Science Letters,
Journal Year:
2024,
Volume and Issue:
12(1), P. 27 - 42
Published: March 25, 2024
Honey
bees
are
important
pollinators
that
support
food
security
and
nature’s
biodiversity.
They
also
a
source
of
various
honey
bee-derived
products
(api-products)
used
in
the
food,
pharmaceutical,
cosmetic
industries.
However,
biological,
chemical
physical
factors
threaten
population
biodiversity
feral
managed
bees.
These
challenges
have
not
been
elaborated
upon
Pakistani
context;
therefore,
this
review
aims
to
identify
describe
menaces
domesticated
populations
Pakistan.
Four
bee
species
reported
country,
with
Western
(Apis
mellifera)
currently
being
main
species.
Climate
change
urbanization
altering
habitats
Additionally,
agrochemicals
extensively
manage
emerging
pests,
exacerbating
environmental
pollution.
The
air
quality
majority
urban
areas
is
toxic
for
Although
remote
forest
can
provide
habitat
these
insects,
low
cover
non-sustainable
silviculture
still
significant
hurdles.
Microplastics
antimicrobials
impacting
fitness
appear
their
products,
making
it
One-Health
issue.
Electromagnetic
signals
influence
health
behavior.
Overall,
all
colony
fitness,
ultimately
causing
declines
both
wild
purpose
information
assist
decision-makers,
researchers,
beekeepers
educators
comprehending
obstacles
faced
by
within
context
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: July 18, 2024
Honeybees
have
been
helpful
insects
since
ancient
centuries,
and
this
benefit
is
not
limited
to
being
a
honey
producer
only.
After
the
bee
stings
person,
pain,
swelling
occur
in
place,
due
effects
of
venom
(BV).
This
poison
total
sense
word
because
it
has
many
benefits,
its
composition
rich
proteins,
peptides,
enzymes,
other
types
molecules
low
concentrations
that
show
promise
treatment
numerous
diseases
conditions.
BV
also
demonstrated
positive
against
various
cancers,
antimicrobial
activity,
wound
healing
versus
human
immunodeficiency
virus
(HIV).
Even
though
topical
therapy
used
varying
degrees
among
countries,
localized
or
itching
are
common
side
may
some
patients.
review
provides
an
in-depth
analysis
complex
chemical
BV,
highlighting
diverse
range
bioactive
compounds
their
therapeutic
applications,
which
extend
beyond
well-known
anti-inflammatory
pain-relieving
effects,
showcasing
versatility
modern
medicine.
A
specific
search
strategy
was
followed
across
databases;
Web
sciences,
Scopus,
Medline,
Google
Scholar
including
vitro
vivo
clinical
studies.to
outline
overview
composition,
methods
use,
preparation
requirements,
Individual
consumption
contraindications.
Furthermore,
addresses
safety
concerns
emerging
approaches,
such
as
use
nanoparticles,
mitigate
adverse
demonstrating
balanced
holistic
perspective.
Importantly,
incorporates
historical
context
traditional
uses,
well
unique
focus
on
veterinary
setting
apart
from
previous
works
providing
valuable
resource
for
researchers
practitioners
field.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(5), P. 646 - 646
Published: May 16, 2024
Beekeeping
provides
products
with
nutraceutical
and
pharmaceutical
characteristics.
These
are
characterized
by
abundance
of
bioactive
compounds.
For
different
reasons,
honey,
royal
jelly,
propolis,
venom,
pollen
beneficial
to
humans
animals
could
be
used
as
therapeutics.
The
pharmacological
action
these
is
related
many
their
constituents.
main
components
honey
include
oligosaccharides,
methylglyoxal,
jelly
proteins
(MRJPs),
phenolics
Royal
contains
jelleins,
royalisin
peptides,
MRJPs,
derivatives
hydroxy-decenoic
acid,
particularly
10-hydroxy-2-decenoic
acid
(10-HDA),
which
possess
antibacterial,
anti-inflammatory,
immunomodulatory,
neuromodulatory,
metabolic
syndrome-preventing,
anti-aging
properties.
Propolis
has
a
plethora
activities
that
referable
compounds
such
caffeic
phenethyl
ester.
Peptides
found
in
bee
venom
phospholipase
A2,
apamin,
melittin.
In
addition
being
vitamin-rich,
also
includes
unsaturated
fatty
acids,
sterols,
express
antiatherosclerotic,
antidiabetic,
anti-inflammatory
Therefore,
the
constituents
hive
particular
different.
All
have
been
investigated
for
properties
numerous
research
studies.
This
review
aims
provide
thorough
screening
chemicals
honeybee
biological
effects.
manuscript
may
impetus
branch
unconventional
medicine
goes
name
apitherapy.
Insects,
Journal Year:
2025,
Volume and Issue:
16(2), P. 168 - 168
Published: Feb. 5, 2025
The
mite
Varroa
destructor
is
widely
acknowledged
as
the
most
destructive
threat
to
honey
bee
(Apis
mellifera)
colonies
on
a
global
scale.
infestations
in
are
intricately
linked
with
viral
infections,
collaboratively
leading
diminished
populations
and
accelerated
colony
losses.
Extensive
research
has
firmly
established
correlation
between
varroa
mites
viruses,
underscoring
mite’s
efficiency
spreading
viruses
among
bees
colonies.
effective
control
of
expected
result
decrease
infections
within
Research
suggests
that
thermal
treatments
(hyperthermia)
present
viable
approach
combat
mites,
studies
demonstrating
role
heat
stress
reducing
affected
bees.
This
article
examines
extant
literature
surrounding
utilization
hyperthermia
potential
method
ameliorate
adverse
impacts
their
associated
It
also
outlines
characteristics
these
stressors.
