Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113604 - 113604
Published: March 1, 2025
Language: Английский
Biomaterials, Journal Year: 2024, Volume and Issue: 309, P. 122622 - 122622
Published: May 24, 2024
Language: Английский
Citations
7
Biomaterials, Journal Year: 2024, Volume and Issue: 312, P. 122749 - 122749
Published: Aug. 6, 2024
Language: Английский
Citations
7
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(31)
Published: May 23, 2024
Restricted by synaptic plasticity, dopamine receptor (DR) upregulation takes a long time to work. Moreover, the impact of blood-brain barrier (BBB) on delivery efficiency restricts development drugs. Taking inspiration from snuff bottles, convenient, fast-acting, and nonaddictive nasal drug system has been developed rapidly reshape balance transmitters. This optical magnetic response called CFs@DP, comprised carbonized MIL-100 (Fe) frameworks (CFs) domperidone (DP), which can enter brain via administration. Under dual stimulation near-infrared (NIR) irradiation catecholamine-induced complexation, CFs@DP disintegrates release iron ions DP, causing type 1 (D
Language: Английский
Citations
6
Theranostics, Journal Year: 2023, Volume and Issue: 13(14), P. 4781 - 4801
Published: Jan. 1, 2023
Hitchhiking, a recently developed bio-inspired cargo delivery system, has been harnessed for diverse applications.By leveraging the interactions between nanoparticles and circulatory cells or proteins, hitchhiking enables efficient navigation through vasculature while evading immune system clearance.Moreover, it allows targeted of nutrients to tissues, surveillance pathogen elimination.Various synthetic nanomaterials have facilitate with proteins.By combining advantages demonstrate several over conventional vectors, including enhanced stability optimized therapeutic efficacy.This review provides an overview general strategies hitchhiking, choices recent advances biomedical applications.
Language: Английский
Citations
15
ACS Chemical Neuroscience, Journal Year: 2024, Volume and Issue: 15(3), P. 593 - 607
Published: Jan. 12, 2024
Objective: Schisandrin B (Sch B) is a bioactive dibenzocyclooctadiene derizative that prevalent in the fruit of Schisandra chinensis. Numerous studies have demonstrated Sch has neuroprotective action by reducing oxidative stress and effectively preventing inflammation. It follows potential treatment for Alzheimer's disease (AD). However, drug's solubility, bioavailability, lower permeability blood–brain barrier (BBB) can all reduce its efficacy during therapy process. Therefore, this study constructed borneol-modified schisandrin micelles (Bor-Sch B-Ms), which increase brain targeting accurately delivering medications to brain, improving bioavailability. High therapeutic been achieved at pathological site. Methods: Bor-Sch B-Ms were prepared using thin film dispersion approach article. On one hand, observe effect borneol, we model vitro studied ability cross BBB. other distribution micelle drugs their related pharmacological effects on neuroinflammation, stress, neuronal damage through vivo administration mice. Results: In drug uptake bEnd.3 cells was increased borneol alteration surface nano micelles, implying promote N2a cells. This could result more medicines entering addition, revealed circulation time tissue significantly higher than those groups, making it suitable central nervous system diseases. Conclusion: As novel nanodrug delivery system, modified promising research prospects disease.
