Vaccines,
Journal Year:
2023,
Volume and Issue:
11(8), P. 1347 - 1347
Published: Aug. 9, 2023
After
two
years
since
the
declaration
of
COVID-19
as
a
pandemic
by
World
Health
Organization
(WHO),
more
than
six
million
deaths
have
occurred
due
to
SARS-CoV-2,
leading
an
unprecedented
disruption
global
economy.
Fortunately,
within
year,
wide
range
vaccines,
including
pathogen-based
inactivated
and
live-attenuated
replicating
non-replicating
vector-based
nucleic
acid
(DNA
mRNA)-based
protein-based
subunit
virus-like
particle
(VLP)-based
been
developed
mitigate
severe
impacts
pandemic.
These
vaccines
proven
highly
effective
in
reducing
severity
illness
preventing
deaths.
However,
availability
supply
become
issue
prioritization
vaccine
distribution
most
countries.
Additionally,
virus
continues
mutate
spread,
questions
arisen
regarding
effectiveness
against
new
strains
SARS-CoV-2
that
can
evade
host
immunity.
The
urgent
need
for
booster
doses
enhance
immunity
has
recognized.
scarcity
“safe
effective”
exacerbated
inequalities
terms
coverage.
development
fallen
short
expectations
set
forth
2020
2021.
Furthermore,
equitable
at
national
levels
remains
challenge,
particularly
developing
In
such
circumstances,
exigency
plant
virus-based
apparent
means
overcome
shortages
through
fast
manufacturing
processes
enable
quick
convenient
millions
people
without
reliance
on
cold
chain
system.
Moreover,
demonstrated
both
safety
efficacy
eliciting
robust
cellular
immunogenicity
pathogens.
This
review
aims
shed
light
advantages
disadvantages
different
types
provide
update
current
status
plant-based
fight
The Lancet Global Health,
Journal Year:
2024,
Volume and Issue:
12(6), P. e1059 - e1067
Published: April 15, 2024
The
essence
of
a
vaccine
lies
in
its
ability
to
elicit
set
immune
responses
specifically
directed
at
particular
pathogen.
Accordingly,
vaccines
were
historically
designed,
developed,
registered,
recommended,
procured,
and
administered
as
monopathogen
formulations.
Nonetheless,
the
control
elimination
an
astonishing
number
diseases
was
realised
only
after
several
once-separate
provided
combinations.
Unfortunately,
current
superabundance
recommended
pipeline
is
now
odds
with
acceptable
administrations
feasible
health-care
visits
for
recipients
providers.
Yet,
few
new
combinations
are
development
because,
addition
scientific
manufacturing
hurdles
intrinsic
coformulation,
developers
face
gauntlet
regulatory,
policy,
commercialisation
obstacles
milieu
still
largely
designed
vaccines.
We
argue
here
that
national
policy
makers
public
health
agencies
should
prospectively
identify
advocate
multipathogen
combination
vaccines,
suggest
ways
accelerate
regulatory
pathways
licensure
other
concrete,
innovative
steps
mitigate
obstacles.
International Medical Science Research Journal,
Journal Year:
2024,
Volume and Issue:
4(1), P. 89 - 107
Published: Jan. 23, 2024
This
comprehensive
review
examines
the
epidemiology
of
COVID-19
pandemic,
shedding
light
on
pivotal
lessons
learned
and
their
implications
for
future
healthcare
preparedness.
Analyzing
global
landscape
virus,
delves
into
transmission
dynamics,
risk
factors
influencing
severe
outcomes,
effectiveness
diverse
public
health
interventions.
It
provides
a
nuanced
exploration
challenges
encountered
by
systems
worldwide,
elucidating
strengths
vulnerabilities
brought
to
forefront
pandemic.
The
study
underscores
need
multifaceted
approach
preparedness,
emphasizing
critical
importance
integrated
surveillance
systems,
agile
response
mechanisms,
implementation
evidence-based
strategies.
Drawing
experiences
from
regions,
identifies
key
in
pandemic
management,
showcasing
successful
strategies
innovative
interventions
that
have
proven
effective
curbing
virus's
spread.
Moreover,
role
vaccination
campaigns
shaping
trajectory
emphasizes
vital
contribution
technology
bolstering
resilience.