Diverse
devices
can
be
used
for
subjecting
treatment,
targeting
both
outside
brood
cells.
application
treatments,
typically
ranging
40
42
°C
1.5–3
h,
reduce
shown
promise.
Notably,
precise
effectiveness
treatment
comparison
alternative
measures
remains
uncertain
available
literature.
deleterious
repercussions
this
mechanism
immature
mature
evaluated.
Concurrently,
detrimental
implications
prolonged
durations
discussed.
Regarding
impact
them
negatively
by
either
or
inducing
production
shock
proteins
possess
antiviral
properties.
Various
factors
identified
influential
efficacy
colonies,
including
device
type
duration,
necessitating
further
empirical
investigations.
Additionally,
highlights
existing
gaps
knowledge
provides
insights
into
prospective
directions
concerning
method.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 13, 2024
Background:
Rheumatoid
arthritis
(RA)
is
an
erosive-destructive
inflammation
of
the
joints,
and
chronic,
long-term
stiffness
deformation
induced
by
RA
are
some
symptoms
that
difficult
to
treat.
Dexamethasone
(DEX)
melittin
(MLT)
two
interesting
anti-inflammatory
substances,
both
which
possess
effects
exerted
through
suppression
immune
system.
The
purpose
this
study
was
explore
role
MLT
in
treatment
DEX
as
well
clarify
influence
on
efficacy
side
DEX.
Method:
rats
were
injected
with
Complete
Freund’s
Adjuvant
(CFA)
induce
arthritis,
followed
different
doses
and/or
MLT.
relevant
indexes
paw
determined,
appetite,
growth
status,
cytokine
levels,
organ
coefficient
evaluated.
In
addition,
paraffin
sections
joint
tissues
prepared
analyze
pathological
changes.
Result:
exhibited
effects,
notably
hindering
feed
intake
growth,
inducing
lesions
rats.
significantly
reduced
promoted
its
efficacy.
combination
demonstrated
a
synergistic
treatment,
showing
advantages
detumescence
reduction,
pro-inflammatory
inhibition,
internal
improvement.
Conclusion:
Thus,
adjuvant
rats,
offering
approach
reduce
use
dosage
Aquaculture and Fisheries,
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 1, 2024
Bee
venom
(BV)
has
been
widely
studied
for
its
therapeutic
properties
in
various
medical
applications.
However,
effects
on
aquatic
organisms,
particularly
Nile
tilapia
(Oreochromis
niloticus),
remain
poorly
understood,
concerning
toxicity
and
impacts.
This
study
investigated
the
of
bee
injection
(O.
niloticus)
by
examining
growth,
feed
efficiency,
biometric
parameters,
whole-body
chemical
analysis,
activity
antioxidant
enzymes
liver.
juveniles
were
injected
with
BV
at
doses
0,
3,
6,
9,
12
mg/kg
fish
weight.
Observations
made
14th
day
post-injection
(DPI).
No
significant
differences
found
utilization,
survival
rate,
indices,
composition
among
dosage
groups.
Similarly,
intestinal
(amylase,
protease,
lipase)
showed
no
changes.
revealed
a
time-dependent
response
(SOD,
CAT,
GPx)
liver,
peaks
4th
6th
DPI.
On
DPI,
9
exhibited
higher
enzyme
activities
compared
to
control
highest
group
(12
mg/kg).
These
results
imply
presence
potential
adaptive
favorable
influence
health
immune
responses
following
injection.
Notably,
appear
vary
dose,
influencing
both
immunity.
Further
research
is
warranted
explore
long-term
exposure
applications
aquaculture.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(5), P. 560 - 560
Published: April 27, 2024
Growing
concern
over
antimicrobial
resistance
in
chronic
wound
patients
necessitates
the
exploration
of
alternative
treatments
from
natural
sources.
This
study
suggests
that
honey’s
phenolic
compounds
may
offer
benefits,
warranting
further
investigation
for
therapeutic
development.
The
main
aim
this
was
to
investigate
activity
and
determine
effects
their
sub-inhibitory
concentrations
against
Escherichia
coli
(E.
coli).
3-phenyllactic
acid
(PLA),
p-coumaric
(PCA),
phloretin
were
tested
bacterial
strain
E.
ATCC
25922.
Comparison
honey
constituents
vitro
performed
using
a
broth
culture
assay.
Measurement
inhibitory
properties
conducted
disc
well
diffusion
assays.
PCA
on
susceptibility
25922
penicillin–streptomycin
tested.
results
demonstrated
PLA
most
efficient
agent,
followed
by
PCA,
whereas
phloretin,
at
lower
(2
mg/mL)
concentrations,
led
an
increase
growth
coli.
Various
modifications
agar
assay
did
not
reveal
antibacterial
studied
phytochemicals.
enhancing
effect
concentration
cooperation
with
shown.
These
findings
might
be
helpful
development
new
agents
treatment
skin
infections
wounds.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(16), P. 12802 - 12802
Published: Aug. 15, 2023
Anaphylaxis
is
a
life-threatening
or
even
fatal
systemic
hypersensitivity
reaction.
The
incidence
of
anaphylaxis
has
risen
at
an
alarming
rate
in
the
past
decades
majority
countries.
Generally,
most
common
causes
severe
are
medication,
foods
and
Hymenoptera
venoms.
Anaphylactic
reactions
characterized
by
activation
mast
cells
basophils
release
mediators.
These
express
variety
receptors
that
enable
them
to
respond
wide
range
stimulants.
Most
studies
focus
on
IgE-dependent
reactions.
cell
long
been
regarded
as
main
effector
involved
IgE-mediated
anaphylaxis.
This
paper
reviews
IgE-independent
anaphylaxis,
with
special
emphasis
cells,
basophils,
anaphylactic
mediators,
risk
factors,
triggers,
management.
