Alzheimer’s disease: a review on the current trends of the effective diagnosis and therapeutics

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Aug. 9, 2024

The most prevalent cause of dementia is Alzheimer's disease. Cognitive decline and accelerating memory loss characterize it. disease advances sequentially, starting with preclinical stages, followed by mild cognitive and/or behavioral impairment, ultimately leading to dementia. In recent years, healthcare providers have been advised make an earlier diagnosis Alzheimer's, prior individuals developing Regrettably, the identification early-stage in clinical settings can be arduous due tendency patients disregard symptoms as typical signs aging. Therefore, accurate prompt essential order facilitate development disease-modifying secondary preventive therapies onset symptoms. There has a notable shift goal process, transitioning from merely confirming presence symptomatic AD recognizing illness its early, asymptomatic phases. Understanding evolution putting effective diagnostic therapeutic management into practice requires understanding this concept. outcomes study will enhance in-depth knowledge current status disease's treatment, justifying necessity for quest potential novel biomarkers that contribute determining stage disease, particularly earliest stages. Interestingly, latest trial on pharmacological agents, nonpharmacological treatments such behavior modification, exercise, training well alternative approach phytochemicals neuroprotective agents covered detailed.

Language: Английский

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Mind body exercise improves cognitive function more than aerobic- and resistance exercise in healthy adults aged 55 years and older – an umbrella review

European Review of Aging and Physical Activity, Journal Year: 2023, Volume and Issue: 20(1)

Published: Aug. 9, 2023

Exercise is often cited as a major factor contributing to improved cognitive functioning. As result, the relationship between exercise and cognition has received much attention in scholarly literature. Systematic reviews meta-analyses present varying sometimes conflicting results about extent which can influence cognition. The aim of this umbrella review was summarize effects physical on functions (global cognition, executive function, memory, attention, or processing speed) healthy adults ≥ 55 years age.Methods An systematic with investigating effect performed. Databases (CINAHL, Cochrane Library, MEDLINE, PsycInfo, Scopus, Web Science) were searched from inception until June 2023 for randomized non-randomised controlled trials. Full-text articles meeting inclusion criteria reviewed methodological quality assessed. Overlap within included assessed using corrected covered area method (CCA). A random model used calculate overall pooled size sub-analyses specific domains, type timing exercise.Results Database searches identified 9227 reviews. total 20 met criteria. They based 332 original primary studies. Overall considered moderate most 8 more 16 AMSTAR 2 categories. indicated that general small positive (d = 0.22; SE 0.04; p < 0.01). Mind-body had greatest 0.48; 0.06; 0.001). global 0.43; 0,11; 0,001) speed. Chronic effective than acute exercise. Variation across studies due heterogeneity very high.Conclusions function people aged older. To promote aging, mind-body should be over prolonged period complement other types Results inform development guidelines aging.Trial registration PROSPERO (CDR 42022312955).

Language: Английский

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A mechanistic understanding of cognitive performance deficits concurrent with vigorous intensity exercise

Brain and Cognition, Journal Year: 2024, Volume and Issue: 180, P. 106208 - 106208

Published: Aug. 7, 2024

Language: Английский

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Effects of Acute Aerobic Exercise on Emotional Memory Formation in Individuals with Methamphetamine Use Disorder: Encoding vs Consolidation

Psychology of sport and exercise, Journal Year: 2025, Volume and Issue: unknown, P. 102842 - 102842

Published: March 1, 2025

Language: Английский

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The effects of acute exercise on memory: considerations for exercise duration and participant body mass index

Psychological Research, Journal Year: 2025, Volume and Issue: 89(3)

Published: April 19, 2025

Abstract Acute moderate-intensity exercise has been demonstrated to improve memory performance. It is less clear, however, whether the duration of acute and body mass index (BMI) may moderate this effect. Thus, purpose experiment was evaluate effects differing durations (20- 40-minutes) on immediate long-term performance, while considering BMI as a moderating factor in performance relationship. Twenty-three young healthy adults participated within-subjects experiment. Participants completed four different experimental visits including either exercising at intensity (or standing treadmill) for 20- or 40-minutes, followed by an free-recall assessment then delayed 24-hr recall. improved regardless exercise. Further, greater individuals with higher when they engaged shorter (20 min) compared longer (40

Language: Английский

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The Acute Effects of Aerobic Exercise on Cognitive Functions ın Young Adults

Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi, Journal Year: 2025, Volume and Issue: 16(1), P. 38 - 44

