Terahertz Photons Improve Cognitive Functions in Posttraumatic Stress Disorder

Research, Journal Year: 2023, Volume and Issue: 6

Published: Jan. 1, 2023

Posttraumatic stress disorder (PTSD) is a serious psychosis leading to cognitive impairment. To restore functions for patients, the main treatments are based on medication or rehabilitation training but with limited effectiveness and strong side effects. Here, we demonstrate new treatment approach PTSD by using terahertz (THz) photons stimulating hippocampal CA3 subregion. We verified that this method can nonthermally function in rats vivo. After THz photon irradiation, rats’ recognitive index improved about 10% novel object recognition test, accuracy 100% shuttler box numbers identify target was 5 times lower Barnes maze rate of staying arm increased approximately 40% Y-maze test. Further experimental studies found (34.5 THz) irradiation could improve expression NR2B (increased nearly 40%) phosphorylated 50%). In addition, molecular dynamics simulations showed at frequency 34.5 mainly absorbed pocket glutamate receptors rather than molecules. Moreover, binding between molecules photons. This study offers nondrug, nonthermal regulate excitatory neurotransmitter (glutamate) NR2B. By increasing synaptic plasticity, it effectively improves animals PTSD, providing promising strategy NR2B-related disorders.

Language: Английский

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Nanotechnology for enhanced nose-to-brain drug delivery in treating neurological diseases

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 366, P. 519 - 534

Published: Jan. 11, 2024

Language: Английский

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Natural Polyphenolic Nanodots for Alzheimer's Disease Treatment

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(3)

Published: Nov. 28, 2023

Abstract The abnormal amyloid‐β accumulation is essential and obbligato in Alzheimer's disease pathogenesis natural polyphenols exhibit great potential as amyloid aggregation inhibitors. However, the poor metabolic stability, low bioavailability, weak blood–brain barrier crossing ability of polyphenol molecules fail to meet clinical needs. Here, a universal protocol prepare polyphenolic nanodots developed by heating aqueous solution without unacceptable additives. are able not only inhibit fibrillization trigger fibril disaggregation, but mitigate amyloid‐β‐plaque‐induced cascade impairments including normalizing oxidative microenvironment, altering microglial polarization, rescuing neuronal death synaptic loss, which results significant improvements recognition cognition deficits transgenic mice. More importantly, possess stronger antiamyloidogenic performance compared with small molecule, well penetrate barrier. excellent biocompatibility further guarantees for applications. It expected that provide an attractive paradigm support development therapeutics disease.

Language: Английский

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Lipid-mediated protein corona regulation with increased apolipoprotein A-I recruitment for glioma targeting

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 368, P. 42 - 51

Published: Feb. 21, 2024

Language: Английский

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Myricetin Oligomer Triggers Multi-Receptor Mediated Penetration and Autophagic Restoration of Blood-Brain Barrier for Ischemic Stroke Treatment

ACS Nano, Journal Year: 2024, Volume and Issue: 18(14), P. 9895 - 9916

Published: March 27, 2024

Restoration of blood-brain barrier (BBB) dysfunction, which drives worse outcomes ischemic stroke, is a potential target for therapeutic opportunities, whereas sealed BBB blocks the therapeutics entrance into brain, making protection strategy paradoxical. Post hypoxia/hypoglycemia provokes up-regulation transmembrane glucose transporters and iron due to multiple metabolic disorders, especially in brain endothelial cells. Herein, we develop myricetin oligomer-derived nanostructure doped with Ce bypass cointermediated by such as 1 (GLUT1), sodium/glucose cotransporters (SGLT1), transferrin(Tf) reporter (TfR). Moreover, it exhibits restoration capacity regulating expression tight junctions (TJs) through activation protective autophagy. The oligomers scaffold not only acts targeting moiety but prominent active entity that inherits all diverse pharmacological activities myricetin. suppression oxidative damage, M1 microglia activation, inflammatory factors makes multitasking nanoagent single component scaffold, domain curative components.

Language: Английский

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Interactions between nanoparticles and pathological changes of vascular in Alzheimer’s disease

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 207, P. 115219 - 115219

Published: Feb. 23, 2024

Language: Английский

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Recent Advances in Targeting Transition Metals (Copper, Iron, and Zinc) in Alzheimer’s Disease

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(12), P. 10916 - 10940

Published: May 29, 2024

Language: Английский

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SIRT5‐Mediated Desuccinylation of RAB7A Protects Against Cadmium‐Induced Alzheimer's Disease‐Like Pathology by Restoring Autophagic Flux

Advanced Science, Journal Year: 2024, Volume and Issue: 11(30)

Published: June 5, 2024

Cadmium (Cd) is a neurotoxic contaminant that induces cognitive decline similar to observed in Alzheimer's disease (AD). Autophagic flux dysfunction attributed the pathogenesis of AD, and this study aimed investigate effect autophagy on environmental Cd-induced AD progression underlying mechanism. Here, Cd exposure inhibited autophagosome-lysosome fusion impaired lysosomal function, leading defects autophagic clearance then APP accumulation nerve cell death. Proteomic analysis coupled with Ingenuity Pathway Analysis (IPA) identified SIRT5 as an essential molecular target Cd-impaired flux. Mechanistically, hampered expression SIRT5, thus increasing succinylation RAB7A at lysine 31 inhibiting activity, which contributed blockade. Importantly, overexpression led restoration blockade, alleviation Aβ deposition memory deficits, desuccinylation Cd-exposed FAD

Language: Английский

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Regulation of cerebral blood flow boosts precise brain targeting of vinpocetine-derived ionizable-lipidoid nanoparticles

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 11, 2024

Abstract Despite advances in active drug targeting for blood-brain barrier penetration, two key challenges persist: first, attachment of a ligand to the or carrier does not enhance its brain biodistribution; and second, many diseases are intricately linked microcirculation disorders that significantly impede accumulation within lesions even after they cross barrier. Inspired by neuroprotective properties vinpocetine, which regulates cerebral blood flow, we propose molecular library design centered on this class cyclic tertiary amine compounds develop self-enhanced brain-targeted nucleic acid delivery system. Our findings reveal that: (i) vinpocetine-derived ionizable-lipidoid nanoparticles efficiently breach barrier; (ii) have high gene-loading capacity, facilitating endosomal escape intracellular transport; (iii) their administration is safe with minimal immunogenicity prolonged use; (iv) potent pharmacologic brain-protective activity may synergize treatments as demonstrated male APP/PS1 mice.

Language: Английский

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Nanotechnology in the diagnostic and therapy for Alzheimer's disease

Biochimica et Biophysica Acta (BBA) - General Subjects, Journal Year: 2024, Volume and Issue: 1868(3), P. 130559 - 130559

Published: Jan. 6, 2024

Language: Английский

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