As
world
grapples
with
long-term
effects
COVID-19,
this
aims
distill
essential
insights
can
inform
preparedness
efforts.
By
synthesizing
knowledge
gleaned
posed
analysis
offers
foundation
strategies,
guiding
towards
enhanced
readiness
confront
mitigate
impact
infectious
threats.
Keywords:
Pandemic,
Epidemiology,
Healthcare,
Review.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(23)
Published: June 8, 2023
Abstract
Vaccines
provide
a
powerful
tool
to
modulate
the
immune
system
for
human
disease
prevention
and
treatment.
Classical
vaccines
mainly
initiate
responses
in
lymph
nodes
(LNs)
after
subcutaneous
injection.
However,
some
suffer
from
inefficient
delivery
of
antigens
LNs,
undesired
inflammation,
slow
induction
when
encountering
rapid
proliferation
tumors.
Alternatively,
spleen,
as
largest
secondary
lymphoid
organ
with
high
density
antigen‐presenting
cells
(APCs)
lymphocytes,
acts
an
emerging
target
vaccinations
body.
Upon
intravenous
administration,
rationally
designed
spleen‐targeting
nanovaccines
can
be
internalized
by
APCs
spleen
induce
selective
antigen
presentation
T
B
their
specific
sub‐regions,
thereby
rapidly
boosting
durable
cellular
humoral
immunity.
Herein,
recent
advances
immunotherapy
based
on
anatomical
architectures
functional
zones
well
limitations
perspectives
clinical
applications
are
systematically
summarized.
The
aim
is
emphasize
design
innovative
enhanced
intractable
diseases
future.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 2, 2024
Vaccines
are
considered
the
most
effective
tools
for
preventing
diseases.
In
this
sense,
with
Covid-19
pandemic,
effects
of
which
continue
all
over
world,
humanity
has
once
again
remembered
importance
vaccine.
Also,
various
epidemic
outbreaks
that
occurred
previously,
development
processes
vaccines
against
these
viral
pathogens
have
accelerated.
By
efforts,
many
different
new
vaccine
platforms
been
approved
commercial
use
and
introduced
to
landscape.
addition,
innovations
made
in
production
carried
out
conventionally
produced
types
create
a
rapid
response
prevent
potential
epidemics
or
pandemics.
situation,
cell
lines
being
positioned
at
center
generation
as
expression
platforms.
Therefore,
since
main
goal
is
produce
fast,
safe,
disease,
addition
existing
systems,
not
used
until
now
included
first
time.
review,
current
clinical
today
described.
Then,
reason
using
lines,
vaccines,
general
culture-based
mentioned.
selection
parameters
animal
explained
by
considering
bioprocess
efficiency
regulations.
Finally,
their
properties
summarized,
an
emphasis
on
future
status
cultures
industrial
production.
Food Reviews International,
Journal Year:
2022,
Volume and Issue:
39(8), P. 4909 - 4940
Published: March 3, 2022
Edible
fungus
polysaccharide
(EFP)
is
mainly
extracted
from
the
fruiting
body,
mycelium
and
fermentation
broth
of
fungi.
As
one
main
bioactive
components,
EFP
has
potential
health
promoting
effects.
Its
biological
activities
such
as
enhancing
immunity,
anti-tumor,
anti-radiation,
delaying
aging
antioxidation.
It
been
widely
used
in
food,
products,
medicine
other
industries.
The
activity
related
to
its
radical
group.
isolation,
purification
structure
identification
are
premise
bioactivity
research
application
EFP.
At
present,
on
polysaccharides
their
structures
helpful
guide
develop
pharmacological
effects,
products.
This
paper
reviews
status
extraction,
determination
EFP,
NMR,
methylation
analysis
some
methods
carbohydrate
chemical
characterization.
In
addition,
progress
functional
fields
were
described,
so
provide
basis
reference
for
further
study
Cells,
Journal Year:
2023,
Volume and Issue:
12(2), P. 317 - 317
Published: Jan. 14, 2023
Tuberculosis
(TB)
is
still
the
leading
global
cause
of
death
from
an
infectious
bacterial
agent.
Limiting
tuberculosis
epidemic
spread
therefore
urgent
public
health
priority.
As
stated
by
WHO,
to
stop
disease
we
need
a
new
vaccine,
with
better
coverage
than
current
