Microplastic and nanoplastic exposure and risk of diabetes mellitus DOI
Hui‐Yi Hsiao,

Chung‐Yi Nien,

Ruei-Feng Shiu

et al.

World Journal of Clinical Cases, Journal Year: 2024, Volume and Issue: 13(3)

Published: Nov. 8, 2024

The issue of plastic pollutants has become a growing concern. Both microplastics (MPs) (particle size < 5 mm) and nanoplastics (NPs) 1 µm) can cause DNA damage, cytotoxicity, oxidative stress in various organisms. primary known impacts microplastic/nanoplastic are observed the liver respiratory system, leading to hepatotoxicity chronic obstructive pulmonary disease. Although research on effects MPs NPs diabetes is still its early stages, there potential concerns. This editorial highlights risk diabetics from co-exposure contaminants MPs/NPs, supported by evidence animal studies chemical compositions MPs/NPs.

Language: Английский

Microplastics and microbiota: Unraveling the hidden environmental challenge DOI Creative Commons
Jean Demarquoy

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(16), P. 2191 - 2194

Published: April 26, 2024

This editorial explores the intricate relationship between microplastics (MPs) and gut microbiota, emphasizing complexity environmental health implications. The a crucial component of gastrointestinal health, is examined in context potential microbial degradation MPs. Furthermore, dysbiosis induced by MPs emerges as consensus, disrupting balance microbiota decreasing diversity. mechanisms triggering dysbiosis, including physical interactions chemical composition, are under investigation. Ongoing research addresses consequences on immune fun-ction, nutrient metabolism, overall host health. bidirectional has significant implications for human Despite uncertainties, negatively impact Further essential to unravel complex assess long-term both well-being.

Language: Английский

Citations

7
Exposure to Polystyrene Microplastic Differentially Affects the Colon and Liver in Adult Male Mice DOI Open Access
Somaye Zangene, Hassan Morovvati, Hojat Anbara

et al.

Environmental Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

ABSTRACT Microplastics (MPs) have emerged as novel environmental pollutant. Their ubiquity in natural environments and the global dissemination of plastic particles through food drink led to oral ingestion these by all kinds living organism. In this investigation, male mice were subjected exposure 2 μm virgin PS‐MPs for 6 weeks. To accomplish this, 36 adult NMRI gavaged with at concentrations 0.01, 0.1, 1 mg/kg body weight. A control group was also accounted for, which received 0.1 mL distilled water. The results show that activity antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase) decreased, while level malondialdehyde increased colon liver. Additionally, findings showed can disrupt integrity intestinal barrier inhibit secretion mucus mice, mucin secretion, cause changes tissue structure Further information regarding toxicity MPs a terrestrial organism obtained study, assist evaluation potential health hazards may pose organisms.

Language: Английский

Citations

0
Climate Change Exacerbates Microplastic Pollution: Environmental Behavior and Human Health Risks DOI
Yang Zheng, Marı́a Dolores Hernando, ‪Damià Barceló

et al.

Current Opinion in Environmental Science & Health, Journal Year: 2025, Volume and Issue: unknown, P. 100608 - 100608

Published: Feb. 1, 2025

Language: Английский

Citations

0
Metabolic Dysfunction-Associated Steatotic Liver Disease Induced by Microplastics: An Endpoint in the Liver–Eye Axis DOI Open Access
Ivan Šoša,

Loredana Labinac,

Manuela Perković

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2837 - 2837

Published: March 21, 2025

There is a significant, rather than just anecdotal, connection between the liver and eyes. This evident in noticeable cases such as jaundice, where sclera has yellow tint. But this can be seen through even more subtle indicators, molecules known hepatokines. relationship not merely anecdotal; some studies, it referred to “liver–eye axis”. Ubiquitous environmental contaminants, microplastics (MPs), enter bloodstream human body conjunctival sac, nasolacrimal duct, upper respiratory tract mucosa. Once absorbed, these substances accumulate various organs cause harm. Toxic from surface of eye lead local oxidative damage by inducing apoptosis corneal cells, irregularly shaped microparticles exacerbate effect. Even other toxicants ocular may absorbed into distributed throughout body. Environmental toxicology presents challenge because many pollutants same route that used certain medications. Previous research indicated accumulation MPs play major role development chronic disease humans. It crucial investigate whether buildup potential fibrosis, or simply consequence conditions cirrhosis portal hypertension.

