Decoding the regulatory roles of circular RNAs in cardiac fibrosis DOI Creative Commons

Qianhui You,

Jiajing Yu,

Rongfang Pan

et al.

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 11, P. 115 - 130

Published: Dec. 9, 2024

Cardiovascular diseases (CVDs) are the primary cause of death globally. The evolution nearly all types CVDs is characterized by a common theme: emergence cardiac fibrosis. precise mechanisms that trigger fibrosis still not completely understood. In recent years, type non-coding regulatory RNA molecule known as circular RNAs (circRNAs) has been reported. These molecules produced during back splicing and possess significant biological capabilities, such regulating microRNA activity, serving protein scaffolds recruiters, competing with mRNA, forming circR-loop structures to modulate transcription, translating polypeptides. Furthermore, circRNAs exhibit substantial abundance, notable stability, specificity tissues, cells, time, endowing them potential biomarkers, therapeutic targets, agents. CircRNAs have garnered growing interest in field CVDs. Recent investigations into involvement yielded encouraging findings. This study aims provide concise overview existing knowledge about roles

Language: Английский

Circular RNAs modulate cell death in cardiovascular diseases DOI Creative Commons
Rongfang Pan,

Christine X. Koo,

Wenyuan Su

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: May 2, 2025

Language: Английский

Citations

0
Progress of nanomaterials in the treatment of ischemic heart disease DOI
Nan Li, Yu Chen, Xue Xia

et al.

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review constructs a dynamic and progressive pathological framework for the development of IHD, from MI to IRI eventually HF, systematically revealing multidimensional therapeutic strategies nanomaterials.

Language: Английский

Citations

0
Decoding the regulatory roles of circular RNAs in cardiac fibrosis DOI Creative Commons

Qianhui You,

Jiajing Yu,

Rongfang Pan

et al.

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 11, P. 115 - 130

Published: Dec. 9, 2024

Cardiovascular diseases (CVDs) are the primary cause of death globally. The evolution nearly all types CVDs is characterized by a common theme: emergence cardiac fibrosis. precise mechanisms that trigger fibrosis still not completely understood. In recent years, type non-coding regulatory RNA molecule known as circular RNAs (circRNAs) has been reported. These molecules produced during back splicing and possess significant biological capabilities, such regulating microRNA activity, serving protein scaffolds recruiters, competing with mRNA, forming circR-loop structures to modulate transcription, translating polypeptides. Furthermore, circRNAs exhibit substantial abundance, notable stability, specificity tissues, cells, time, endowing them potential biomarkers, therapeutic targets, agents. CircRNAs have garnered growing interest in field CVDs. Recent investigations into involvement yielded encouraging findings. This study aims provide concise overview existing knowledge about roles

Language: Английский

Citations

0