in knowledge are limiting our understanding disease implementation cost-effective prevention control measures including case management through safe effective therapeutic modalities. Therefore, this review aims synthesize summarize evidence pathogenicity, immunogenicity, virulence humans towards MARV. Upon infection, MARV rapidly disseminates throughout various tissues, provoking severe cellular injury, particularly lymphatic organs, liver, kidneys, gastrointestinal tract. The takes advantage host cells by avoiding immune responses, mainly disrupting function dendritic blocking signaling pathways for interferon. As a result, patients experience profound dysregulation characterized early lymphocyte depletion shift pro-inflammatory cytokine release, resulting storm that can lead hemorrhagic septic shock. Additionally, adaptive antibody production, impaired, further complicating recovery increasing susceptibility outcomes. Understanding these intricate host–pathogen interactions critical developing strategies vaccines against Continuing research essential explain mechanisms evasion identify potential intervention points improving patient

Language: Английский

Citations

0
Beyond the Pandemic Era: Recent Advances and Efficacy of SARS-CoV-2 Vaccines Against Emerging Variants of Concern DOI Creative Commons
Ankita Saha, Sounak Ghosh Roy, Richa Dwivedi

et al.

Vaccines, Journal Year: 2025, Volume and Issue: 13(4), P. 424 - 424

Published: April 17, 2025

Vaccination has been instrumental in curbing the transmission of SARS-CoV-2 and mitigating severity clinical manifestations associated with COVID-19. Numerous COVID-19 vaccines have developed to this effect, including BioNTech-Pfizer Moderna’s mRNA vaccines, as well adenovirus vector-based such Oxford–AstraZeneca. However, emergence new variants subvariants SARS-CoV-2, characterized by enhanced transmissibility immune evasion, poses significant challenges efficacy current vaccination strategies. In review, we aim comprehensively outline landscape emerging concern (VOCs) sub-lineages that recently surfaced post-pandemic years. We assess effectiveness existing their booster doses, against these subvariants, BA.2-derived sub-lineages, XBB BA.2.86 (Pirola). Furthermore, discuss latest advancements vaccine technology, multivalent pan-coronavirus approaches, along development several next-generation coronavirus exosome-based, virus-like particle (VLP), mucosal, nanomaterial-based vaccines. Finally, highlight key critical areas for future research address evolving threat develop strategies combating viral threats, thereby improving preparedness pandemics.

Language: Английский

Citations

0
Post COVID-19 vaccination binding and neutralizing antibody with or without previous infection: An 18-month longitudinal study in Indonesia DOI Creative Commons
Tonang Dwi Ardyanto,

Khariri Khariri,

Telly Purnamasari Agus

et al.

Narra J, Journal Year: 2024, Volume and Issue: 4(2), P. e1071 - e1071

Published: Aug. 31, 2024

Due to the persisting development of SARS-CoV-2 variants, studies on kinetics, duration, and function antibodies are essential for vaccine long-term immunity prediction. This longitudinal study examined post-vaccination antibody responses in people after receiving CoronaVac or ChAdOx1 vaccines with without a history infection. Conducted Indonesia between August 2021 May 2023, this involved 121 participants divided into two groups based received types monitored 18 months post-second dose vaccination by assessing binding (BAb) level neutralizing (NAb) inhibition rate at six time points. The also documented participants’ age, gender, body mass index (BMI). Before first vaccination, 85 (70.25%) were reactive BAb (defined ≥50 AU/mL) indicating In group, only 53.1% BAb. However, 100% positive NAb ≥30%), which indicates past infection low initial rapidly decreasing levels. 81,9% reactive, while 54.2% NAb, suggesting recent high but relatively rate. During levels fluctuated. NAb. No significant difference response was among history. Also, no impact presented factors sex, BMI. findings highlight crucial public health how strategies could be optimized effectively during post-pandemic.

Language: Английский

Citations

3