Early‐Life Adversity Predicts Markers of Aging‐Related Neuroinflammation, Neurodegeneration, and Cognitive Impairment in Women

Annals of Neurology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Objective Despite the overwhelming evidence for profound and longstanding effects of early‐life stress (ELS) on inflammation, brain structure, molecular aging, its impact human aging risk neurodegenerative disease is poorly understood. We examined ELS severity in interaction with age blood‐based markers neuroinflammation neurodegeneration, volumes, cognitive function middle‐aged women. Methods recruited 179 women (aged 30–60 years) without exposure before onset puberty. Using Simoa technology, we assessed including serum concentrations glial fibrillary acidic protein (GFAP) neurofilament light chain (NfL). further obtained T1‐weighted T2‐weighted magnetic resonance images to assess volumes performance sensitive early impairments associated development dementia, using Cambridge Neuropsychological Automated Test Battery. used generalized additive models examine nonlinear these outcomes. Results Analyses revealed significant NfL GFAP concentrations, total subcortical gray matter volume loss, increased third ventricular volume, impairment. Interpretation These findings suggest that profoundly exacerbates peripheral, neurostructural, aging. Our results are critical novel prevention strategies target developmental mitigate aging‐related neurological diseases. ANN NEUROL 2025

Language: Английский

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Rumination and altered reactivity to sensory input as vulnerability factors for developing post-traumatic stress symptoms among adults with autistic traits

CNS Spectrums, Journal Year: 2024, Volume and Issue: 29(2), P. 119 - 125

Published: Jan. 15, 2024

Recent literature has suggested that individuals with autism spectrum disorder (ASD) or autistic traits (ATs) would be more likely to encounter traumatic events in their lifetime and develop post-traumatic stress (PTSD). However, the nature of this relationship not yet been fully elucidated. The aims study were evaluate between AT PTSD investigate which specific dimension was associated trauma stress-related symptoms.

Language: Английский

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The protective role of self compassion in trauma recovery and its moderating impact on post traumatic symptoms and post traumatic growth

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 9, 2025

Language: Английский

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Existential Anxiety of Nurses in the COVID‐19‐Virus Units and Its Relation With Resilience and Posttraumatic Growth

Health Science Reports, Journal Year: 2025, Volume and Issue: 8(3)

Published: March 1, 2025

The study aimed to investigate the relationship between existential anxiety, posttraumatic growth, and resilience in nurses working COVID-19units. was a descriptive-analytical study. researchers conducted on 224 COVID-19units of four hospitals affiliated with Kerman University Medical Sciences Southeast Iran from 2021 2020 census method. data were collected using demographic questionnaire, Masoudi Sani et al.'s anxiety Conner-Davidson scale, growth inventory. mean age 30.88% ± 6.53% 76.3% them female. results showed there negative significant correlation (p < 0.001, r = -0.38) but no statistically resilience, > 0.05). Regression analysis indicated 0.28), Posttraumatic 0.20). There difference score, age, sex, education level, score emergency personnel significantly higher than other departments. demonstrated that scores moderate. suggest educational interventional measures improve reduce among nurses.

Language: Английский

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Resilience Amid Adversity: A Qualitative Narrative Study of Childhood Sexual Abuse Among Bangladeshi Transgender Individuals

International Journal of Environmental Research and Public Health, Journal Year: 2025, Volume and Issue: 22(4), P. 615 - 615

Published: April 15, 2025

Childhood sexual abuse (CSA) is a prevalent form of violence against children, associated with profound negative impacts on survivors’ health and well-being. In Bangladesh, sociocultural economic barriers hinder CSA prevention intervention, particularly for vulnerable populations such as transgender individuals. This study explores the experiences among Bangladeshi individuals, focusing their coping mechanisms resilience-building strategies. A qualitative narrative approach was employed, using life story-telling interviews four survivors, data were analyzed thematically. The findings reveal significant challenges, including social exclusion, humiliation, lack family support. Participants reported experiencing physical injuries, mental trauma, loss trust due to CSA, while conservative nature society often prevented them from disclosing or seeking healthcare. These exacerbate inequalities gender-minority children. Despite these adversities, participants described engaging in strategies self-care, personal development, advocacy, efforts derive meaning experiences, highlighting perceived importance provides insights into unique survivors Bangladesh calls towards gender-inclusive education, support, further research address CSA-related adversity, encourage disclosure, promote equity groups.

