Attitudes, acceptance and hesitancy among the general population worldwide to receive the COVID-19 vaccines and their contributing factors: A systematic review

EClinicalMedicine, Journal Year: 2021, Volume and Issue: 40, P. 101113 - 101113

Published: Sept. 2, 2021

High rates of vaccination worldwide are required to establish a herd immunity and stop the current COVID-19 pandemic evolution. Vaccine hesitancy is major barrier in achieving across different populations. This study sought conduct systematic review literature regarding attitudes receiving worldwide.A search PubMed Web Science was performed on July 5th, 2021, using developed keywords. Inclusion criteria (1) be conducted English; (2) investigate attitudes, hesitancy, and/or barriers vaccine acceptability among given population; (3) utilize validated measurement techniques; (4) have full text paper available peer-reviewed prior final publication.Following PRISMA guidelines, 209 studies were included. The Newcastle Ottawa (NOS) scale for cross-sectional used assess quality studies.Overall, acceptance ranged considerably between countries time points, with Arabian showing highest compared other parts world.A variety factors contributed increased including having negative perception efficacy, safety, convenience, price. Some consistent socio-demographic groups that identified associated included: women, younger participants, people who less educated, had lower income, no insurance, living rural area, self-identified as racial/ethnic minority.

Language: Английский

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Willingness to Receive the Booster COVID-19 Vaccine Dose in Poland

Vaccines, Journal Year: 2021, Volume and Issue: 9(11), P. 1286 - 1286

Published: Nov. 5, 2021

COVID-19 vaccinations are essential to mitigate the pandemic and prevent severe SARS-CoV-2 infections. However, serum antibody levels in vaccinated individuals gradually decrease over time, while is undergoing an evolution toward more transmissible variants, such as B.1.617.2, ultimately increasing risk of breakthrough infections further virus spread. This cross-sectional online study adult Poles (n = 2427) was conducted September 2021 (before a general recommendation administer booster vaccine dose Poland issued) assess attitude who completed current vaccination regime potential identify factors that may influence it. Overall, 71% participants declared willingness receive dose, with low median level fear receiving it 1.0 (measured by 10-point Likert-type scale), which increased particularly those having worse experience (in terms severity side effects associated fear) past vaccination. The lowest frequency (26.7%) seen group previously Ad26.COV2.S. majority mRNA vaccines wished same vaccine, case AZD1222, accordance observed only 9.1%. main reasons against accepting included experienced after previous doses, opinion unnecessary, safety uncertainties. Women, older (≥50 years), subjects obesity, chronic diseases, pre-vaccination post-vaccination infections, history influenza were significantly frequently willing dose. Moreover, immunosuppressed (88%) additional results emphasize some hesitancy studied indicate groups be targeted effective science communication regarding doses.

Language: Английский

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Multilevel determinants of COVID-19 vaccination hesitancy in the United States: A rapid systematic review

Preventive Medicine Reports, Journal Year: 2021, Volume and Issue: 25, P. 101673 - 101673

Published: Dec. 16, 2021

Vaccine hesitancy is a challenge for the success and optimal implementation of COVID-19 immunization programs in US. The objective this study was to summarize multilevel determinants vaccination intention US inform future intervention opportunities. To end, we conducted rapid systematic review by searching published articles via PubMed October 5, 2021, following PRISMA guidelines. One hundred six were included. According nationally representative studies, overall acceptance rate ranges from 53.6% 84.4%. Individual (demographics, health history, behaviors beliefs), interpersonal (having close friend/family member impacted COVID-19), healthcare societal level factors (healthcare provider recommendations, source/credential related information, conspiracy theories) all contributed vaccine This demonstrates that vaccines influenced various factors, particularly role providers enhancing public intent vaccination. Potential interventions mitigate people's concerns over address vaccine-related conspiracy/misinformation social media are also critical encourage uptake

Language: Английский

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Intention to Receive the COVID-19 Vaccine Booster Dose in a University Community in Italy

