Weaning stress and intestinal health of piglets: A review

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Nov. 24, 2022

Weaning is considered to be one of the most critical periods in pig production, which related economic benefits farms. However, actual many piglets are often subjected weaning stress due sudden separation from sow, changes diet and living environment, other social challenges. causes morphology function small intestine piglets, disrupts digestion absorption capacity, destroys intestinal barrier function, ultimately leads reduced feed intake, increased diarrhea rate, growth retardation. Therefore, correctly understanding effects on health have important guiding significance for nutritional regulation injury caused by stress. In this review, we mainly reviewed aspects development, thereby providing a theoretical basis strategies alleviate mammals future studies.

Language: Английский

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Intestinal barrier damage, systemic inflammatory response syndrome, and acute lung injury: A troublesome trio for acute pancreatitis

Biomedicine & Pharmacotherapy, Journal Year: 2020, Volume and Issue: 132, P. 110770 - 110770

Published: Oct. 2, 2020

Severe acute pancreatitis (SAP), a serious inflammatory disease of the pancreas, can easily lead to systemic response syndrome (SIRS) and multiple organ dysfunction syndromes (MODS). Acute lung injury (ALI) is one most complications SAP. However, specific pathogenesis SAP-associated ALI not fully understood. Crosstalk multi-mechanisms involving pancreatic necrosis, bacteremia, intestinal barrier failure, activation cascades diffuse alveolar damage main reason for unclear pathological mechanism ALI. According previous research on in our laboratory theories put forward by other scholars, we propose that complex pattern based "pancreas-intestine-inflammation/endotoxin-lung (P-I-I/E-L) pathway". In this review, mainly concentrated details "P-I-I/E-L pathway" potential treatments or preventive measures

Language: Английский

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Probiotics fortify intestinal barrier function: a systematic review and meta-analysis of randomized trials

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: April 24, 2023

Background Probiotics play a vital role in treating immune and inflammatory diseases by improving intestinal barrier function; however, comprehensive evaluation is missing. The present study aimed to explore the impact of probiotics on related function, inflammation, microbiota composition. A systematic review meta-analyses were conducted. Methods Four major databases (PubMed, Science Citation Index Expanded, CENTRAL, Embase) thoroughly searched. Weighted mean differences calculated for continuous outcomes with corresponding 95% confidence intervals (CIs), heterogeneity among studies was evaluated utilizing I2 statistic (Chi-Square test), data pooled using random effects meta-analyses. Results Meta-analysis from total 26 RCTs (n = 1891) indicated that significantly improved gut function measured levels TER (MD, 5.27, CI, 3.82 6.72, P < 0.00001), serum zonulin (SMD, -1.58, -2.49 -0.66, 0.0007), endotoxin -3.20, -5.41 -0.98, 0.005), LPS -0.47, -0.85 -0.09, 0.02). Furthermore, probiotic groups demonstrated better efficacy over control reducing factors, including CRP, TNF-α, IL-6. can also modulate structure boosting enrichment Bifidobacterium Lactobacillus. Conclusion work revealed could improve alleviate inflammation microbial dysbiosis. Further high-quality are warranted achieve more definitive conclusion. Clinical trial registration https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=281822 , identifier CRD42021281822.

Language: Английский

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An Overview on Mushroom Polysaccharides: Health-promoting Properties, Prebiotic and Gut Microbiota Modulation Effects and Structure-function Correlation

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 333, P. 121978 - 121978

Published: Feb. 24, 2024

Mushroom polysaccharides are recognized as "biological response modifiers". Besides several bioactivities, a growing interest in their prebiotic potential has been raised due to the gut microbiota modulation potential. This review comprehensively summarizes mushroom polysaccharides' biological properties, structure-function relationship, and underlying mechanisms. It provides recent overview of key findings field (2018–2024). Key limitations on correlation discussed. Although most studies focus β-glucans or extracts, α-glucans chitin have gained interest. Prebiotic capacity associated with chitin, while antimicrobial wound healing is attributed chitin. However, further research utmost importance. Human fecal fermentation reported approach assess potential, indicating impacts intestinal biological, mechanical, chemical immunological barriers. Gut dysbiosis directly connected intestinal, cardiovascular, metabolic, neurological diseases. Concerning modulation, animal experiments suggested proinflammatory cytokines reduction redox balance re-establishment. Most literature focused anticancer immunomodulatory anti-inflammatory, antimicrobial, antiviral, antidiabetic, hypocholesterolemic, antilipidemic, antioxidant, neuroprotective properties A significant gaps directions synergistic effects, mechanisms, correlation, clinical trials scientific data also given.

