Depression in chronic kidney disease: particularities, specific mechanisms and therapeutic considerations, a narrative review

Behavioural Brain Research, Journal Year: 2025, Volume and Issue: 483, P. 115467 - 115467

Published: Feb. 7, 2025

Depression is highly prevalent during chronic kidney disease (CKD) with studies suggesting prevalence rates ranging from approximately one-quarter to half of CKD patients. and depression have a bidirectional relationship, each disorder aggravating the other, leading more complex challenging patient management. multifactorial associated increased risk adverse events hospitalization. We conducted narrative review experimental observational in animals humans, as well meta-analyses, explore specific mechanisms its treatment. In gut-brain axis central. leads an accumulation gut-derived uremic toxins. One key factor tryptophan-derived toxins like kynurenines or indoxyl sulfate, whose serum concentration increases progressively stage (up 100-fold 5), which plays important role mechanisms, by activating aryl hydrocarbon receptor, decreasing brain concentrations serotonin 40 %, increasing inflammation, via activation microglia astrocytes release TNFα, IL-6 NO. Randomized controlled found limited no benefits antidepressants for depressive symptoms hemodialysis Chronic relation toxin CKD, seems be but mechanism treatment resistance depression. Future research should consider inhibitors anti-inflammatory molecules potential therapeutic agents, improve prognosis

Language: Английский

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Insights into Health-Related Quality of Life of Kidney Transplant Recipients: A Narrative Review of Associated Factors

Kidney Medicine, Journal Year: 2025, Volume and Issue: 7(5), P. 100986 - 100986

Published: Feb. 25, 2025

Language: Английский

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Common mental health conditions and considerations in pediatric chronic kidney disease

Pediatric Nephrology, Journal Year: 2024, Volume and Issue: 39(10), P. 2887 - 2897

Published: March 8, 2024

Language: Английский

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Psychological Health of the Adolescent Transplant Recipient

Pediatric Transplantation, Journal Year: 2024, Volume and Issue: 28(6)

Published: Aug. 12, 2024

Solid organ transplant recipients experience a period of unique vulnerability during adolescence, when normative developmental changes intersect with health-related variables to influence psychological health.

Language: Английский

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Psychological distress in adults after pediatric kidney replacement therapy

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 20, 2024

Background There is limited information about psychological distress in adults who underwent kidney replacement therapy (KRT) during childhood. This study aimed to describe after KRT childhood comparison the Swiss general population and evaluate associations with sociodemographic clinical characteristics. Methods We sent a questionnaire 143 people from Pediatric Renal Registry (SPRR), were alive, over 18 years old, starting before age of years, being German speaking. measured using Brief Symptom Inventory (BSI-18) evaluated Global Severity Index (GSI-18), reflecting overall level distress, three subscales depression, somatization, anxiety. compared levels norm data used regression models identify Results Eighty persons mean 39 (SD 10.1) responded (response rate 56%). Overall, GSI-18 all BSI-18 similar among participants population. Unemployed reported higher somatization more likely experience distress. Participants psychotropic drugs (antidepressants or sleep medication) somatization. Conclusions Adults showed good long-term well-being. These results are encouraging underline favorable outcome these patients. So besides excellent somatic outcome, patients can achieve healthy life diagnosis chronic failure.

Language: Английский

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Social support and family resilience among Chinese people receiving maintenance hemodialysis: A polynomial regression and response surface analysis explaining psychological resilience

Applied Psychology Health and Well-Being, Journal Year: 2024, Volume and Issue: 16(4), P. 1905 - 1920

Published: June 25, 2024

Psychological resilience plays an important role in overcoming emotional distress among people receiving maintenance hemodialysis (MHD). This study aimed to investigate how social support and family interact influence psychological Chinese MHD. was a prospective longitudinal with three time points: baseline (T1), 3 months (T2), 6 (T3) later. A convenience sample of 252 participants (67.1% male; 57.6 ± 13.8 years age) from Zhejiang Province, China, who completed measures support, resilience, were further assessed for at T2 T3. Polynomial regression (PR) response surface analysis (RSA) used analyze the data. At all points, case agreement between combined effect both variables manifested as positive linear association resilience. Instead, baseline, disagreement, same negative relationship related The findings highlighted importance considering conjoint when developing interventions improve

