Antiviral effects of Atractyloside A on the influenza B virus (Victoria strain) infection DOI Creative Commons

Jicheng Han,

Xiangyu Zhu, Zihan Gao

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: Jan. 10, 2023

Influenza viruses pose a serious threat to human health, infecting hundreds of millions people worldwide each year, resulting in significant increase global morbidity and mortality. activity has declined at the onset COVID-19 pandemic, but genetic diversity B/Victoria lineage increased significantly during this period. Therefore, prevention treatment influenza B Victoria strain virus should continue attract research attention. In study, we found that Atractyloside A (AA), one effective components Atractylodes lancea (Thunb.) DC shows potential antiviral properties. This study AA not only possesses anti-influenza infection effects vivo vitro also can regulate macrophage polarization M2 type, which effectively attenuate damage caused by infection. may be an natural drug against

Language: Английский

Molnupiravir: A lethal mutagenic drug against rapidly mutating severe acute respiratory syndrome coronavirus 2—A narrative review DOI
Sri Masyeni, Muhammad Iqhrammullah, Andri Frediansyah

et al.

Journal of Medical Virology, Journal Year: 2022, Volume and Issue: 94(7), P. 3006 - 3016

Published: March 22, 2022

Broad-spectrum antiviral agents targeting viral RNA-dependent RNA polymerase (RdRp) are expected to be a key therapeutic strategy in the ongoing coronavirus disease 2019 (COVID-19) pandemic and its future variants of severe acute respiratory syndrome 2 (SARS-CoV-2), virus that causes COVID-19. Molnupiravir is nucleoside analog vivo experiments have been reported inhibit replication SARS-CoV-2, Clinical trials molnupiravir as therapy for patients with mild-to-moderate COVID-19 also suggest significant efficacy comparison placebo. lethally mutagenic against RNA, but effect on host cell DNA being questioned. Herein, safety concerns discussed recent findings from published reports clinical trials. The unchanged mutated SARS-CoV-2 highlighted. With administration via oral route, turn tide pandemic.

Language: Английский

Citations

62
In vitro and computational insights revealing the potential inhibitory effect of Tanshinone IIA against influenza A virus DOI
Dalia Elebeedy,

Ingy Badawy,

Ayman Abo Elmaaty

et al.

Computers in Biology and Medicine, Journal Year: 2021, Volume and Issue: 141, P. 105149 - 105149

Published: Dec. 17, 2021

Language: Английский

Citations

56
Newly synthesized series of oxoindole–oxadiazole conjugates as potential anti-SARS-CoV-2 agents:in silicoandin vitrostudies DOI

Rana M. El-Masry,

Ahmed A. Al‐Karmalawy, Radwan Alnajjar

et al.

New Journal of Chemistry, Journal Year: 2022, Volume and Issue: 46(11), P. 5078 - 5090

Published: Jan. 1, 2022

The pharmacophoric features of the novel series 1,3,4-oxadiazole–oxoindole conjugates (IVa–g) as potential anti-SARS-CoV-2 agents based on reported M pro inhibitor (Ia) are presented.

Language: Английский

Citations

55
Anticoagulants as Potential SARS-CoV-2 Mpro Inhibitors for COVID-19 Patients: In Vitro, Molecular Docking, Molecular Dynamics, DFT, and SAR Studies DOI Open Access
Ayman Abo Elmaaty, Wagdy M. Eldehna, Muhammad Khattab

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(20), P. 12235 - 12235

Published: Oct. 13, 2022

In this article, 34 anticoagulant drugs were screened in silico against the main protease (Mpro) of SARS-CoV-2 using molecular docking tools. Idraparinux, fondaparinux, eptifibatide, heparin, and ticagrelor demonstrated highest binding affinities towards Mpro. A dynamics study at 200 ns was also carried out for most promising anticoagulants to provide insights into dynamic thermodynamic properties compounds. Moreover, a quantum mechanical conducted which helped us attest some findings. biological evaluation (in vitro) compounds performed by carrying MTT cytotoxicity assay crystal violet order assess inhibitory concentration 50 (IC50). It is worth noting that displayed intrinsic potential inhibition with an IC50 value 5.60 µM safety index 25.33. addition, fondaparinux sodium dabigatran showed activities values 8.60 9.40 µM, respectively, indexes 17.60 15.10, respectively. Mpro enzyme investigated utilizing tipranavir as reference standard. Interestingly, attained 2.36 surpassing (IC50 = 7.38 µM) more than three-fold. Furthermore, highly eligible 10.59 µM. Finally, SAR discussed, counting on findings both vitro approaches.

Language: Английский

Citations

42
A Systematic Review of the Global Intervention for SARS-CoV-2 Combating: From Drugs Repurposing to Molnupiravir Approval DOI Creative Commons

Nada A. Ashour,

Ayman Abo Elmaaty,

Amany A. Sarhan

et al.

Drug Design Development and Therapy, Journal Year: 2022, Volume and Issue: Volume 16, P. 685 - 715

Published: March 1, 2022

Abstract: The rising outbreak of SARS-CoV-2 continues to unfold all over the world. development novel effective antiviral drugs fight against is a time cost. As result, some specific FDA-approved have already been repurposed and authorized for COVID-19 treatment. used were either or non-antiviral drugs. Accordingly, present review thoroughly focuses on repurposing efficacy these including clinical trials experienced, combination therapies used, methods followed treatment, their future perspective. Therefore, drug was regarded as an avenue Recently, molnupiravir prodrug medication that approved in United Kingdom November 2021 treatment COVID-19. On other hand, PF-07321332 oral developed by Pfizer. For COVID-19, PF-07321332/ritonavir Phase III studies marketed Paxlovid. Herein, we represented almost history combating from recently available anti-SARS-CoV-2 candidates, new hope end current pandemic. Graphical Keywords: SARS-CoV-2, repurposing, trials, molnupiravir, paxlovid

Language: Английский

Citations

40
Bioactive Azadirachta indica and Melia azedarach leaves extracts with anti-SARS-CoV-2 and antibacterial activities DOI Creative Commons

Bahaa A. Hemdan,

Ahmed Mostafa,

Marwa M. Elbatanony

et al.

