Low-Friction Soft Robots for Targeted Bacterial Infection Treatment in Gastrointestinal Tract

Cyborg and Bionic Systems, Journal Year: 2024, Volume and Issue: 5

Published: Jan. 1, 2024

Untethered and self-transformable miniature robots are capable of performing reconfigurable deformation on-demand locomotion, which aid the traversal toward various lumens, bring revolutionary changes for targeted delivery in gastrointestinal (GI) tract. However, viscous non-Newtonian liquid environment plicae gastricae obstacles severely hamper high-precision actuation payload delivery. Here, we developed a low-friction soft robot by assembly densely arranged cone structures grafting hydrophobic monolayers. The magnetic orientation encoded can move multiple modes, with substantially reduced drag, terrain adaptability, improved motion velocity across liquids. Notably, stiffness be reversibly controlled magnetically induced hardening, enabling on-site scratching destruction antibiotic-ineradicable polymeric matrix biofilms low-frequency field. Furthermore, magnetocaloric effect utilized to eradicate bacteria under high-frequency alternating To verify potential applications inside body, clinical imaging-guided platforms were vision-based control robots. show their high perform bacterial infection therapy lumens body.

Language: Английский

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Wearable and Implantable Soft Robots

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(20), P. 11585 - 11636

Published: Oct. 11, 2024

Soft robotics presents innovative solutions across different scales. The flexibility and mechanical characteristics of soft robots make them particularly appealing for wearable implantable applications. scale level invasiveness required depend on the extent human interaction. This review provides a comprehensive overview robots, including applications in rehabilitation, assistance, organ simulation, surgical tools, therapy. We discuss challenges such as complexity fabrication processes, integration responsive materials, need robust control strategies, while focusing advances actuation sensing mechanisms, techniques. Finally, we future outlook, highlighting key proposing potential solutions.

Language: Английский

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Bio‐Integrated Microrobots: Fabrication, Actuation and Biomedical Applications

Published: March 13, 2025

ABSTRACT Bio‐integrated microrobots (BIMs), which are fabricated with biofriendly materials, biological units (e.g. cells or biomolecules), cell‐material hybrids have emerged as a promising technology for minimally invasive biomedicine. The diminutive size and flexible structures enable BIMs to navigate within narrow, deep, challenging‐to‐reach in vivo regions, performing biopsy, diagnostic, drug delivery, therapeutic functions minimal invasiveness. However, the clinical deployment of is highly orchestrated task that requires consideration material properties, structural design, locomotion, observation, outcomes, side effects on tissues, etc. In this review, we review discuss latest advances bio‐integrated microrobot domain, evaluating various methods associated fabrication, actuation, implementation biomedical BIMs. By comparing advantages shortcomings these techniques, highlights challenges future trends intelligent microrobots, huge potential

Language: Английский

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Multi-Section Magnetic Soft Robot with Multirobot Navigation System for Vasculature Intervention

Cyborg and Bionic Systems, Journal Year: 2024, Volume and Issue: 5

Published: Jan. 1, 2024

Magnetic soft robots have recently become a promising technology that has been applied to minimally invasive cardiovascular surgery. This paper presents the analytical modeling of novel multi-section magnetic robot (MS-MSR) with multi-curvature bending, which is maneuvered by an associated collaborative multirobot navigation system (CMNS) actuation and ultrasound guidance targeted for intravascular intervention. The kinematic dynamic analysis MS-MSR’s telescopic motion performed using optimized Cosserat rod model considering effect external heterogeneous field, generated mobile manipulator adapt complex steering scenarios. Meanwhile, extracorporeal exploited track robot’s distal tip realize closed-loop control. We also conduct quadratic programming-based optimization scheme synchronize multi-objective task-space CMNS null-space projection. It allows formulation comprehensive controller priority collaboration. Experimental results demonstrate proposed can be successfully navigated within multi-bifurcation environment shape error 3.62 ± 1.28 ∘ 1.08 0.45 mm under through in vitro ultrasound-guided vasculature interventional tests.