Vaccines, Journal Year: 2022, Volume and Issue: 10(2), P. 146 - 146

Published: Jan. 19, 2022

This cross-sectional study, conducted in Naples (Italy) between 16 November and 6 December 2021, explored the willingness to receive booster dose of COVID-19 vaccine among a random sample selected from list those who had completed primary vaccination series at immunization center teaching hospital associated factors. Females significantly higher perceived risk getting SARS-CoV-2 infection, whereas not-having cohabitant were less worried. 85.7% willing dose. Those older respondents better health status after series, have friends/family members diagnosed with COVID-19, received information official government organizations, did not need would be get 24.7% was hesitant Vaccine Hesitancy Scale (VHS) score ≥ 25. Respondents self-rated lower needed hesitant. Information communication regarding benefits efficacy are order control pandemic.

Language: Английский

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Factors influencing COVID-19 vaccine uptake among adults in Nigeria

PLoS ONE, Journal Year: 2022, Volume and Issue: 17(2), P. e0264371 - e0264371

Published: Feb. 24, 2022

Emerging variants of Coronavirus disease 2019 (COVID-19) has claimed over 3000 lives in Nigeria and vaccination remains a means reducing the death toll. Despite ongoing efforts by government to ensure COVID-19 most residents attain herd immunity, myths beliefs have adversely shaped perception Nigerians, challenging uptake vaccine. This study aimed assess factors influencing awareness, perception, willingness receive vaccine among Nigerian adults.A cross-sectional online nationwide was conducted from April June 2021 adult population using snowballing method. Descriptive analysis used summarise data. Univariate multivariate identify predictors respondents. A p value <0.05 considered significant.A total 1058 completed forms were analysed 63.9% females. The mean age 40.8 years±12.2 years. Most respondents (740; 69.5%) had satisfactory awareness exercise. media main source information. Health workers reported higher level (aOR = 1.822, 95% CI: 1.388-2.524, p<0.001). Respondents that are Christians Muslims better compared unaffiliated 6.398, 1.918-21.338, P 0.003) 7.595, 2.280-25.301, p<0.001) respectively. There is average score for statements (566; 53.2%) towards vaccination. Close half (44.2%) found short period production worrisome. Majority willing get (856; 80.9%). Those without prior diagnosis lower vaccinated 0.210 (95% 0.082-0.536) 0.001).The revealed high moderate activities. Influencing significantly affects religion, occupation, education COVID-19; willingness-occupation, factors.

Language: Английский

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mRNA vaccines: The future of prevention of viral infections?

Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(2)

Published: Feb. 1, 2023

Abstract Messenger RNA (mRNA) vaccines against COVID‐19 are the first authorized biological preparations developed using this platform. During pandemic, their administration has been proven to be a life‐saving intervention. Here, we review main advantages of mRNA vaccines, identify further technological challenges met during development platform, and provide an update on clinical progress leading vaccine candidates different viruses that include influenza viruses, human immunodeficiency virus 1, respiratory syncytial virus, Nipah Zika cytomegalovirus, Epstein‐Barr virus. The prospects manufacturing in low‐income countries also discussed. ongoing interest research technology likely overcome some existing for (e.g., related storage conditions immunogenicity components lipid nanoparticles) enhance portfolio diseases which classical formulations already authorized. It may open novel pathways protection infections consequences no safe efficient immunization methods currently available.

Language: Английский

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COVID-19 Vaccine Acceptance of Pregnant and Lactating Women (PLW) in Czechia: An Analytical Cross-Sectional Study

International Journal of Environmental Research and Public Health, Journal Year: 2021, Volume and Issue: 18(24), P. 13373 - 13373