Language: Английский

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Estudio comparativo de la resiliencia en pacientes de hemodiálisis y trasplante renal

Enfermería Nefrológica, Journal Year: 2024, Volume and Issue: 27(2), P. 127 - 132

Published: June 30, 2024

Introducción: Los pacientes con enfermedad renal crónica (ERC) en fase avanzada se ven sometidos a métodos de sustitución la función renal, como hemodiálisis y el trasplante renal. La resiliencia constituye un factor protector que propicia adaptación ante eventos adversos pueden surgir durante proceso cambio.Objetivos: Comparar sus dimensiones dos grupos ERC según su método por género, independientemente del grupo pertenencia.Material Método: El estudio fue transversal analítico utilizó escala validada Connor-Davidson 25 ítem. Las variables fueron los niveles dimensiones. Se incluyeron, además, género edad.Resultados: Participaron 88 hospital universitario Arnaldo Milián Castro, total 53 (52 %) masculino, 44 recibiendo mostraron valores medios superiores cuanto (M=79), persistencia, tenacidad autoeficacia (M=26) adaptabilidad redes apoyo (M=17); tanto destacaron control bajo presión (M=22); propósito (M=15) espiritualidad (M=9). Por masculino mostró promedios todas las variables. prueba U Man Whitney arrojó diferencias estadísticamente significativas para ambas formas agrupación.Conclusiones: Existen factores condicionan trasplante; así género.

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Psychological distress in adults after pediatric kidney replacement therapy

Pediatric Nephrology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

Abstract Background There is limited information about psychological distress in adults who underwent kidney replacement therapy (KRT) during childhood. This study aimed to describe after KRT childhood comparison the Swiss general population and evaluate associations with sociodemographic clinical characteristics. Methods We sent a questionnaire 143 people from Pediatric Renal Registry (SPRR), were alive, over 18 years old, started before age of years, German speakers. measured using Brief Symptom Inventory (BSI-18) evaluated Global Severity Index (GSI-18), reflecting overall level distress, three subscales: depression, somatization, anxiety. compared levels normal data used regression models identify Results Eighty persons mean 39 (SD 10.1) responded (response rate 56%). Overall, GSI-18 all subscales BSI-18 similar. Unemployed participants (25%) reported higher somatization more likely experience distress. Participants psychotropic drugs (14%) (10%), depression (13%) (9%). Conclusions Adults showed good long-term well-being. These results are encouraging underline favorable outcome these patients. So besides excellent somatic outcome, patients can achieve healthy life diagnosis chronic disease. Graphical abstract

Language: Английский

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Organ Transplant Recipients and Post-Traumatic Growth

Published: Jan. 1, 2024

Language: Английский

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Post-traumatic Distress in Adults with Congenital Heart Disease: Protective Factors and Clinical Implications

International Journal of Behavioral Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Abstract Background Due to various reasons explored in previous studies, adults with congenital heart disease (ACHD) are at risk of developing post-traumatic stress symptoms (PTSS). The aim this study is explore multiple potential psychosocial protective factors ACHD and understand their role different complexities (CHD) PTSS. Method This was part the “ABS-AHF” study, where 234 were recruited from November 2021 August 2022 a tertiary CHD care center. Data collected on PTSS (PDS), resilience (RS-13), sense coherence (SOC-L9), social support (F-SozU K-14). Results mean scores 70.55 + / − 12.31 [21–91] for resilience, 35.83 4.81 [15–60] (SOC), 4.30 0.79 [0.93–5] support. SOC (OR, .91; p = .024 [.84; 9.98]) .48; .001 [.29; 7.96]) shown reduce likelihood Low 2.40, .0248 [1.18; 5.18]) seems increase likelihood. Conclusion Integrating parents relatives early be an important resource. Parental childhood affects development which line related lower With regard SOC, brief manageable screening option personal resources available refer potentially vulnerable patients specialized care. Care offers should address coping styles life CHD. Offering multidisciplinary care, integrating patient’s network, education might provide way enhance outcomes, quality life, adherence ACHD.

Language: Английский

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