Language: Английский

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Programming ferromagnetic soft materials for miniature soft robots: Design, fabrication, and applications

Journal of Material Science and Technology, Journal Year: 2024, Volume and Issue: 219, P. 271 - 287

Published: Sept. 14, 2024

Language: Английский

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A radial micro-vibration system for reducing friction of passive interventional guidewire

Journal of Applied Physics, Journal Year: 2025, Volume and Issue: 137(1)

Published: Jan. 2, 2025

Endovascular guidewire interventional surgery is an effective treatment for vascular diseases. However, due to factors, such as blood viscosity and complex morphology, the interfered by strong varying resistance when moving in lesion’s vasculature. This greatly affects efficiency safety of clinical operation. Here, we develop a novel system that applies ultrasonic micro-amplitude vibration conventional passive studying drag reduction effect under multiple factors. The mainly composed sandwich-type transducer step-type horn concentrating unidirectional energy micro-vibration. Subsequently, comparative experiments are designed verify effectiveness this reduction. Through multifactorial interactions, study friction law microvibration-assisted method on optimal parameter combinations. results show varies with amplitude–frequency response curve. An ultrasound amplitude simulated vessel bending angle were most significant Only frequency interacted shape. Finally, using resonance maximum drive vibration, rate can be obtained, up 85.2%. expected have important applications procedures.

Language: Английский

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Advances in Shape‐Memory Polymers and Composites for Biomedical Device Applications

Advanced Engineering Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Over the past two decades, remarkable advancements have been achieved in stimulus‐responsive shape‐memory polymers (SMPs), which exhibit desirable properties such as characteristics, deformability, and biocompatibility, while responding to external stimuli. The development of polymer composites (SMPCs) leads high recovery forces novel functionalities, including electrical actuation, magnetic biocompatibility. enhanced remotely controllable functionality further expand application SMPs biomedical areas, surgical applications for replacing handheld instruments drug delivery systems. In this review, device SMPCs are focused on their recent bone tissue scaffolds, lumen stents, carriers examined. Furthermore, bottlenecks challenges encountered by devices elucidated. future trend is also discussed, aiming provide valuable insights broadening fields.

Language: Английский

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A Shared Control Method of Multiobjective Motion Fusion for Surgical Robot

Advanced Intelligent Systems, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Shared control combines human intelligence with autonomous algorithms, demonstrating potential for enhancing the intricate and dynamic operational capabilities of robots. In robotic surgery, shared can integrate functions into master–slave control, which enables surgeons to receive certain assistance while maintaining operation. Such a system must handle multiple types dynamically changing motion tasks, instance, trajectory tracking, obstacle avoidance, spatial constraint, safety guarantee. This article proposes an innovative method based on multiobjective fusion (MoMF) by integrating objective controllers mode. addition, state feedback mechanism prediction evaluation model is developed balance inputs different objectives. Further, priority partition function designed overcome conflicts between proposed method, be added or removed as needed. The theoretical stability MoMF proved. As example, controller that considers four objectives surgical cutting operation demonstrate practicability this method. Finally, feasibility effectiveness are validated simulations prosthesis experiments.

Language: Английский

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Navigating microalgal biohybrids through confinements with magnetic guidance

Matter, Journal Year: 2025, Volume and Issue: unknown, P. 102052 - 102052

Published: March 1, 2025

Language: Английский

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Robotic‐Assisted Endovascular Embolization: Progress and Future Perspectives

Published: March 22, 2025

ABSTRACT Minimally invasive transcatheter embolization is a widely utilized in interventional radiology to occlude blood vessels for treating range of diseases and vascular injuries. Various embolic agents, such as metallic coils, microspheres, liquid‐based are delivered the target site effectively block flow achieve vessel occlusion. However, precise selective deployment these agents into lesions remains challenge due limited steerability maneuverability current catheter systems. This review provides comprehensive overview recent advancements delivery devices, with particular focus on emerging robot‐assisted technologies. It also discusses key challenges associated materials explores future trends shaping field.

Language: Английский

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