Language: Английский

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The Importance of Microbiota and Fecal Microbiota Transplantation in Pancreatic Disorders

Diagnostics, Journal Year: 2024, Volume and Issue: 14(9), P. 861 - 861

Published: April 23, 2024

The role of the intestinal microbiota in diagnosis and treatment pancreatic diseases is increasingly significant. Consequently, fecal transplantation (FMT) emerging as a promising therapeutic avenue for various disorders, including cancer, pancreatitis, type 1 diabetes (T1D). This innovative procedure entails transferring gut from healthy donors to individuals affected by ailments with potential restore balance alleviate associated symptoms. FMT represents pioneering approach improve patient outcomes diseases, offering tailored treatments customized individual microbiomes specific conditions. Recent research highlights benefits targeting personalized interventions disorders. However, comprehensive understanding intricate interplay between physiology warrants further investigation. necessity additional studies endeavors remains crucial, especially elucidating both adult pediatric cases pathological

Language: Английский

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Ginsenoside Rb1 ameliorates heart failure through DUSP-1-TMBIM-6-mediated mitochondrial quality control and gut flora interactions

Phytomedicine, Journal Year: 2024, Volume and Issue: 132, P. 155880 - 155880

Published: July 20, 2024

Language: Английский

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The role of short-chain fatty acid in metabolic syndrome and its complications: focusing on immunity and inflammation

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 7, 2025

Metabolic syndrome (Mets) is an important contributor to morbidity and mortality in cardiovascular, liver, neurological, reproductive diseases. Short-chain fatty acid (SCFA), organismal energy donor, has recently been demonstrated increasing number of studies be molecule ameliorating immuno-inflammation, causative factor Mets, improve lipid distribution, blood glucose, body weight levels animal models Mets. This study reviews recent research advances on SCFA Mets from immune-inflammatory perspective, including complications dominated by chronic inflammation, as well the fact that these findings also contribute understanding specific mechanisms which gut flora metabolites metabolic processes humans. review proposes emerging role for inflammatory followed identification major ambiguities further understand anti-inflammatory potential this substance In addition, novel strategies modulate treatment may help mitigate prognosis its complications.

Language: Английский

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Advanced insights into mushroom polysaccharides: Extraction methods, structure-activity, prebiotic properties, and health-promoting effects

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142319 - 142319

Published: March 1, 2025

Language: Английский

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Gut-Lung Crosstalk in Sepsis-Induced Acute Lung Injury

Frontiers in Microbiology, Journal Year: 2021, Volume and Issue: 12

Published: Dec. 23, 2021

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common severe cases of the system with complicated pathogenesis high mortality. Sepsis is leading indirect cause ALI/ARDS in intensive care unit (ICU). The septic complex multifactorial. In development sepsis, disruption intestinal barrier function, alteration gut microbiota, translocation microbiome can lead to systemic local inflammatory responses, which further alter immune homeostasis environment. Disruption may promote propagate ALI/ARDS. turn, when ALI occurs, elevated levels cytokines shift dysregulation mucosal barrier. Thus, interaction between initiate potentiate sepsis-induced gut-lung crosstalk be a promising potential target for intervention. This article reviews underlying mechanism

Language: Английский

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A narrative review of acute pancreatitis and its diagnosis, pathogenetic mechanism, and management

Annals of Translational Medicine, Journal Year: 2021, Volume and Issue: 9(1), P. 69 - 69

Published: Jan. 1, 2021

Acute pancreatitis (AP) is an inflammatory disease that can progress to severe acute (SAP), which increases the risk of death. AP characterized by inappropriate activation trypsinogen, infiltration cells, and destruction secretory cells. Other contributing factors may include calcium (Ca2+) overload, mitochondrial dysfunction, impaired autophagy, endoplasmic reticulum (ER) stress. In addition, exosomes are also associated with pathophysiological processes many human diseases play a biological role in AP. However, pathogenic mechanism has not been fully elucidated needs be further explored inform treatment. Recently, treatment guidelines have changed; minimally invasive therapy advocated more as core multidisciplinary participation "step-up" approach. The surgical procedures gradually changed from open surgery primarily includes percutaneous catheter drainage (PCD), endoscopy, small incision surgery, video-assisted surgery. current for management updated revised aspects. type fluid used, timing, volume, speed administration resuscitation controversial. timing nutritional support prophylactic antibiotic therapy, well or endoscopic intervention, complications still uncertainties could negatively impact prognosis patients' quality life. Consequently, clinicians about optimal treatment, we aimed review recent advances understanding pathogenesis its diagnosis management.

Language: Английский

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