Published: April 24, 2025

Objective: The acute effects of aerobic exercise on cognitive function in young adults are well-established, yet the remain incompletely understood. We aimed to investigate 1-session functions healthy adults. This study involved 52 (24 males and 28 females) studying xxx Faculty between xxx. Material Method: routine consisted a 5-minute warm-up, followed by 20-minute period increased intensity, concluded with cool-down. employed Stroop Test evaluate participants' attention levels. In addition, number sequence (SD) subtest Wechsler Memory Scale-Generalized Form (WMS-G) was used assess memory level pre- post-exercise. Results: mean age participants 23.34±1.13 years. participant showed significant improvement stroop test times but not for correct errors (Stroop 1, 2, 3, 4, 5= p< 0.0001, 0.008, 0.001, respectively). no WMS-G values (WMS-G normal reverse= p>0.308 p >0.329). Conclusion: Aerobic has been found potentially have beneficial abilities adults, even after single session. Clinicians field rehabilitation may enhance treatment outcomes incorporating activities into programmes. Further studies large sample groups different types exercises (swimming, running, etc.) important more clearly demonstrate functions.

Language: Английский

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Exercising4Cognition: Can Short Bouts of Aerobic Exercise Improve Cognitive Performance in Healthy Adults for Primary Health Prevention? Previous Findings and Suggestions for the Future

Healthcare, Journal Year: 2025, Volume and Issue: 13(4), P. 368 - 368

Published: Feb. 10, 2025

Background: Regular physical activity (PA) and regular exercise (RE) are essential for an active healthy lifestyle. Additionally, the short-term effects have been investigated to understand how acute bout of impacts cognitive processing, important aspect mental health well-being. Previous studies confirmed positive effects. However, several factors human can influence this relationship. Aim/Methods/Results: This perspective paper has three main objectives: firstly, discussing that exercise-cognition significantly across according previous reviews meta-analytic could be explained theoretically; secondly, highlighting knowledge gaps research questions future research; thirdly, what conclusion drawn promotion. A particular focus is given bouts aerobic adults as target group primary prevention. Conclusions: The summary findings shows on performance in depend (a) such duration intensity exercise, (b) type task domain functions, (c) individual individuals. Still, open concern ideal duration, timing exercise. In particular, more needed determine whether exercises short above especially below moderate improve functions adults. Methodologically, these should addressed by multimethod designs consider intra- interindividual comparisons different response levels (self-report, behavioral, psychophysiological). conclusion, answering pave way recommendations healthcare professionals prescribe brief a booster young To end, concepts extended arousal neurovisceral integration useful framework models include factors, like self-regulatory abilities interactions motivation during, pre-to-post testing sessions.

Language: Английский

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Exercise Intensity improves performance on a Spatial Memory Task

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Previous research suggests exercise improves spatial navigation abilities, though the effects of different intensities on this cognitive function have not been explored. The current study assessed influence moderate-intensity and high-intensity acute learning memory, focusing acquisition survey route knowledge in young adults. Thirty-two participants (22.6 ± 1.7 y) were randomly assigned to one three groups: 1) no-exercise control (n = 10); 2) continuous training (MICT; 30 min at 65% maximal oxygen consumption) 12); 3) sprint interval (SIT; 4x30 sec all-out interspersed with 4 recovery) 10). Spatial abilities using a virtual reality (VR) maze evaluations time points: pre-exercise (TP1), immediately post-exercise (TP2), 48 h (TP3). Angular error (AE) was primary measure accuracy. Both MICT SIT groups exhibited improvements memory indicated by reductions AE from TP1 TP3 (p < .001) group showed greater reduction compared .039), suggesting more pronounced benefit higher-intensity exercise. group, however, no significant change .869), indicating improvement without intervention. findings suggest that exercise, particularly higher intensities, enhances alongside learning. It is possible can be used as intervention enhance functions, navigation.

Language: Английский

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The positive impact of physical activity on academic performance among catalan adolescents

Cogent Education, Journal Year: 2025, Volume and Issue: 12(1)

Published: April 27, 2025

Language: Английский

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Implications of Physical Exercise on Episodic Memory and Anxiety: The Role of the Serotonergic System

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(14), P. 11372 - 11372

Published: July 12, 2023

There is a growing interest in investigating the effects of physical exercise on cognitive performance, particularly episodic memory. Similarly, an increasing number studies recent decades have studied activity mood and anxiety disorders. Moreover, COVID-19 pandemic has raised awareness importance regular for both mental health. Nevertheless, exact mechanisms underlying these are not fully understood. Interestingly, findings suggest that serotonergic system may play key role mediating memory anxiety. In this review, we discuss impact human animal models. addition, explore accumulating evidence supports

Language: Английский

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