Language: Английский

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Posttraumatic Growth, Maladaptive Cognitive Schemas and Psychological Distress in Individuals Involved in Road Traffic Accidents—A Conservation of Resources Theory Perspective

Healthcare, Journal Year: 2023, Volume and Issue: 11(22), P. 2959 - 2959

Published: Nov. 14, 2023

Road traffic accidents can have profound psychological impacts on the individuals involved, encompassing both negative distress and positive growth. This study, guided by conservation of resources (COR) theory, investigates intricate relationship between posttraumatic growth (PTG), maladaptive cognitive schemas, in involved road accidents. PTG reflects an individual's ability to derive changes from adversity, while schemas represent patterns. Using a 122 sample accidents, we examined direct indirect effects within this complex network. Our findings reveal significant (β = 0.101, p 0.02). Particularly noteworthy are mediated emphasizing role impaired autonomy perceived performance deficiencies 0.102, 0.05). suggests that experiencing higher levels may indirectly experience greater through these schemas. study not only advances our understanding consequences but also aligns with self-determination competence as fundamental needs. Individuals undergo shifts perspective following trauma, which results support. Recognizing nuanced PTG, is crucial for tailoring interventions support systems As coexist distress, should foster adaptive addressing promote resilience face traumatic events.

Language: Английский

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Posttraumatic Stress Disorder (PTSD), psychological flexibility and psychological adjustment problems: Turkish validation of the PTSD checklist for short form DSM‐5 (PCL‐5-S)

European Journal of Trauma & Dissociation, Journal Year: 2024, Volume and Issue: 8(1), P. 100381 - 100381

Published: Jan. 7, 2024

Language: Английский

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Biological Correlates of Post-Traumatic Growth (PTG): A Literature Review

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(2), P. 305 - 305

Published: Feb. 10, 2023

Since the beginning of medical science, much research have focused on psychopathological effects traumatic experiences. Despite in past centuries scientific literature mental health has been mainly harmful occurrences, more recently idea “post-traumatic growth” emerged, basis a growing interest characteristics resilience and possible positive consequences trauma. In this framework, increasing attention is now being paid to psychological meaning PTG, with consistent number epidemiological studies subject, but limited neurobiological correlates or eventual biomarkers condition. The present work aimed summarize review available evidence PTG their clinical meaning. Results highlighted variety biochemical differences between non-PTG individuals, partially corroborating findings from earlier post-traumatic stress disorder (PTSD). However, although promising, field are still too additional experiences needed order gain better understanding subject.

Language: Английский

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Social Inquiry into Well-Being, Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 1, 2023

This research focuses on the assessment of post-traumatic growth (PTG) in an ongoing crisis situation – namely, war Ukraine. was designed as a crosssectional correlational study and conducted 6 months after beginning Russian invasion The authors focused following sociodemographic aspects: gender, age, marital status, number children, place current residence (either within or outside Ukraine), subjective evaluation financial state, satisfaction with living conditions, employment status. Personal life-experiences traumatic events were assessed using Life Events Checklist (LEC-5); PTG PostTraumatic Growth Inventory (PTGI). included 706 participants (age M = 32.1); 155 males 541 females. Using one- two-way ANOVA, we answered questions: To what extent do individuals war-torn areas exhibit indications PTG? Can variables serve reliable predictors How levels differ between residing Ukraine those abroad? What is relationship war-related trauma? It found that people moderate PTG. Women are more prone to than men; younger older show higher PTG, while middle-aged lower levels; security increases Presence personal strength, possibilities for new strategies. Trauma exposure during does not increase

Language: Английский

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Organizational compassion and employee adversarial growth under various job control

Frontiers in Psychology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 20, 2023

Introduction Adversity can bring stress and challenges to an individual's life, but many people who experience adversity also have positive changes. The formative mechanisms of individual adversarial growth received widespread attention. Methods A two-wave survey 421 Chinese employees experienced during the COVID-19 epidemic was used examine influence mechanism organizational compassion on moderating effect job control. Results Through correlation analysis, hierarchical regression, bootstrap test cross-sectional data, study has verified compassion, work passion, self-worth, form a chain mediating relation. Job control negatively moderates indirect through passion that is, employee self-worth is more pronounced under lower Discussion Organizational increase by enhancing their self-worth. Organizations should pay attention those with are in adversity, they likely benefit from organization's care compassion.

Language: Английский

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