Language: Английский
Citations
5
Langmuir, Journal Year: 2024, Volume and Issue: 40(15), P. 7781 - 7790
Published: April 4, 2024
The distinct features of nanoparticles have provided a vast opportunity developing new diagnosis and therapy strategies for miscellaneous diseases. Although few nanomedicines are available in the market or translation stage, many important issues still unsolved. When entering body, nanomaterials will be quickly coated by proteins from their surroundings, forming corona on surface, so-called protein corona. Studies shown that has biological implications, particularly at vivo level. For example, they can promote immune system to rapidly clear these outer materials prevent playing designed role therapy. In this Perspective, techniques characterizing protein–nanoparticle interactions critically summarized. Effects nanoparticle properties environmental factors formation, which further regulate fate nanoparticles, highlighted discussed. Moreover, recent progress biomedical application corona-engineered is introduced, future directions yet challenging research area also briefly
Language: Английский
Citations
5
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(29)
Published: May 6, 2024
Orthotopic glioblastoma (GBM) has an aggressive growth pattern and complex pathogenesis, becoming one of the most common deadly tumors central nervous system (CNS). The emergence RNA therapies offers promise for treatment GBM. However, efficient precise delivery drugs to specific tumor cells in brain with high cellular heterogeneity remains ongoing. Here, a strategy is proposed regulate protein conformation through lipid nanoenvironments custom-design virus-mimicking nanoparticles (VMNs) excellent selective cell targeting capabilities, leading small interfering effective optimized VMNs not only retain ability cross blood-brain barrier release by lysosomal escape like natural viruses but also ensure enrichment GBM area. This study lays conceptual foundation custom design superior cell-selective capabilities opens up possibility CNS tumors.
Language: Английский
Citations
5
International Journal of Oral Science, Journal Year: 2024, Volume and Issue: 16(1)
Published: May 13, 2024
Abstract Oxidative stress is increasingly recognized as a major contributor to the pathophysiology of Alzheimer’s disease (AD), particularly in early stages disease. The multiplicity advantages stem cell transplantation make it fascinating therapeutic strategy for many neurodegenerative diseases. We herein demonstrated that human dental pulp cells (hDPSCs) mediated oxidative improvement and neuroreparative effects vitro AD models, playing critical roles regulating polarization hyperreactive microglia recovery damaged neurons. Importantly, these were reflected 10-month-old 3xTg-AD mice after single hDPSCs, with treated showing significant cognitive function neuropathological features. Mechanistically, antioxidant neuroprotective effects, well enhancements elicited by at least partially Nrf2 nuclear accumulation downstream enzymes expression through activation AKT-GSK3β-Nrf2 signaling pathway. In conclusion, our findings corroborated capacity hDPSCs reshape microenvironment both vivo which may be tremendous potential candidate
Language: Английский
Citations
5
Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(12), P. 5464 - 5478
Published: May 22, 2024
The neurovascular unit (NVU) is highly responsible for cerebral homeostasis and its dysfunction emerges as a critical contributor to Alzheimer's disease (AD) pathology. Hence, rescuing NVU might be viable approach AD treatments. Here, we fabricated self-regulated muti-functional nano-modulator (siR/PIO@RP) that can intelligently navigate damaged blood-brain barrier release therapeutical cargoes synergetic therapy. resulting siR/PIO@RP enables self-regulation of distribution in accordance with the physio/pathological state (low/high RAGE expression) target site via feedback loop. capable performing intricate tasks goes beyond capabilities single-target therapeutic agents utilized therapy, such reducing Aβ load, relieving neuroinflammation, alleviating NVU. Overall, current study provides proof concept normalizing holds promise means symptoms.
Language: Английский
Citations
5
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 21, 2025
Abstract Depression is a common psychiatric disorder, and monoamine‐based antidepressants as first‐line therapy remain ineffective in some patients. The synergistic modulation of neuroinflammation neuroplasticity could be major strategy for treating depression. In this study, an inflammation‐targeted microglial biomimetic system, PDA‐Mem@M, reported Microglial membrane‐coated nanoparticles penetrate the blood‐brain barrier facilitate targeting. Subsequently, owing to excellent free radical‐scavenging capacity, PDA‐Mem@M attenuate brain inflammatory microenvironment. After on‐demand release from nanoparticles, memantine increases expression brain‐derived neurotrophic factors reverses loss synaptic dendritic spines. Further, vivo studies demonstrate that effectively alleviate depression‐like behaviors greater extent than or polydopamine (PDA) monotherapy. This strategy, with satisfactory biosafety strong anti‐inflammatory plasticity restoration effects, conducive advances depression therapy.
Language: Английский
Citations
0