Molecular insights of exercise therapy in disease prevention and treatment

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: May 29, 2024

Despite substantial evidence emphasizing the pleiotropic benefits of exercise for prevention and treatment various diseases, underlying biological mechanisms have not been fully elucidated. Several attributed to signaling molecules that are released in response by different tissues such as skeletal muscle, cardiac adipose, liver tissue. These molecules, which collectively termed exerkines, form a heterogenous group bioactive substances, mediating inter-organ crosstalk well structural functional tissue adaption. Numerous scientific endeavors focused on identifying characterizing new mediators with properties. Additionally, some investigations molecular targets exerkines cellular cascades trigger adaption processes. A detailed understanding tissue-specific downstream effects is crucial harness health-related mediated improve targeted programs health disease. Herein, we review current vivo exerkine-induced signal transduction across multiple target highlight preventive therapeutic value exerkine diseases. By aspects research, provide comprehensive overview (i) underpinnings secretion, (ii) receptor-dependent receptor-independent adaption, (iii) clinical implications these disease treatment.

Language: Английский

---

Altered atlas of exercise-responsive microRNAs revealing miR-29a-3p attacks armored & cold tumors and boosts anti-B7-H3 therapy

Research, Journal Year: 2025, Volume and Issue: 8

Published: Jan. 1, 2025

Increasing evidence has shown that physical exercise remarkably inhibits oncogenesis and progression of numerous cancers exercise-responsive microRNAs (miRNAs) exert a marked role in exercise-mediated tumor suppression. In this research, expression prognostic values miRNAs were examined breast cancer (BRCA) further pan-cancer types. addition, multiple independent public in-house cohorts, vitro assays involving multiple, macrophages, fibroblasts, cells, vivo models utilized to uncover the tumor-suppressive roles miR-29a-3p cancers. Here, we reported was miRNA, which lowly expressed tissues associated with unfavorable prognosis BRCA. Mechanistically, targeted cells down-regulate B7 homolog 3 (B7-H3) expression. Single-cell RNA sequencing (scRNA-seq) cytometry by time-of-flight (CyTOF) demonstrated attacked armored cold tumors, thereby shaping an immuno-hot microenvironment (TME). Translationally, liposomes developed loaded (lipo@miR-29a-3p), lipo@miR-29a-3p exhibited promising antitumor effects mouse model great biocompatibility. conclusion, uncovered is critical tumors inhibiting B7-H3 Thus, restoration could be alternative strategy for therapy.

Language: Английский

---

SPRY1 regulates macrophage M1 polarization in skin aging and melanoma prognosis

Translational Oncology, Journal Year: 2025, Volume and Issue: 54, P. 102331 - 102331

Published: Feb. 28, 2025

Language: Английский

---

Critical analysis of descriptive microRNA data in the translational research on cardioprotection and cardiac repair: lost in the complexity of bioinformatics

Basic Research in Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

---

Role and mechanisms of exercise therapy in enhancing drug treatment for glioma: a review

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 30, 2025

Gliomas, particularly glioblastoma (GBM), are among the most aggressive and challenging brain tumors to treat. Although current therapies such as chemotherapy, radiotherapy, targeted treatments have extended patient survival some extent, their efficacy remains limited is often accompanied by severe side effects. In recent years, exercise therapy has gained increasing attention an adjunctive treatment in clinical research settings. Exercise not only improves patients' physical function cognitive abilities but may also enhance of conventional drug modulating immune system, suppressing inflammatory responses, improving blood-brain barrier permeability. This review summarizes potential mechanisms glioma treatment, including enhancing surveillance through activation natural killer (NK) cells T cells, penetration function. Additionally, studies suggest that can synergize with chemotherapy immunotherapy, outcomes while reducing drug-related application patients still exploratory phase, existing evidence indicates its significant value approach, become a new standard future.