Language: Английский

Citations

0
Health effects of microplastics and nanoplastics: review of published case reports DOI Creative Commons
Oche Joseph Otorkpa, Chinenye Oche Otorkpa

Environmental Analysis Health and Toxicology, Journal Year: 2024, Volume and Issue: 39(2), P. e2024020 - e2024020

Published: June 21, 2024

Microplastics and nanoplastics (MNPs) represent a pervasive environmental pollutant, raising significant concerns about potential health effects on humans. These tiny plastic particles have been detected across various matrices, including air, water, soil, food sources. While the adverse impacts of MNPs wildlife ecosystems are well-documented, understanding their human is still in its infancy. This study aims to comprehensively review existing case reports documenting outcomes associated with exposure. Through an extensive literature search, relevant articles were identified analyzed. exposure primarily occurs through ingestion inhalation routes. Health digestive system include oxidative stress, inflammation, dysbiosis, metabolic disorders, cases linking gastrointestinal injury liver dysfunction. Respiratory asthma exacerbation hypersensitivity pneumonitis, particularly industries involving production. has also nervous conditions, reproductive toxicity, skeletal interference, excretory disruption, cardiovascular morbidity mortality. Despite limited reports, widespread presence warrants further investigation into risks. underscores urgency mitigating posed by Further research imperative order assess address dangers contamination environment.

Language: Английский

Citations

3
High-Efficiency Degradation of PET Plastics by Glutathione S-Transferase under Mild Conditions DOI

Xiu Huang,

Yong Li, Zhao Shu

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: July 16, 2024

Plastic pollution is a significant environmental concern globally. Plastics are normally considered chemically inert and resistant to biodegradation. Although many papers have reported enzyme-induced biodegradation of plastics, these studies primarily limited enzymes microbial origin or engineered enzymes. This study reveals that poly(ethylene terephthalate) (PET, ∼6000 Da 100 kDa) particles plastic bottle debris (PBD, 24.9 can be efficiently degraded by mammal-origin natural phase II metabolic isozyme, glutathione S-transferase (GST), under mild conditions. The degradation efficiency PET plastics reached 98.9%, with rate 2.6 g·L–1·h–1 ambient physiological conditions at 1 atm. GST varying biological factors (i.e., temperature, light irradiation, pH, presence humic acid protein). We suggest novel mechanism for other than hydrolysis, i.e., the cleavage release monomers via nitridation oxidation. finding also function GST, previously thought only degrade small molecules (<1000 Da). method has been successfully applied in real human serum samples. Additionally, we tested confirmed ability digestive enzyme (trypsin) human-derived (CYP450). Overall, our findings provide potential new route control contribute understanding metabolism fate organisms.

Language: Английский

Citations

3
Microplastic and nanoplastic exposure and risk of diabetes mellitus DOI
Hui‐Yi Hsiao,

Chung‐Yi Nien,

Ruei-Feng Shiu

et al.

World Journal of Clinical Cases, Journal Year: 2024, Volume and Issue: 13(3)

Published: Nov. 8, 2024

The issue of plastic pollutants has become a growing concern. Both microplastics (MPs) (particle size < 5 mm) and nanoplastics (NPs) 1 µm) can cause DNA damage, cytotoxicity, oxidative stress in various organisms. primary known impacts microplastic/nanoplastic are observed the liver respiratory system, leading to hepatotoxicity chronic obstructive pulmonary disease. Although research on effects MPs NPs diabetes is still its early stages, there potential concerns. This editorial highlights risk diabetics from co-exposure contaminants MPs/NPs, supported by evidence animal studies chemical compositions MPs/NPs.

Language: Английский

Citations

0