PLoS ONE, Journal Year: 2023, Volume and Issue: 18(3), P. e0282729 - e0282729

Published: March 8, 2023

The leaves of Azadirachta indica L. and Melia azedarach L., belonging to Meliaceae family, have been shown medicinal benefits are extensively employed in traditional folk medicine. Herein, HPLC analysis the ethyl acetate fraction total methanolic extract emphasized enrichment both A . M extracts with phenolic flavonoids composites, respectively. Besides, 4 limonoids 2 were isolated using column chromatography. By assessing vitro antiviral activities against Severe Acute Respiratory Syndrome Corona virus (SARS-CoV-2), it was found that robust anti-SARS-CoV-2 at low half-maximal inhibitory concentrations (IC 50 ) 8.451 6.922 μg/mL, Due high safety cytotoxic (CC 446.2 351.4 μg/ml, respectively, displayed extraordinary selectivity indices (SI>50). could induce antibacterial Gram-negative positive bacterial strains. minimal varied from 25 100 mg/mL within 30 min contact time towards tested bacteria. Our findings confirm broad-spectrum value extracts. Finally, additional vivo investigations highly recommended anti-COVID-19 antimicrobial plant

Language: Английский

Citations

24
Zoonosis and zooanthroponosis of emerging respiratory viruses DOI Creative Commons
Ahmed Magdy Khalil, Luis Martínez‐Sobrido,

Ahmed Mostafa

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 13

Published: Jan. 5, 2024

Lung infections in Influenza-Like Illness (ILI) are triggered by a variety of respiratory viruses. All human pandemics have been caused the members two major virus families, namely Orthomyxoviridae (influenza A viruses (IAVs); subtypes H1N1, H2N2, and H3N2) Coronaviridae (severe acute syndrome coronavirus 2, SARS−CoV−2). These acquired some adaptive changes known intermediate host including domestic birds (IAVs) or unknown (SARS-CoV-2) following transmission from their natural reservoirs (e.g. migratory bats, respectively). Verily, these substitutions facilitated crossing species barriers to infect humans phenomenon that is as zoonosis. Besides, aided variant strain transmit horizontally other contact non-human animal pets wild animals (zooanthroponosis). Herein we discuss main zoonotic reverse-zoonosis events occurred during last influenza A/H1N1 SARS-CoV-2. We also highlight impact interspecies pandemic on evolution possible prophylactic therapeutic interventions. Based information available presented this review article, it important close monitoring viral zoonosis reverse strains within One-Health One-World approach mitigate unforeseen risks, such resistance limited

Language: Английский

Citations

9
Ligand-based design, synthesis, computational insights, andin vitrostudies of novelN-(5-Nitrothiazol-2-yl)-carboxamido derivatives as potent inhibitors of SARS-CoV-2 main protease DOI Creative Commons
Mohamed Elagawany, Ayman Abo Elmaaty,

Ahmed Mostafa

et al.

Journal of Enzyme Inhibition and Medicinal Chemistry, Journal Year: 2022, Volume and Issue: 37(1), P. 2112 - 2132

Published: July 31, 2022

The global outbreak of the COVID-19 pandemic provokes scientists to make a prompt development new effective therapeutic interventions for battle against SARS-CoV-2. A series

Language: Английский

Citations

35
Investigating the possible mechanisms of pirfenidone to be targeted as a promising anti-inflammatory, anti-fibrotic, anti-oxidant, anti-apoptotic, anti-tumor, and/or anti-SARS-CoV-2 DOI
Samar A. Antar, Mohamed A. Saleh, Ahmed A. Al‐Karmalawy

et al.

Life Sciences, Journal Year: 2022, Volume and Issue: 309, P. 121048 - 121048

Published: Oct. 7, 2022

Language: Английский

Citations

34
Identification of Natural Lead Compounds against Hemagglutinin-Esterase Surface Glycoprotein in Human Coronaviruses Investigated via MD Simulation, Principal Component Analysis, Cross-Correlation, H-Bond Plot and MMGBSA DOI Creative Commons
Iqra Ali, Muhammad Asif Rasheed, Simona Cavalu

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(3), P. 793 - 793

Published: March 6, 2023

The pandemic outbreak of human coronavirus is a global health concern that affects people all ages and genders, but there currently still no effective, approved potential drug against coronavirus, as many other vaccines have serious side effects while the development small antiviral inhibitors has gained tremendous attention. For this research, HE was used therapeutic target, spike protein displays high binding affinity for both host ACE2 viral glycoprotein. Molecular docking, pharmacophore modelling virtual screening 38,000 natural compounds were employed to find out best inhibitor coronaviruses with more efficiency fewer further evaluated via MD simulation, PCA, DCCR MMGBSA. lead compound 'Calceolarioside B' identified on basis pharmacophoric features which depict favorable (ΔGbind -37.6799 kcal/mol) HE(5N11) receptor describes positive correlation movements in active site residues better stability, robust H-bond network, compactness reliable ADMET properties. Fraxinus sieboldiana Blume plant containing Calceolarioside B could be shows higher efficacy potency effects. This research work will aid investigators testing identification chemicals are effective useful coronavirus.

Language: Английский

Citations

21