Language: Английский

---

Recent advances of the Ephrin and Eph family in cardiovascular development and pathologies

iScience, Journal Year: 2024, Volume and Issue: 27(8), P. 110556 - 110556

Published: July 20, 2024

Erythropoietin-producing hepatoma (Eph) receptors, comprising the largest family of receptor tyrosine kinases (RTKs), exert profound influence on diverse biological processes and pathological conditions such as cancer. Interacting with their corresponding ligands, erythropoietin-producing interacting proteins (Ephrins), Eph receptors regulate crucial events like embryonic development, tissue boundary formation, tumor cell survival. In addition to well-established roles in development cancers, emerging evidence highlights pivotal contribution Ephrin/Eph cardiovascular physiology pathology. Studies have elucidated involvement atherosclerosis, postnatal angiogenesis, and, more recently, cardiac fibrosis calcification, suggesting a promising avenue for therapeutic interventions diseases. There remains need comprehensive synthesis collective impact context. By exploring intricate interactions between ephrins, system, this review aims provide holistic understanding potential health

Language: Английский

---

Deciphering and Targeting the ESR2–miR-10a-5p–BDNF Axis in the Prefrontal Cortex: Advancing Postpartum Depression Understanding and Therapeutics

Research, Journal Year: 2024, Volume and Issue: 7

Published: Jan. 1, 2024

Postpartum depression (PPD) represents a important emotional disorder emerging after childbirth, characterized by its complex etiology and challenging management. Despite extensive preclinical clinical investigations underscoring the role of estrogen fluctuations receptor genes in PPD, precise mechanisms underpinning this condition have remained elusive. In our present study, animal behavioral studies elucidated tight link between aberrant expression ESR2, miR-10a-5p, BDNF prefrontal cortex mice exhibiting postpartum depressive-like behavior, shedding light on potential molecular pathways involved. Integrating bioinformatics, vivo, cell transfection methodologies has unraveled intricate interplay BDNF. We identified ESR2 as negative transcription factor that down-regulates miR-10a transcription, while miR-10a-5p serves regulator suppresses expression. This triad contributes to pathogenesis PPD affecting synaptic plasticity, evidenced alterations synapse-related proteins (e.g., SYP, SYN, PSD95) glutamate Additionally, primary neuron culture confirmed critical roles maintaining neuronal growth morphology. Therapeutic interventions, including stereotactic intranasal administration antagomir or BDNF, demonstrated significant treating highlighting therapeutic implications targeting transcriptional regulatory interactions Our findings endorse hypothesis gene activity are pivotal stressors risk factors for central nervous system functionality precipitating depressive behaviors postpartum.

Language: Английский

---

tRF-AspGTC promotes intracranial aneurysm formation by controlling TRIM29-mediated galectin-3 ubiquitination

Research, Journal Year: 2024, Volume and Issue: 8

Published: Dec. 18, 2024

Transfer RNA-derived small RNAs, a recently identified class of noncoding play crucial role in regulating gene expression and are implicated cerebrovascular diseases. However, the specific biological roles mechanisms transfer RNAs intracranial aneurysms (IAs) remain unclear. In this study, we that RNA-Asp-GTC derived fragment (tRF-AspGTC) is highly expressed IA tissues both humans mice. tRF-AspGTC promotes formation by facilitating phenotypic switching vascular smooth muscle cells, increasing matrix metalloproteinase 9 expression, inducing oxidative stress inflammatory responses. Mechanistically, binds to galectin-3, inhibiting tripartite motif 29-mediated ubiquitination stabilizing galectin-3. This stabilization activates toll-like receptor 4/MyD88/nuclear factor kappa B pathway, further driving inflammation. Clinically, circulating exosomal demonstrates strong diagnostic efficacy for IAs as an independent risk occurrence. These findings highlight potential promising biomarker therapeutic target IAs.

Language: Английский

---

RNA-mediated epigenetic regulation in exercised heart: Mechanisms and opportunities for intervention

Molecular Aspects of Medicine, Journal Year: 2024, Volume and Issue: 97, P. 101274 - 101274

Published: April 22, 2024

Language: Английский

---

Aerobic exercise training attenuates ischemia-reperfusion injury in mice by decreasing the methylation level of METTL3-associated m6A RNA in cardiomyocytes

Life Sciences, Journal Year: 2024, Volume and Issue: 361, P. 123294 - 123294

Published: Dec. 5, 2024

Language: Английский

---