BuyangHuanwu Decoction alleviates Endothelial Cell Apoptosis and Coronary Microvascular Dysfunction via Regulation of the MAPKK4/p38 Signaling Axis DOI Creative Commons

Xing Chang,

Dan Wu, Xin Gao

et al.

International Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 21(13), P. 2464 - 2479

Published: Jan. 1, 2024

MAPKK4 has been implicated in the pathological mechanisms underlying myocardial and vascular injury, specifically influencing endothelial cell damage programmed death via subcellular pathways. Nevertheless, regulatory role of coronary microvascular injury following infarction remains unconfirmed, exploration targeted mitochondrial protective therapeutic agents unaddressed. In light this gap, we established a gene-modified mouse model ischemia-reperfusion employed Buyang Huanwu decoction (BYHW), traditional cardiovascular formula, to assess its efficacy treating post-ischemia-reperfusion. The study aimed elucidate mechanism by which BYHW mitigates induced through attenuation apoptosis. Experimental outcomes revealed that high-dose significantly ameliorated post-ischemia-reperfusion, restoring structural integrity microvasculature reducing inflammation oxidative stress. Contrarily, transgenic mice overexpressing MAPKK4, intervention failed attenuate To further investigate, simulated hypoxia/reoxygenation cells using MAPKK4-related cellular gene modification model. results indicated attenuates inflammatory enhances viability hypoxic stress, inhibiting apoptosis pathway. However, overexpression MAPKK4/p38 negated effects BYHW, showing no impact on stress under conditions. Molecular interaction studies confirmed active components Astragaloside IV Ligustrazine, interact with MAPKK4/P38 axis.

Language: Английский

Heat shock proteins as hallmarks of cancer: insights from molecular mechanisms to therapeutic strategies DOI Creative Commons

Wei‐Fang Zuo,

Qiwen Pang, Xinyu Zhu

et al.

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: Sept. 4, 2024

Language: Английский

Citations

13
Sc-Catalyzed Asymmetric [2 + 2] Annulation of 2-Alkynylnaphthols with Dienes to Access Cyclobutene Frameworks DOI
Ke Xu, Heping Li,

Yan‐Ling Ji

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: 27(4), P. 1006 - 1011

Published: Jan. 16, 2025

Herein, we introduce a scandium-catalyzed synthetic strategy that provides access to diverse and functionalized array of cyclobutene frameworks adorned with quaternary carbon center. This approach broadens the repertoire 2-alkynylnaphthols alkenes, offering versatile platform for construction complex molecular architectures. The asymmetric catalytic [2 + 2] cycloaddition reaction demonstrates wide substrate scope an impressive functional group tolerance, yielding products high efficiency, up 97% yield, excellent enantiomeric excess 97%. simplicity scaling this process, coupled ease converting these into variety substituted products, significantly enhances utility method.

Language: Английский

Citations

1
Multifaceted roles of Galectins: from carbohydrate binding to targeted cancer therapy DOI Creative Commons
Nan Zhang, Qiao Liu, Dan Wang

et al.

Biomarker Research, Journal Year: 2025, Volume and Issue: 13(1)

Published: March 25, 2025

Abstract Galectins play pivotal roles in cellular recognition and signaling processes by interacting with glycoconjugates. Extensive research has highlighted the significance of context cancer, aiding identification biomarkers for early detection, personalized therapy, predicting treatment responses. This review offers a comprehensive overview structural characteristics, ligand-binding properties, proteins Galectins. We delve into their biological functions examine across various cancer types. Galectins, characterized conserved carbohydrate domain (CRD), are divided prototype, tandem-repeat, chimera types based on configurations. Prototype contain single CRD, tandem-repeat two distinct CRDs linked peptide, chimera-type Galectin-3 features unique arrangement. The capacity to engage multivalent interactions allows them regulate variety pathways, thereby affecting cell fate function. In contribute tumor transformation, angiogenesis, immune evasion, metastasis, making critical targets therapeutic intervention. discusses multifaceted progression explores current advancements development Galectin-targeted therapies. also address challenges future directions integrating Galectin clinical practice enhance outcomes. brief, understanding complex biology opens new avenues strategies. Continued pathological is essential developing effective carbohydrate-based treatments improving interventions patients. Graphical

Language: Английский

Citations

0
Diverse synthesis of bridged bicyclo[3.2.1]octa-2,6-diene and tricyclo[3.2.1.0²,7] oct-3-ene frameworks via stepwise cascade reactions DOI

Z. Zheng,

Mu-Qiu Chen,

Jing Zhou

et al.

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 111202 - 111202

Published: April 1, 2025

Language: Английский

Citations

0
BuyangHuanwu Decoction alleviates Endothelial Cell Apoptosis and Coronary Microvascular Dysfunction via Regulation of the MAPKK4/p38 Signaling Axis DOI Creative Commons

Xing Chang,

Dan Wu, Xin Gao

et al.

International Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 21(13), P. 2464 - 2479

Published: Jan. 1, 2024

MAPKK4 has been implicated in the pathological mechanisms underlying myocardial and vascular injury, specifically influencing endothelial cell damage programmed death via subcellular pathways. Nevertheless, regulatory role of coronary microvascular injury following infarction remains unconfirmed, exploration targeted mitochondrial protective therapeutic agents unaddressed. In light this gap, we established a gene-modified mouse model ischemia-reperfusion employed Buyang Huanwu decoction (BYHW), traditional cardiovascular formula, to assess its efficacy treating post-ischemia-reperfusion. The study aimed elucidate mechanism by which BYHW mitigates induced through attenuation apoptosis. Experimental outcomes revealed that high-dose significantly ameliorated post-ischemia-reperfusion, restoring structural integrity microvasculature reducing inflammation oxidative stress. Contrarily, transgenic mice overexpressing MAPKK4, intervention failed attenuate To further investigate, simulated hypoxia/reoxygenation cells using MAPKK4-related cellular gene modification model. results indicated attenuates inflammatory enhances viability hypoxic stress, inhibiting apoptosis pathway. However, overexpression MAPKK4/p38 negated effects BYHW, showing no impact on stress under conditions. Molecular interaction studies confirmed active components Astragaloside IV Ligustrazine, interact with MAPKK4/P38 axis.

Language: Английский

Citations

3