Published: Dec. 19, 2021

Pregnant and lactating women (PLW) represent a particular population subset with increased susceptibility for COVID-19 morbidity mortality, even though the evidence about safety efficacy of vaccines was delayed due to their initial exclusion from development trials. This unclear situation could have led vaccine hesitancy levels among PLW; therefore, this study aimed evaluate attitudes Czech PLW towards determinants attitudes. An analytical cross-sectional survey-based carried out in University Hospital Brno (South Moravia, Czechia) between August October 2021. The utilised self-administered questionnaire (SAQ) adapted previous instruments used same purpose. SAQ included closed-ended items covering demographic characteristics, clinical obstetric vaccination, potential psychosocial predictors acceptance. Out 362 participants, 278 were pregnant (PW) 84 (LW). overall acceptance (immediate delayed) level substantially high (70.2%), significant difference PW (76.6%) LW (48.8%). 70.2% who agreed receive vaccine, 3.6% indicated immediate acceptance, 66.6% Only 13.3% participants physician's vaccination recommendation during pregnancy or while lactating, 62.2% against it. Our results recent studies that revealed tended they also inclined resist professional recommendations because predominantly preferred delay vaccination. trimester, education level, employment status, live births most commonly type mRNA-based vaccines, followed by viral vector-based inactivated virus vaccines. first top priority children, effectiveness. Regarding predictors, media/social media, trust government, pharmaceutical industry, healthcare professionals, partners, positive risk-benefit ratio promoters Findings suggest promotional interventions targeting should use web platforms focus on evidence, expected benefits harms infection.

Language: Английский

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Knowledge about, attitude and acceptance towards, and predictors of intention to receive the COVID-19 vaccine among cancer patients in Eastern China: A cross-sectional survey

Journal of Integrative Medicine, Journal Year: 2021, Volume and Issue: 20(1), P. 34 - 44

Published: Oct. 27, 2021

Language: Английский

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Thrombotic Thrombocytopenia after COVID-19 Vaccination: In Search of the Underlying Mechanism

Vaccines, Journal Year: 2021, Volume and Issue: 9(6), P. 559 - 559

Published: May 27, 2021

The rollout of COVID-19 vaccines brings hope for successful pandemic mitigation and getting the transmission SARS-CoV-2 under control. authorized in Europe displayed a good safety profile clinical trials. However, during their post-authorization use, unusual thrombotic events associated with thrombocytopenia have rarely been reported vector vaccines. This led to temporary suspension AZD1222 vaccine (Oxford/AstraZeneca) various European countries Ad26.COV2 (Janssen/Johnson&Johnson) United States, regulatory bodies launching investigations into potential causal associations. thromboembolic reactions were also after mRNA exact cause these adverse effects remains be elucidated. present paper outlines hypotheses on mechanisms behind very rare vaccination, along currently existing evidence future research prospects. following are discussed: (i) role antibodies against platelet factor 4 (PF4), (ii) direct interaction between adenoviral platelets, (iii) cross-reactivity spike protein PF4, (iv) anti-adenovirus (v) (vi) expression subsequent immune response, (vii) other proteins reactions. It is plausible that multifactorial. elucidation causes pivotal taking precautionary measures managing hesitancy. needs stressed, however, cases sporadic benefits vastly outweigh risks.

Language: Английский

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Is It All a Conspiracy? Conspiracy Theories and People’s Attitude to COVID-19 Vaccination

Vaccines, Journal Year: 2021, Volume and Issue: 9(10), P. 1051 - 1051

Published: Sept. 22, 2021

A large body of research has found that people’s beliefs in conspiracy theories about infectious diseases negatively impacts their health behaviors concerning vaccination. Conspiracy belief-based vaccination hesitancy become more rampant after the global outbreak COVID-19. However, some important questions remain unanswered. For instance, do different versions theories—particularly origin epidemic (e.g., SARS-CoV-2 leaked from a Wuhan virology laboratory or virus was foreign origin) and general vaccine conspiracies pharmaceutical companies covered up danger vaccines people are being deceived effectiveness vaccines)—have same effect on intentions? Through national survey adopting quota sampling China, current study tested relationship between intention to receive COVID-19 The findings show embrace did indeed affect take shots. only related had significant impact, while belief not significantly intentions. People’s knowledge (vaccine literacy) played an role this relationship. People with lower higher levels literacy were likely

Language: Английский

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